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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
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Claims other papers make about this one
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In the citing paper
“Pharmacokinetic studies in cancer patients and healthy volunteers have shown that at doses of 8 g per day of pure curcumin (99.3%), 3.6 g of curcuminoids, or piperine (20 mg) co-administered with 2 g of curcumin, the highest mean maximum plasma concentration (Cmax) was 1.77 ± 1.87 μM (Shoba et al., 1998; Cheng et al., 2001; Sharma et al., 2004).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Shoba et al., 1998
In the citing paper
“Piperine, found in the extract of black pepper, enhances the relative oral bioavailability of curcuminoids by as much as 20-fold in healthy human volunteers (Shoba et al., 1998).”
From Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor (2008) · cites this paper as Shoba et al., 1998
In the citing paper
“Additionally, 20 mg of pure piperine increased the serum AUC0–3h of curcumin by 20-fold relative to curcumin taken without piperine [5].”
From Predicting Food–Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling (2024) · cites this paper as [5]
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Percentages, sums and reported differences re-computed from the paper’s own numbers.
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Citations
Cited by
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Curcumin: A Review of Its Effects on Human Health
Hewlings, S., & Kalman, D. (2017) · Foods · doi:10.3390/foods6100092 · Cited by 2,720
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260
Aggarwal, B. B., & Sung, B. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.002 · Cited by 1,140
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Srinivasan, K. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390601062054 · Cited by 821
Metadata
- Authors
- Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1998-05
- Volume
- 64
- Issue
- 04
- Pages
- 353-356
- ISSN
- 0032-0943
- 1439-0221
- Cited by
- 1,656
- References
- 0
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. https://app.cochat.ai/papers/10.1055/s-2006-957450
- The paper
- Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. (1998). Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Medica. https://doi.org/10.1055/s-2006-957450
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
