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Roles of angiopoietin-like proteins in regulation of stem cell activity

Kadomatsu, Tsuyoshi, Oike, Yuichi·2019·The Journal of Biochemistry
DOI 10.1093/jb/mvz005
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Abstract

Various types of stem cells reside in the body and self-renew throughout an organism’s lifetime. Such self-renewal is essential for maintenance of tissue homeostasis and is co-ordinately regulated by stem cell-intrinsic signals and signals from stem cell niche. Angiopoietin is a niche-derived signalling molecule well known to contribute to maintenance of haematopoietic stem cells (HSCs). Angiopoietin-like proteins (ANGPTLs) are structurally similar to angiopoietin, and recent studies reveal that they function in angiogenesis, lipid and energy metabolism and regulation of inflammation. However, unlike angiopoietins, activities of ANGPTLs in stem cell maintenance have remained unclear. Recently, several studies have reported an association of ANGPTL signalling with stem cell maintenance. Here, we summarize those findings with a focus on HSCs, intestinal stem cells, neural stem cells and cancer stem cells and discuss mechanisms underlying ANGPTL-mediated stem cell maintenance.

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Metadata

Authors
Kadomatsu, T., & Oike, Y.
Affiliations
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan
Venue
The Journal of Biochemistry
Publisher
Oxford University Press (OUP)
Published
2019-01-23
Volume
165
Issue
4
Pages
309-315
ISSN
  • 0021-924X
  • 1756-2651
DOI
10.1093/jb/mvz005
Cited by
23
References
2
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • MEXT (17H05652, 18K07236)
  • Core Research for Evolutional Science and Technology
  • CREST
  • Japan Science and Technology Agency (13417915)
  • CREST program of the Japan Agency (JP18gm0610007)

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CoChat. (2026). Citation check: Roles of angiopoietin-like proteins in regulation of stem cell activity. https://app.cochat.ai/papers/10.1093/jb/mvz005
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Kadomatsu, T., & Oike, Y. (2019). Roles of angiopoietin-like proteins in regulation of stem cell activity. The Journal of Biochemistry. https://doi.org/10.1093/jb/mvz005