Cited by 288Fatty Acid Research and HealthAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Chronic Administration of Docosahexaenoic Acid Ameliorates the Impairment of Spatial Cognition Learning Ability in Amyloid β–Infused Rats

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Hashimoto, Michio, Tanabe, Yoko, Fujii, Yoshimi, Kikuta, Toshihiko, Shibata, Hitoshi, Shido, Osamu·2005·The Journal of Nutrition

DOI 10.1093/jn/135.3.549

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Abstract

We investigated whether administration of docosahexaenoic acid (DHA), a major (n-3) fatty acid of the brain, ameliorates the impairment of learning ability in an animal model of Alzheimer's disease (AD), rats infused with amyloid-beta (Abeta) peptide (1-40) into the cerebral ventricle. Inbred 3rd generation male rats (20 wk old) fed a fish oil-deficient diet were randomly divided into 4 groups: a vehicle group, an Abeta peptide-infused group (Abeta group), a DHA group, and an Abeta + DHA group. A mini-osmotic pump filled with Abeta peptide or vehicle was implanted in the rats, and they were tested for learning ability-related reference and working memory in an 8-arm radial maze. The rats were then orally fed DHA dissolved in 5% gum Arabic solution at 300 mg/(kg . d) (DHA and Abeta + DHA groups) or vehicle alone (vehicle and Abeta groups) and tested again for learning ability. DHA administered for 12 wk significantly reduced the increase in the number of reference and working memory errors in the Abeta-infused rats, and increased both the cortico-hippocampal level of DHA and the molar ratio of DHA/arachidonic acid, suggesting an amelioration of the impaired spatial cognition learning ability. Furthermore, DHA suppressed the increases in the levels of lipid peroxide and reactive oxygen species in the cerebral cortex and the hippocampus of Abeta-infused rats, suggesting that DHA increases antioxidative defenses. DHA is thus a possible therapeutic agent for ameliorating learning deficiencies due to Alzheimer's disease.

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Authors: Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., & Shido, O.
Affiliations: Shimane University (JP)
Corresponding author: Hashimoto, Michio
ORCID: Hashimoto, Michio
Tanabe, Yoko
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2005-03
Volume: 135
Issue: 3
Pages: 549-555
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/135.3.549
OpenAlex: W2111757144
Cited by: 288
References: 46
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 7 · 2016: 20 · 2015: 25 · 2014: 18 · 2013: 13 · 2012: 17
FWCI: 18.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6547 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: docosahexaenoic acid, Alzheimer's disease, amyloid-beta, spatial learning, memory impairment, omega-3 fatty acids, hippocampus, cerebral cortex, oxidative stress, lipid hydroperoxides, antioxidant defense, reference memory, working memory, 8-arm radial maze
MeSH terms: Alzheimer Disease, Animals, Cognition, Disease Models, Animal, Docosahexaenoic Acids, Learning, Space Perception, Amyloid beta-Peptides, Rats, Wistar, Reactive Oxygen Species, Rats

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Chronic Administration of Docosahexaenoic Acid Ameliorates the Impairment of Spatial Cognition Learning Ability in Amyloid β–Infused Rats

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