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Cited by 189Animal Nutrition and PhysiologyDiet, Metabolism, and DiseaseMuscle metabolism and nutrition

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Metabolic Evidence for Adaptation to a High Protein Diet in Rats

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Jean, Clémentine, Rome, Sophie, Mathé, Véronique, Huneau, Jean-François, Aattouri, Najat, Fromentin, Gilles, Achagiotis, Christiane Larue, Tomé, Daniel·2001·The Journal of Nutrition
DOI 10.1093/jn/131.1.91
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Abstract

This study was designed to assess the effects of long-term adaptation to a high protein diet on energy intake, body weight gain, body composition and splanchnic metabolic indicators in rats. For this purpose, adult male Wistar rats were fed either a 50 g/100 g dry matter (DM) protein diet (P50 group) or a 14 g/100 g DM protein diet (P14 group) for 21 d. These two groups were compared with a P14 pair-fed (P14-pf) group that consumed the same daily energy as the P50 group. The energy intake of the P50 group was 16 +/- 1% less than that of the P14 group (P < 0.05), and the P50 group had significantly lower body weight. The P50 group had significantly less adipose tissue compared with both P14 and P14-pf rats. The activities of the brush border membrane enzymes, neutral aminopeptidase and gamma-glutamyl transferase, were significantly higher in the P50 group than in the P14 rats. Similarly, the activities of alanine aminotransferase, arginase and serine dehydratase were significantly higher in the liver of P50 rats compared with P14 rats. Both amino acid transporter system A and X(A,G-) activities, measured in freshly isolated hepatocytes, were significantly higher in the P50 group (8- and 1.5-fold, P < 0.05, respectively) compared with the P14 group. The 1.5-fold increase in the steady-state activity of X(A,G-) was accompanied by a doubling of EAAT2 mRNA, involved in the system X(A,G-). This study provides confirmation that specific biochemical and molecular adaptive processes of the splanchnic area are involved in the response to variations in the protein content of the diet.

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Research works printed but not linked: 3

  1. McCarthy, 1980, Intestinal enzymal adaptation to normal diets of different composition, Am. J. Physiol, 239, G445
  2. Rowe, 1970, Glutamine synthase, Methods Enzymol, 17, 900
  3. Waterlow, J. C. (1985) What do we mean by adaptation? In: Nutritional Adaptation in Man (Blaxter, K. & Waterlow, J. C., eds.), pp. 1–11. John Libbey, London, UK.

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Metadata

Authors
Jean, C., Rome, S., Mathé, V., Huneau, J.-F., Aattouri, N., Fromentin, G., Achagiotis, C. L., & Tomé, D.
Affiliations
Physiologie de la Nutrition et du Comportement Alimentaire (FR)
Corresponding author
Tomé, Daniel
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2001-01
Volume
131
Issue
1
Pages
91-98
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/131.1.91
OpenAlex
W1918271356
Cited by
189
References
52
Citations by year
2026: 1 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 9 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 13
FWCI
13.79
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
high-protein diet, energy intake, weight gain, body composition, adipose tissue, splanchnic metabolism, brush border enzymes, gamma-glutamyl transferase, amino acid transporters, system A, hepatocytes
MeSH terms
Adaptation, Physiological, Animals, Body Composition, Carrier Proteins, Dietary Proteins, Energy Metabolism, Enzymes, Intestines, Liver, Male, Metabolism, Weight Gain, Rats, Wistar, Receptors, Glutamate, Receptors, Neurotransmitter, Amino Acid Transport Systems, Amino Acid Transport System X-AG, Excitatory Amino Acid Transporter 2, Symporters, Glutamate Plasma Membrane Transport Proteins, Rats

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