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Genomic instability and cancer: an introduction
Open accessAbstract
Genomic instability refers to an increased tendency of alterations in the genome during the life cycle of cells. It is a major driving force for tumorigenesis. During a cell division, genomic instability is minimized by four major mechanisms: high-fidelity DNA replication in S-phase, precise chromosome segregation in mitosis, error free repair of sporadic DNA damage, and a coordinated cell cycle progression. This introduction summarizes the major molecular processes that contribute to these mechanisms in the context of prevention of genomic instability and tumorigenesis.
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“Additionally, due to the instability of the genome of cancer cells, they have evolved many mechanisms to escape CRISPR/Cas9-mediated genome editing, such as mutation of the PAM sequence and the recognition site etc. [120–122].”
From Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities (2018) · cites this paper as [121]
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“…maintain their genome stability by an error-free replication of genetic material, the repair of replication mistakes or damaged genetic material, precise separation of genetic material during the formation of chromosomes, and precise chromosomal arrangement during meiosis and mitosis [57–59].”
Müllner, E. (2013) · University of Vienna · doi:10.25365/thesis.27936
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Milic, M., Ademović, N., Manojlović-Gačić, E., et al. (2026) · Life · doi:10.3390/life16030374
Amine, R. E. (2017) · theses.fr (ABES) · doi:10.70675/79702f70za566z4f62z8665zfa738acf7b3f
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“25–27 These alterations render tumor cells highly dependent on specific survival pathways, making them particularly sensitive to corresponding SL targets.”
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Fong, I. L. (2012) · Unimas Institutional Repository (Universiti Malaysia Sarawak)
Metadata
- Authors
- Shen, Z.
- Affiliations
- Rutgers Cancer Institute (US)
- Corresponding author
- Shen, Z.
- ORCID
- Shen, Z.
- Venue
- Journal of Molecular Cell Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-30
- Volume
- 3
- Issue
- 1
- Pages
- 1-3
- ISSN
- 1674-2788 (ISSN-L)
- OpenAlex
- W2043251251
- Cited by
- 229
- References
- 0
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 12 · 2022: 26 · 2021: 18 · 2020: 21 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 23 · 2015: 12 · 2014: 7 · 2013: 16 · 2012: 10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Cancer Institute (R01CA156706)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- genomic instability, carcinogenesis, DNA replication fidelity, chromosome segregation, DNA repair, cell cycle regulation, cancer prevention
- MeSH terms
- Animals, Cell Division, DNA Replication, Humans, Mitosis, Neoplasms, S Phase, Chromosome Segregation, Genomic Instability
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