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Cited by 208Antifungal resistance and susceptibilityGut microbiota and healthProbiotics and Fermented Foods

Ecology of Candida albicans gut colonization: inhibition of Candida adhesion, colonization, and dissemination from the gastrointestinal tract by bacterial antagonism

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Kennedy, M J, Volz, P A·1985·Infection and Immunity
DOI 10.1128/iai.49.3.654-663.1985PMC PMC261235
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Abstract

Antibiotic-treated and untreated Syrian hamsters were inoculated intragastrically with Candida albicans to determine whether C. albicans could opportunistically colonize the gastrointestinal tract and disseminate to visceral organs. Antibiotic treatment decreased the total population levels of the indigenous bacterial flora and predisposed hamsters to gastrointestinal overgrowth and subsequent systemic dissemination by C. albicans in 86% of the animals. Both control hamsters not given antibiotics and antibiotic-treated animals reconventionalized with an indigenous microflora showed significantly lower gut populations of C. albicans, and C. albicans organisms were cultured from the visceral organs of 0 and 10% of the animals, respectively. Conversely, non-antibiotic-treated hamsters inoculated repeatedly with C. albicans had high numbers of C. albicans in the gut, and viable C. albicans was recovered from the visceral organs of 53% of the animals. Examination of the mucosal surfaces from test and control animals indicated further that animals which contained a complex indigenous microflora had significantly lower numbers of C. albicans associated with their gut walls than did antibiotic-treated animals. The ability of C. albicans to associate with intestinal mucosal surfaces also was tested by an in vitro adhesion assay. The results indicate that the indigenous microflora reduced the mucosal association of C. albicans by forming a dense layer of bacteria in the mucus gel, out-competing yeast cells for adhesion sites, and producing inhibitor substances (possibly volatile fatty acids, secondary bile acids, or both) that reduced C. albicans adhesion. It is suggested, therefore, that the indigenous intestinal microflora suppresses C. albicans colonization and dissemination from the gut by inhibiting Candida-mucosal association and reducing C. albicans population levels in the gut.

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  • C. albicans is a member of the healthy microbiota, asymptomatically colonizing the gastrointestinal tract, reproductive tract, oral cavity, and skin of most humans.

    “It is a member of the healthy microbiota, asymptomatically colonizing the gastrointestinal (GI) tract, reproductive tract, oral cavity, and skin of most humans (1, 64, 87, 97, 99).”

    From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [87]

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  1. Green J. R., Bulmer G. S. Gastrointestinal inoculation of Cryptococcus neoformans in mice. Sabouraudia. 1979 Sep;17(3):233–240. [PubMed] [Google Scholar]

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Authors
Kennedy, M. J., & Volz, P. A.
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1985-09
Volume
49
Issue
3
Pages
654-663
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.49.3.654-663.1985
PMC
PMC261235
OpenAlex
W1907372042
Cited by
208
References
65
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 5 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 2
FWCI
7.45
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Infection and Immunity (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
Candida albicans, intestinal colonization, bacterial antagonism, antibiotic-induced dysbiosis, systemic candidiasis, mucosal colonization, secondary bile acids, volatile fatty acids, Syrian hamster model, opportunistic fungal infection
MeSH terms
Adhesiveness, Animals, Antibiosis, Anti-Bacterial Agents, Candida albicans, Cecum, Digestive System, Ecology, Cricetinae, Intestinal Mucosa, Male, Mesocricetus, Microscopy, Electron, Scanning, Bacterial Physiological Phenomena

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