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The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Angiopoietin-related growth factor antagonizes obesity and insulin resistance

Oike, Yuichi, Akao, Masaki, Yasunaga, Kunio, Yamauchi, Toshimasa, Morisada, Tohru, Ito, Yasuhiro, Urano, Takashi, Kimura, Yoshishige, Kubota, Yoshiaki, Maekawa, Hiromitsu, Miyamoto, Takeshi, Miyata, Keishi, Matsumoto, Shun-ichiro, Sakai, Juro, Nakagata, Naomi, Takeya, Motohiro, Koseki, Haruhiko, Ogawa, Yoshihiro, Kadowaki, Takashi, Suda, Toshio·2005·Nature Medicine
DOI 10.1038/nm1214
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Abstract

Angiopoietin-related growth factor (AGF), a member of the angiopoietin-like protein (Angptl) family, is secreted predominantly from the liver into the systemic circulation. Here, we show that most (>80%) of the AGF-deficient mice die at about embryonic day 13, whereas the surviving AGF-deficient mice develop marked obesity, lipid accumulation in skeletal muscle and liver, and insulin resistance accompanied by reduced energy expenditure relative to controls. In parallel, mice with targeted activation of AGF show leanness and increased insulin sensitivity resulting from increased energy expenditure. They are also protected from high-fat diet-induced obesity, insulin resistance and nonadipose tissue steatosis. Hepatic overexpression of AGF by adenoviral transduction, which leads to an approximately 2.5-fold increase in serum AGF concentrations, results in a significant (P < 0.01) body weight loss and increases insulin sensitivity in mice fed a high-fat diet. This study establishes AGF as a new hepatocyte-derived circulating factor that counteracts obesity and related insulin resistance.

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Crossref · 10.1038/nm1214

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10 of 10 references verified0 citation errors · 0 not checkable

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  • ANGPTL6 does not appear to modulate plasma TG levels.

    “However, despite these marked changes, ANGPTL6 does not appear to modulate plasma TG levels (40, 41).”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [41]

  • Mice deficient in ANGPTL6 become obese, insulin resistant, and accumulate lipid in skeletal muscle and liver.

    “Mice deficient in ANGPTL6 (also known as angiopoietin-related growth factor) become obese, insulin resistant, and accumulate lipid in skeletal muscle and liver (41).”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [41]

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Research works printed but not linked: 31

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Metadata

Authors
Oike, Y., Akao, M., Yasunaga, K., Yamauchi, T., Morisada, T., Ito, Y., Urano, T., Kimura, Y., Kubota, Y., Maekawa, H., Miyamoto, T., Miyata, K., Matsumoto, S.-I., Sakai, J., Nakagata, N., Takeya, M., Koseki, H., Ogawa, Y., Kadowaki, T., & Suda, T.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2005-03-20
Volume
11
Issue
4
Pages
400-408
ISSN
  • 1078-8956
  • 1546-170X
DOI
10.1038/nm1214
Cited by
200
References
10
Language
en
Licence
www.springer.com/tdm (tdm)

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