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Genomic instability and cancer: an introduction
Open accessAbstract
Genomic instability refers to an increased tendency of alterations in the genome during the life cycle of cells. It is a major driving force for tumorigenesis. During a cell division, genomic instability is minimized by four major mechanisms: high-fidelity DNA replication in S-phase, precise chromosome segregation in mitosis, error free repair of sporadic DNA damage, and a coordinated cell cycle progression. This introduction summarizes the major molecular processes that contribute to these mechanisms in the context of prevention of genomic instability and tumorigenesis.
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“Additionally, due to the instability of the genome of cancer cells, they have evolved many mechanisms to escape CRISPR/Cas9-mediated genome editing, such as mutation of the PAM sequence and the recognition site etc. [120–122].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [121]
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Metadata
- Authors
- Shen, Z.
- Affiliations
- Rutgers Cancer Institute (US)
- Corresponding author
- Shen, Z.
- ORCID
- Shen, Z.
- Venue
- Journal of Molecular Cell Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-30
- Volume
- 3
- Issue
- 1
- Pages
- 1-3
- ISSN
- 1674-2788 (ISSN-L)
- OpenAlex
- W2043251251
- Cited by
- 229
- References
- 0
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 12 · 2022: 26 · 2021: 18 · 2020: 21 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 23 · 2015: 12 · 2014: 7 · 2013: 16 · 2012: 10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Cancer Institute (R01CA156706)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- genomic instability, carcinogenesis, DNA replication fidelity, chromosome segregation, DNA repair, cell cycle regulation, cancer prevention
- MeSH terms
- Animals, Cell Division, DNA Replication, Humans, Mitosis, Neoplasms, S Phase, Chromosome Segregation, Genomic Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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