Cited by 69Antifungal resistance and susceptibilityGut microbiota and healthProbiotics and Fermented Foods

Gastric colonization of Candida albicans differs in mice fed commercial and purified diets.

Open access
Yamaguchi, Natsu, Sonoyama, Kei, Kikuchi, Hiroto, Nagura, Taizo, Aritsuka, Tsutomu, Kawabata, Jun·2005·The Journal of Nutrition

Abstract

It has been difficult to produce persistent colonization by Candida albicans in the gastrointestinal tract of adult mice without the use of antibiotics and immunosuppressants. We hypothesized that diet influences the colonization of C. albicans and tested the hypothesis. BALB/c mice fed either a commercial rodent diet or a nutritionally adequate mixture of purified ingredients were inoculated i.g. with C. albicans (5 x 10(7) cells). Gastrointestinal colonization was examined by fecal culture, tissue culture, and histology. Mice fed the purified diet had a high fecal recovery of C. albicans [5-6log(10) colony forming units (cfu)/g feces] throughout the experimental period (6 wk), and the major site of colonization was the stomach. C. albicans was undetectable in the feces of mice fed the commercial diet 2 wk after inoculation. Immunosuppressants induced systemic dissemination of C. albicans in mice fed the purified diet. The number of lactobacilli and the concentration of organic acids in the stomach were significantly lower in mice fed the purified diet than in those fed the commercial diet. In vitro culture experiments revealed that acetic and lactic acids suppressed the growth of C. albicans. These results suggest that a reduction in lactobacilli in the stomach of mice fed the purified diet contributed to sustained gastric candidiasis. We therefore propose a novel model of sustained gastric candidiasis by a single i.g. inoculation of C. albicans in healthy adult mice fed a purified diet.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/jn/135.1.109

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yamaguchi, N., Sonoyama, K., Kikuchi, H., Nagura, T., Aritsuka, T., & Kawabata, J.
Affiliations
Hokkaido University (JP)
Corresponding author
Sonoyama, Kei
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2005-01
Volume
135
Issue
1
Pages
109-115
ISSN
0022-3166 (ISSN-L)
OpenAlex
W2115414596
Cited by
69
References
38
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
0.64
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
Candida albicans, gastric colonization, gastric candidiasis, diet, purified diet, lactobacilli, organic acids, acetic acid, lactic acid, immunosuppression, systemic candidiasis, mouse model, fecal recovery
MeSH terms
Animals, Animal Feed, Antibodies, Fungal, Candida albicans, Carboxylic Acids, Gastric Mucosa, Gastrointestinal Contents, Male, Mice, Inbred BALB C, Stomach, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review