The DOI matches its Crossref record; 50 of the 52 references it cites were found in a registry or an index.
Metabolic Evidence for Adaptation to a High Protein Diet in Rats
Open accessAbstract
This study was designed to assess the effects of long-term adaptation to a high protein diet on energy intake, body weight gain, body composition and splanchnic metabolic indicators in rats. For this purpose, adult male Wistar rats were fed either a 50 g/100 g dry matter (DM) protein diet (P50 group) or a 14 g/100 g DM protein diet (P14 group) for 21 d. These two groups were compared with a P14 pair-fed (P14-pf) group that consumed the same daily energy as the P50 group. The energy intake of the P50 group was 16 +/- 1% less than that of the P14 group (P < 0.05), and the P50 group had significantly lower body weight. The P50 group had significantly less adipose tissue compared with both P14 and P14-pf rats. The activities of the brush border membrane enzymes, neutral aminopeptidase and gamma-glutamyl transferase, were significantly higher in the P50 group than in the P14 rats. Similarly, the activities of alanine aminotransferase, arginase and serine dehydratase were significantly higher in the liver of P50 rats compared with P14 rats. Both amino acid transporter system A and X(A,G-) activities, measured in freshly isolated hepatocytes, were significantly higher in the P50 group (8- and 1.5-fold, P < 0.05, respectively) compared with the P14 group. The 1.5-fold increase in the steady-state activity of X(A,G-) was accompanied by a doubling of EAAT2 mRNA, involved in the system X(A,G-). This study provides confirmation that specific biochemical and molecular adaptive processes of the splanchnic area are involved in the response to variations in the protein content of the diet.
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“some studies suggest that rats will consume and grow rather well on high-protein diets if given sufficient time to adapt to the diet”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [66]
In the citing paper
“As expected (42), control animals fed a high-protein diet (Fig. 5C, D) exhibited decreased body weight gain, food intake, and other body composition parameters compared with control animals fed normal diet (Fig. 5A, B).”
From Anabolic effect of plant brassinosteroid (2011) · cites this paper as [42]
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High protein intake sustains weight maintenance after body weight loss in humans
Westerterp-Plantenga, M. S., Lejeune, M. P. G. M., Nijs, I., van Ooijen, M., & Kovacs, E. M. R. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802461 · Cited by 326
Therapeutic Use of Citrulline in Cardiovascular Disease
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“levels of dietary or circulating L-arginine can increase arginase activity in the liver, kidney, vasculature and probably other tissues, which increases rate of L-arginine catabolism (37,57,80,90).”
BackgroundThe role of the autonomic nervous liver innervation in the control of energy metabolism
Yi, C., la Fleur, S. E., Fliers, E., & Kalsbeek, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.006 · Cited by 240
“A high protein diet is able to inhibit food intake [134,135] but this effect might not be due to a”
BackgroundRopelle, E. R., Pauli, J. R., Fernandes, M. F., Rocco, S. A., Marin, R. M., Morari, J., Souza, K. K., Dias, M. M., Gomes‐Marcondes, M. C. C., Gontijo, J. A. R., et al. (2007) · Diabetes · doi:10.2337/db07-0573 · Cited by 214
“These results are in agreement with others (37,38) and can be explained, to some extent, by the reduction in caloric intake, but we also observed increased UCP-1 levels that may reflect an increase in energy expenditure.”
ResultRetractedAdditional Protein Intake Limits Weight Regain after Weight Loss in Humans
Lejeune, M. P. G. M., Kovacs, E. M. R., & Westerterp-Plantenga, M. S. (2005) · British Journal of Nutrition · doi:10.1079/bjn20041305 · Cited by 211
“The observation that body mass regain consisting only of FFM results in a slower weight regain is in line with our hypothesis that when the composition of the weight regained consists of a greater FFM, the inevitable increase in body mass will be slower.”
BackgroundInfluential
Metadata
- Authors
- Jean, C., Rome, S., Mathé, V., Huneau, J.-F., Aattouri, N., Fromentin, G., Achagiotis, C. L., & Tomé, D.
- Affiliations
- Physiologie de la Nutrition et du Comportement Alimentaire (FR)
- Corresponding author
- Tomé, Daniel
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 131
- Issue
- 1
- Pages
- 91-98
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1918271356
- Cited by
- 189
- References
- 52
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 9 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 13
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- high-protein diet, energy intake, weight gain, body composition, adipose tissue, splanchnic metabolism, brush border enzymes, gamma-glutamyl transferase, amino acid transporters, system A, hepatocytes
- MeSH terms
- Adaptation, Physiological, Animals, Body Composition, Carrier Proteins, Dietary Proteins, Energy Metabolism, Enzymes, Intestines, Liver, Male, Metabolism, Weight Gain, Rats, Wistar, Receptors, Glutamate, Receptors, Neurotransmitter, Amino Acid Transport Systems, Amino Acid Transport System X-AG, Excitatory Amino Acid Transporter 2, Symporters, Glutamate Plasma Membrane Transport Proteins, Rats
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