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Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice
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In the citing paper
“In the same study, 20 μM piperine was found to inhibit the formation of EGCG-3′-glucuronide in human HT-29 colon adenocarcinoma cells by ~50%.”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Lambert et al., 2004
In the citing paper
“in rodents and human HT-29 colon adenocarcinoma cells, piperine has been shown to inhibit glucuronidation of EGCG and 3-OH-benzo(a)pyrene at concentrations as low as 8 μM (Atal et al., 1985; Lambert et al., 2004).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Lambert et al., 2004
In the citing paper
“Piperine also inhibited glucuronidation of (−)-epigallocatechin-3-gallate (EGCG) in mice resulting in increased EGCG bioavailability (Lambert et al., 2004).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Lambert et al., 2004
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Research works printed but not linked: 16
- Lambert, 2003, Mechanisms of cancer prevention by tea constituents, J. Nutr, 133, 3262S, 10.1093/jn/133.10.3262S · DOI · Paper page
- Yang, 2002, Inhibition of carcinogenesis by tea, Annu. Rev. Pharmacol Toxicol, 42, 25, 10.1146/annurev.pharmtox.42.082101.154309 · DOI · Paper page
- Lambert, 2003, Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice, J. Nutr, 133, 10.1093/jn/133.12.4172 · DOI · Paper page
- Chen, 1997, Absorption, distribution, elimination of tea polyphenols in rats, Drug Metab. Dispos, 25, 1045
- Lu, 2003, Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (−)-epigallocatechin gallate, Drug Metab. Dispos, 31, 572, 10.1124/dmd.31.5.572 · DOI · Paper page
- Lu, 2003, Glucuronides of tea catechins: enzymology of biosynthesis and biological activities, Drug Metab. Dispos, 31, 452, 10.1124/dmd.31.4.452 · DOI
- Singh, 1986, Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content, J. Pharmacol. Exp. Ther, 236, 488, 10.1016/S0022-3565(25)38910-X · DOI
- Reen, 1993, Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine, Biochem. Pharmacol, 46, 229, 10.1016/0006-2952(93)90408-O · DOI
- Shoba, 1998, Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers, Planta Med, 64, 353, 10.1055/s-2006-957450 · DOI · Paper page
- Thomas, 1983, Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics, J. Biol. Chem, 258, 4590, 10.1016/S0021-9258(18)32664-4 · DOI
- Hong, 2003, Involvement of multidrug resistance-associated proteins in regulating cellular levels of (−)-epigallocatechin-3-gallate and its methyl metabolites, Biochem. Biophys. Res. Commun, 310, 222, 10.1016/j.bbrc.2003.09.007 · DOI
- Lee, 2000, An improved method for the determination of green and black tea polyphenols in biomatrices by high-performance liquid chromatography with coulometric array detection, Anal. Biochem, 279, 164, 10.1006/abio.2000.4487 · DOI
- Bajad, 2001, Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice, Planta Med, 67, 176, 10.1055/s-2001-11505 · DOI
- Groning, 1998, Acyclovir serum concentrations following peroral administration of magnetic depot tablets and the influence of extracorporal magnets to control gastrointestinal transit, Eur. J. Pharm. Biopharm, 46, 285, 10.1016/S0939-6411(98)00052-6 · DOI
- Callreus, 1999, Changes in gastrointestinal motility influence the absorption of desmopressin, Eur. J. Clin. Pharmacol, 55, 305, 10.1007/s002280050633 · DOI
- Bhardwaj, 2002, Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4, J. Pharmacol. Exp Ther, 302, 645, 10.1124/jpet.102.034728 · DOI · Paper page
Cited by
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Srinivasan, K. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390601062054 · Cited by 821
Smith, A., Giunta, B., Bickford, P. C., Fountain, M., Tan, J., & Shytle, R. D. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.012 · Cited by 280
Bioavailability challenges associated with development of anti-cancer phenolics
Gao, S., & Hu, M. (2010) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955710791384081 · Cited by 242
Volak, L. P., Ghirmai, S., Cashman, J. R., & Court, M. H. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.020552 · Cited by 214
Overview of metabolism and bioavailability enhancement of polyphenols
Lewandowska, U., Szewczyk, K., Hrabec, E., Janecka, A., & Gorlach, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404439b · Cited by 196
Metadata
- Authors
- Lambert, J. D., Hong, J., Kim, D. H., Mishin, V. M., & Yang, C. S.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 134
- Issue
- 8
- Pages
- 1948-1952
- ISSN
- 0022-3166
- Cited by
- 213
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 6766 d)
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- CoChat. (2026). Citation check: Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. https://app.cochat.ai/papers/10.1093/jn/134.8.1948
- The paper
- Lambert, J. D., Hong, J., Kim, D. H., Mishin, V. M., & Yang, C. S. (2004). Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. The Journal of Nutrition. https://doi.org/10.1093/jn/134.8.1948
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
