Cited by 221Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionBiochemical effects in animals

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

The Pharmacodynamics of L-Arginine

Open access

Böger, Rainer H.·2007·The Journal of Nutrition

DOI 10.1093/jn/137.6.1650s

Open this paper in CoChat — free account Open PDF

Abstract

L-arginine is a precursor for nitric oxide (NO) synthesis. NO is a ubiquitous mediator that is formed by a family of enzymes named NO synthases. In the brain, NO acts as a neurotransmitter; in the immune system, NO acts as a mediator of host defense; and in the cardiovascular system, NO mediates the protective effects of the intact endothelium, acting as a vasodilator and endogenous antiatherogenic molecule. About 5 g of L-arginine is ingested each day in a normal Western diet. L-arginine plasma levels are not significantly reduced in most disease conditions, except end-stage renal failure during hemodialysis treatment. Nonetheless, intravenous or dietary (oral) administration of relatively large doses of L-arginine has been shown to result in enhanced NO formation in subjects with impaired endothelial function at baseline. In several controlled clinical trials, long-term administration of L-arginine has been shown to improve the symptoms of cardiovascular disease. However, in other trials L-arginine was not beneficial, and in a recent study, the authors reported higher mortality of subjects receiving L-arginine than those receiving placebo. Recently it became clear that endogenous levels of asymmetric dimethylarginine (ADMA), a competitive inhibitor of L-arginine metabolism by NO synthase, may determine a subject's response to L-arginine supplementation. L-arginine appears to exert no effect in subjects with low ADMA levels, whereas in subjects with high ADMA levels, L-arginine restores the L-arginine/ADMA ratio to normal levels and thereby normalizes endothelial function. In conclusion, the effects of L-arginine supplementation on human physiology appear to be multicausal and dose-related. Doses of 3-8 g/d appear to be safe and not to cause acute pharmacologic effects in humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/jn/137.6.1650s

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.
Förstermann, U., Closs, E. I., Pollock, J. S., Nakane, M., Schwarz, P., Gath, I., & Kleinert, H. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.1121 · Cited by 1,122
Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
Drexler, H., Zeiher, A. M., Meinzer, K., & Just, H. (1991) · The Lancet · doi:10.1016/0140-6736(91)92372-9 · Cited by 794
NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease
Cooke, J. P., & Dzau, V. J. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.489 · Cited by 706
Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III)
Förstermann, U., Boissel, J., & Kleinert, H. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.773 · Cited by 647
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
Berkowitz, D. E., White, R., Li, D., Minhas, K. M., Cernetich, A., Kim, S., Burke, S., Shoukas, A. A., Nyhan, D., Champion, H. C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000092948.04444.c7 · Cited by 486
LDL Cholesterol Upregulates Synthesis of Asymmetrical Dimethylarginine in Human Endothelial Cells
Böger, R. H., Sydow, K., Borlak, J. T., Thum, T., Lenzen, H., Schubert, B., Tsikas, D., & Bode‐Böger, S. M. (2000) · Circulation Research · doi:10.1161/01.res.87.2.99 · Cited by 478
Self-citation
Nitric oxide and atherosclerosis: An update
Claudio Napoli, A., de Nigris, F., Williams‐Ignarro, S., Pignalosa, O., Sica, V., & Ignarro, L. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.03.011 · Cited by 471
THE NUTRITIVE SIGNIFICANCE OF THE AMINO ACIDS
Rose, W. C. (1938) · Physiological Reviews · doi:10.1152/physrev.1938.18.1.109 · Cited by 462

Show all 61 references

Research works printed but not linked: 2

Bode-Böger, 1998, Pharmacokinetic-pharmacodynamic relationship of the effects of intravenous and oral L-arginine on nitric oxide formation and peripheral haemodynamics in healthy human subjects, Br J Clin Pharmacol., 46, 489
Maas, 2005, Pharmacotherapeutic interventions and their influence on ADMA levels, Vasc Med., 10, S49, 10.1177/1358836X0501000108 · DOI

Sorted by citations

Strategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Myeloid Cell-Derived Arginase in Cancer Immune Response
Grzywa, T. M., Sosnowska, A., Matryba, P., Rydzyńska, Z., Jasiński, M., Nowis, D., & Gołąb, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00938 · Cited by 446
Arginine de novo and nitric oxide production in disease states
Luiking, Y. C., Have, G. A. M. T., Wolfe, R. R., & Deutz, N. E. P. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2012 · Cited by 250
Mitochondrial diseases: from molecular mechanisms to therapeutic advances
Wen, H., Deng, H., Li, B., Chen, J., Zhu, J., Zhang, X., Yoshida, S., & Zhou, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02044-3 · Cited by 284
Obesity, Inflammation, and the Potential Application of Pharmaconutrition
Cave, M. C., Hurt, R. T., Frazier, T. H., Matheson, P. J., Garrison, R. N., McClain, C. J., & McClave, S. A. (2008) · Nutrition in Clinical Practice · doi:10.1177/011542650802300116 · Cited by 192
Asymmetric and Symmetric Dimethylarginine as Risk Markers for Total Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies
Schlesinger, S., Sonntag, S. R., Lieb, W., & Maas, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165811 · Cited by 171
Prevention of Atherosclerosis by Interference with the Vascular Nitric Oxide System
Li, H., & Förstermann, U. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789058002 · Cited by 154
L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut
Nüse, B., Holland, T., Rauh, M., Gerlach, R. G., & Mattner, J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2222961 · Cited by 135
Therapeutic regimen of l-arginine for MELAS: 9-year, prospective, multicenter, clinical research
Koga, Y., Povalko, N., Inoue, E., Nakamura, H., Ishii, A., Suzuki, Y., Yoneda, M., Kanda, F., Kubota, M., Okada, H., et al. (2018) · Journal of Neurology · doi:10.1007/s00415-018-9057-7 · Cited by 98
Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy
Zhang, Y., Janssens, S. P., Wingler, K., Schmidt, H. H. H. W., & Moens, A. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01315.2010 · Cited by 99
The Potential of L-Arginine in Prevention and Treatment of Disturbed Carbohydrate and Lipid Metabolism—A Review
Szlas, A., Kurek, J. M., & Krejpcio, Z. (2022) · Nutrients · doi:10.3390/nu14050961 · Cited by 100
Health-promoting approaches of the use of chia seeds
Motyka, S., Skała, E., Ekiert, H., & Szopa, A. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105480 · Cited by 90
Nutrition Therapy of the Severely Obese, Critically Ill Patient
McClave, S. A., Kushner, R. F., Way, C. W. V., Cave, M. C., DeLegge, M. H., DiBaise, J. K., Dickerson, R. N., Drover, J., Frazier, T. H., Fujioka, K., et al. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111415111 · Cited by 90
Proteomics and Metabolomics for AKI Diagnosis
Marx, D., Metzger, J., Pejchinovski, M., Gil, R., Frantzi, M., Latosińska, A., Belczacka, I., Heinzmann, S. S., Husi, H., Zoidakis, J., et al. (2017) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2017.09.007 · Cited by 89
Reference Intervals for Plasma L-Arginine and the L-Arginine:Asymmetric Dimethylarginine Ratio in the Framingham Offspring Cohort
Lüneburg, N., Xanthakis, V., Schwedhelm, E., SULLIVAN, L. M., Maas, R., Anderssohn, M., Riederer, U., Glazer, N. L., Vasan, R. S., & Böger, R. H. (2011) · Journal of Nutrition · doi:10.3945/jn.111.148197 · Cited by 86
Self-citation
L-arginine and Alzheimer's disease.
Yi, J., Horky, L. L., Friedlich, A. L., Shi, Y., Rogers, J. T., & Huang, X. (2009) · PubMed · Cited by 85
The Effects of Probiotic Lactobacillus and Bifidobacterium Strains on Memory and Learning Behavior, Long-Term Potentiation (LTP), and Some Biochemical Parameters in β-Amyloid-Induced Rat’s Model of Alzheimer’s Disease
Rezaeiasl, Z., Salami, M., & Sepehri, G. (2019) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2019.24.3.265 · Cited by 78
Effect of a long‐term oral l ‐arginine supplementation on glucose metabolism: a randomized, double‐blind, placebo‐controlled trial
Monti, L. D., Setola, E., Lucotti, P., Marrocco-Trischitta, M. M., Comola, M., Galluccio, E., Poggi, A. D., Mammì, S., Catapano, A. L., Comı, G., et al. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01615.x · Cited by 79
Parenteral or Enteral Arginine Supplementation Safety and Efficacy
Rosenthal, M. D., Carrott, P. W., Patel, J. J., Kiraly, L. N., & Martindale, R. G. (2016) · Journal of Nutrition · doi:10.3945/jn.115.228544 · Cited by 73
Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings
Weckman, A. M., McDonald, C. R., Baxter, J. B., Fawzi, W. W., Conroy, A. L., & Kain, K. C. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz015 · Cited by 74
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine
Kajimoto, H., Kai, H., Aoki, H., Yasuoka, S., Anegawa, T., Aoki, Y., Ueda, S., Okuda, S., & Imaizumi, T. (2012) · Kidney International · doi:10.1038/ki.2011.476 · Cited by 72
Immunity boosting nutraceuticals: Current trends and challenges
Basak, S., & Gokhale, J. S. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13902 · Cited by 77
L-arginine biosensors: A comprehensive review
Verma, N., Singh, A. K., & Singh, M. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2017.10.006 · Cited by 68
The Role of Asymmetric Dimethylarginine and Arginine in the Failing Heart and Its Vasculature
Visser, M., Paulus, W. J., Vermeulen, M. A. R., Richir, M. C., Davids, M., Wisselink, W., de Mol, B. A. J. M., & van Leeuwen, P. A. M. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq158 · Cited by 66
Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
Hosseini, M., Dastghaib, S. S., Rafatpanah, H., Hadjzadeh, M. A.-R., Nahrevanian, H., & Farrokhi, I. (2010) · Clinics · doi:10.1590/s1807-59322010001100021 · Cited by 65
Simultaneous quantitative determination of NG,NG-dimethyl-l-arginine or asymmetric dimethylarginine and related pathway's metabolites in biological fluids by ultrahigh-performance liquid chromatography/electrospray ionization-tandem mass spectrometry
Gangi, I. M. D., Chiandetti, L., Gucciardi, A., Moret, V., Naturale, M., & Giordano, G. (2010) · Analytica Chimica Acta · doi:10.1016/j.aca.2010.08.011 · Cited by 66
Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study
Siegerink, B., Maas, R., Vossen, C. Y., Schwedhelm, E., Köenig, W., Böger, R. H., Rothenbacher, D., Brenner, H., & Breitling, L. P. (2012) · Clinical Research in Cardiology · doi:10.1007/s00392-012-0515-4 · Cited by 63
Self-citation
Chronic Critical Illness: Application of What We Know
Rosenthal, M. D., Kamel, A. Y., Rosenthal, C. M., Brakenridge, S. C., Croft, C. A., & Moore, F. A. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10024 · Cited by 64
L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation
Kurhaluk, N., & Tkaczenko, H. (2025) · Nutrients · doi:10.3390/nu17040665 · Cited by 62
Giardia duodenalis Arginine Deiminase Modulates the Phenotype and Cytokine Secretion of Human Dendritic Cells by Depletion of Arginine and Formation of Ammonia
Banik, S., Viveros, P. R., Seeber, F., Klotz, C., Ignatius, R., & Aebischer, T. (2013) · Infection and Immunity · doi:10.1128/iai.00004-13 · Cited by 62
Roles of Oxidants, Nitric Oxide, and Asymmetric Dimethylarginine in Endothelial Function
Siekmeier, R., Grammer, T. B., & März, W. (2008) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248408326488 · Cited by 59
Chia—The New Golden Seed for the 21st Century
Orona‐Tamayo, D., Valverde, M. E., & Paredes‐López, O. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802778-3.00017-2 · Cited by 61
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy
Shibata, R., Ueda, S., Yamagishi, S., Kaida, Y., Matsumoto, Y., Fukami, K., Hayashida, A., Matsuoka, H., Kato, S., Kimoto, M., et al. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn630 · Cited by 52
Posterior Reversible Encephalopathy Syndrome After Transplantation: a Review
Chen, S., Hu, J., Xu, L., Brandon, D., Yu, J., & Zhang, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9560-0 · Cited by 52
Malaria in pregnancy alters l -arginine bioavailability and placental vascular development
McDonald, C. R., Cahill, L. S., Gamble, J. L., Elphinstone, R. E., Gazdzinski, L. M., Zhong, K., Philson, A. C., Madanitsa, M., Kalilani‐Phiri, L., Mwapasa, V., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan6007 · Cited by 49
Kinetics of the utilization of dietary arginine for nitric oxide and urea synthesis: insight into the arginine–nitric oxide metabolic system in humans
Mariotti, F., Petzke, K. J., Bonnet, D., Szézépanski, I., Bos, C., Huneau, J., & Fouillet, H. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.048025 · Cited by 55
cGMP in the Vasculature
Kemp‐Harper, B. K., & Schmidt, H. H. H. W. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68964-5_19 · Cited by 50
Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury
Nakayama, Y., Ueda, S., Yamagishi, S., Obara, N., Taguchi, K., Ando, R., Kaida, Y., Iwatani, R., Kaifu, K., Yokoro, M., et al. (2013) · Kidney International · doi:10.1038/ki.2013.398 · Cited by 48
Secretion of a fungal protease represents a complement evasion mechanism in cerebral aspergillosis
Rambach, G., Dum, D., Mohsenipour, I., Hagleitner, M., Würzner, R., Lass‐Flörl, C., & Speth, C. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.02.010 · Cited by 47
Decreased diabetes risk over 9 year after 18-month oral l-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of l-arginine study)
Monti, L. D., Galluccio, E., Villa, V., Fontana, B., Spadoni, S., & Piatti, P. M. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1548-2 · Cited by 45
Influence of exercise on oxidative stress in patients with heart failure
Sties, S. W., Andreato, L. V., de Carvalho, T., Gonzáles, A. I., Angarten, V. G., Ulbrich, A. Z., de Mara, L. S., Netto, A. S., da Silva, E. L., & Andrade, A. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9686-z · Cited by 44
Protein and amino acid supplementation in older humans
Fukagawa, N. K. (2013) · Amino Acids · doi:10.1007/s00726-013-1480-6 · Cited by 43
l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation
Menzel, D., Haller, H. G., Wilhelm, M. G., & Robenek, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1342-6 · Cited by 43
Comparative study on the composition of free amino acids and derivatives in the two botanical origins of an edible Chinese herb “Xiebai”, i.e., Allium chinense G. Don and Allium macrostemon Bunge species
He, Q., Huang, S., Wu, Y., Zhang, W., Wang, F., Cao, J., Sheng, Q., Liang, Z., Liu, L., & Ou, W. (2018) · Food Research International · doi:10.1016/j.foodres.2018.01.007 · Cited by 41
Asymmetric Dimethylarginine (ADMA) in cardiovascular and renal disease
Alpoim, P. N., Sousa, L. P. N., Mota, A. P. L., Rios, D. R. A., & Dusse, L. M. S. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.11.002 · Cited by 43
The effect of chronic administration of l-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
Hosseini, M., Headari, R., Oryan, S., Hadjzadeh, M. A.-R., Saffarzadeh, F., & Khazaei, M. (2010) · Clinics · doi:10.1590/s1807-59322020000800012 · Cited by 41
Evolving paradigms in the nutritional support of critically ill surgical patients
Rosenthal, M. D., Vanzant, E. L., Martindale, R. G., & Moore, F. A. (2015) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2015.02.003 · Cited by 37
The Role of L-Arginine-NO System in Female Reproduction: A Narrative Review
Bódis, J., Farkas, B., Nagy, B., Kovács, K. A., & Sulyok, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314908 · Cited by 38
Urease-based ISFET biosensor for arginine determination
Sheliakina, M., Arkhypova, V. М., Soldatkin, O. O., Saiapina, O., Akata, B., & Dzyadevych, S. V. (2014) · Talanta · doi:10.1016/j.talanta.2013.12.042 · Cited by 39
Addition of 2.5g l-arginine in a fatty meal prevents the lipemia-induced endothelial dysfunction in healthy volunteers
Borucki, K., Aronica, S., Starke, I., Luley, C. H., & Westphal, S. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.10.026 · Cited by 39
Effects of 7 Days of Arginine-Alpha-Ketoglutarate Supplementation on Blood Flow, Plasma L-Arginine, Nitric Oxide Metabolites, and Asymmetric Dimethyl Arginine After Resistance Exercise
Willoughby, D. S., Boucher, T., Reid, J., Skelton, G., & Clark, M. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.4.291 · Cited by 36
Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements
Davis, J. S., Darcy, C. J., Piera, K. A., McNeil, Y., Woodberry, T., & Anstey, N. M. (2009) · BMC Clinical Pathology · doi:10.1186/1472-6890-9-10 · Cited by 35
Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis
Kakehashi, A., Suzuki, S., Ishii, N., Okuno, T., Kuwae, Y., Fujioka, M., Gi, M., Стефанов, В. Е., & Wanibuchi, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207746 · Cited by 37
Incidence of All-Cause and Cardiovascular Mortality Predicted by Symmetric Dimethylarginine in the Population-Based Study of Health in Pomerania
Schwedhelm, E., Wallaschofski, H., Atzler, D., Dörr, M., Nauck, M. A., Völker, U., Kroemer, H. K., Völzke, H., Böger, R. H., & Friedrich, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096875 · Cited by 33
Self-citation
Antibacterial activity of poly-l-arginine under different conditions.
Sepahi, M., Jalal, R., & Mashreghi, M. (2017) · PubMed Central · Cited by 33
NMR-Based Serum Metabolomics Revealed Distinctive Metabolic Patterns in Reactive Arthritis Compared with Rheumatoid Arthritis
Dubey, D., Kumar, U., Chaurasia, S., Guleria, A., Ahmed, S., Singh, R., Kumari, R., Modi, D. R., Misra, R., & Kumar, D. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00439 · Cited by 32
Free Amino Acids in Botanicals and Botanical Preparations
Carratù, B., Boniglia, C., Giammarioli, S., Mosca, M., & Sanzini, E. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00767.x · Cited by 31
The Association of Dietary l-Arginine Intake and Serum Nitric Oxide Metabolites in Adults: A Population-Based Study
Mirmiran, P., Bahadoran, Z., Ghasemi, A., & Azizi, F. (2016) · Nutrients · doi:10.3390/nu8050311 · Cited by 30
Regulated Arginine Metabolism in Immunopathogenesis of a Wide Range of Diseases: Is There a Way to Pass between Scylla and Charybdis?
Старикова, Э. А., Rubinstein, A., Mammedova, J. T., Isakov, D., & Kudryavtsev, I. V. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040231 · Cited by 30
Flavanol-rich cocoa ameliorates lipemia-induced endothelial dysfunction
Westphal, S., & Luley, C. H. (2010) · Heart and Vessels · doi:10.1007/s00380-010-0085-1 · Cited by 27
l-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats
Lee, C.-W., Li, D., Channon, K. M., & Paterson, D. J. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.03.023 · Cited by 25
Drivers of Oxidative Stress in Acute Pancreatitis
McClave, S. A. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111424410 · Cited by 25
Detrimental effect of oxidized LDL on endothelial arginine metabolism and transportation
Zhang, W., Venardos, K. M., Finch, S., & Kaye, D. M. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.10.027 · Cited by 24
Ethnicity-specific differences in L-arginine status in South African men
Glyn, M., Anderssohn, M., Lüneburg, N., van Rooyen, J. M., Schutte, R., Huisman, H. W., Fourie, C. M. T., Smith, W. T., Malan, L., Malan, N. T., et al. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.103 · Cited by 24
Self-citation
Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique
Lee, S., Lee, J. S., Choi, M. H., Lee, S. E., Shin, D. H., & Hong, J. M. (2017) · BMC Neurology · doi:10.1186/s12883-017-0950-y · Cited by 23
l-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older women
Aguiar, A. F., Balvedi, M. C. W., Buzzachera, C. F., Altimari, L. R., Lozovoy, M. A. B., Bigliassi, M., Januário, R. S. B., Pereira, R. M., Sanches, V. C., da Silva, D. K., et al. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-1019-6 · Cited by 21
Impact of the L-arginine-Nitric Oxide Pathway and Oxidative Stress on the Pathogenesis of the Metabolic Syndrome
Assumpção, C. R., Brunini, T. M. C., Matsuura, C., Resende, Â. C., & Mendes-Ribeiro, A. C. (2008) · The Open Biochemistry Journal · doi:10.2174/1874091x00802010108 · Cited by 22
Involvement of l‐arginine‐nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice
Ben‐Azu, B., Aderibigbe, A. O., Ajayi, A. M., Umukoro, S., & Iwalewa, E. O. (2019) · Drug Development Research · doi:10.1002/ddr.21588 · Cited by 21
Metabolic regulation of immune responses to cancer
Wißfeld, J., Werner, A., Yan, X., ten Bosch, N., & Cui, G. (2022) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0381 · Cited by 21
Nutrition before, during, and after surgery increases the arginine:asymmetric dimethylarginine ratio and relates to improved myocardial glucose metabolism: a randomized controlled trial
Visser, M., Davids, M., Verberne, H. J., Kok, W. E. M., Tepaske, R., Cocchieri, R., Kemper, E. M., Teerlink, T., Jonker, M. A., Wisselink, W., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.075473 · Cited by 20
Effect of spironolactone for 1 yr on endothelial function and vascular inflammation biomarkers in renal transplant recipients
Mortensen, L. A., Bistrup, C., Stubbe, J., Carlström, M., Checa, A., Wheelock, C. E., Palarasah, Y., Bladbjerg, E., Thiesson, H. C., & Jensen, B. L. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00025.2019 · Cited by 20
Habitual intake of dietary L-arginine in relation to risk of type 2 diabetes: a prospective study
Mirmiran, P., Bahadoran, Z., Gaeini, Z., & Azizi, F. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00774-x · Cited by 20
Metabolic improvements of novel microbial fermentation on black tea by Eurotium cristatum
Wang, X., Shan, R.-Y., Li, Z.-L., Kong, X., Hou, R.-T., Wu, H.-N., & Chen, C. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1287802 · Cited by 19
Biomarkers in immunonutrition programme, is there still a need for new ones? A brief review
Forget, P., Echeverria, G., Giglioli, S., Bertrand, B., Nikis, S., Lechat, J.-P., & Kock, M. D. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.546 · Cited by 19
Single- and multiple-dose pharmacokinetics of arginase inhibitor Nω-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats
Havlínová, Z., Hroch, M., Nagy, A., Šišpera, L., Holeček, M., & Chládek, J. (2014) · General Physiology and Biophysics · doi:10.4149/gpb_2013078 · Cited by 19
l-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides
Schulze, F., Glos, S., Petruschka, D., Altenburg, C., Maas, R., Benndorf, R. A., Schwedhelm, E., Beil, U., & Böger, R. H. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.04.004 · Cited by 18
Self-citation
l -arginine Supplementation Increased Only Endothelium-Dependent Relaxation in Sprague-Dawley Rats Fed a High-Salt Diet by Enhancing Abdominal Aorta Endothelial Nitric Oxide Synthase Gene Expression
Adejare, A. A., Oloyo, A. K., Anigbogu, C. N., & Jaja, S. I. (2020) · Clinical Medicine Insights Cardiology · doi:10.1177/1179546820902843 · Cited by 18
Role of melatonin mediated G-CSF induction in hematopoietic system of gamma-irradiated mice
Kumar, A., Choudhary, S., Kumar, S., Adhikari, J. S., Kapoor, S., & Chaudhury, N. K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120190 · Cited by 18
Advances in Fabrication Technologies for the Development of Next-Generation Cardiovascular Stents
Das, A., Mehrotra, S., & Kumar, A. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14110544 · Cited by 17
Inducible nitric oxide synthase inhibitor aminoguanidine, differently affects Morris water maze tasks of ovariectomized and naïve female rats
Hosseini, M., Karimooy, H. N., Hadjzadeh, M., & Safari, V. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.4.5 · Cited by 17
The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
Mels, C. M. C., Huisman, H. W., Smith, W. T., Schutte, R., Schwedhelm, E., Atzler, D., Böger, R. H., Ware, L. J., & Schutte, A. E. (2016) · AGE · doi:10.1007/s11357-016-9873-6 · Cited by 17
Self-citation
Effects of Vitamin D3 on asymmetric- and symmetric dimethylarginine in arterial hypertension
Grübler, M. R., Gaksch, M., Kienreich, K., Verheyen, N., Schmid, J., Müllner, C., Richtig, G., Scharnagl, H., Trummer, C., Schwetz, V., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.12.014 · Cited by 19
Effects of Acute and Chronic Stress on the L-Arginine Nitric Oxide Pathway in Black and White South Africans
Reimann, M., Hamer, M., Malan, N. T., Schlaich, M. P., Lambert, G. W., Ziemssen, T., Boeger, R. H., & Malan, L. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182a3e465 · Cited by 16
Chronic treatment with the nitric oxide synthase inhibitor, L-NAME, attenuates estradiol-mediated improvement of learning and memory in ovariectomized rats
Azizi-Malekabadi, H., Hosseini, M., Saffarzadeh, F., Karami, R., & Khodabandehloo, F. (2011) · Clinics · doi:10.1590/s1807-59322011000400024 · Cited by 16
Human arginase 1, a Jack of all trades?
Anakha, J., Kawathe, P. S., Datta, S., Jawalekar, S. S., Banerjee, U. C., & Pande, A. H. (2022) · 3 Biotech · doi:10.1007/s13205-022-03326-9 · Cited by 18
Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion
Hsieh, K.-F., Shih, J.-M., Shih, Y.-M., Pai, M., & Yeh, S. (2018) · Nutrition · doi:10.1016/j.nut.2018.02.019 · Cited by 16
Pre-clinical Research on Bladder Toxicity After Radiotherapy for Pelvic Cancers: State-of-the Art and Challenges
Zuppone, S., Bresolin, A., Spinelli, A. E., Fallara, G., Lucianò, R., Scarfò, F., Benigni, F., Muzio, N. G. D., Fiorino, C., Briganti, A., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.527121 · Cited by 17
Rational design to improve the catalytic efficiency and stability of arginine deiminase
Zhang, Y., Zhang, T., Li, M., & Miao, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132083 · Cited by 15
Biomarkers in Hemodialysis Patients
Hojs, R., Bevc, S., & Ekart, R. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394384-2.00002-4 · Cited by 15
Independent spectral characteristics of functionalized silver nanoparticles for colorimetric assay of arginine and spermine in biofluids
Kailasa, S. K., Desai, M. L., Baek, S. H., Tu, L. M. T. P. P. L. M., Nguyen, T. P., Rafique, R., & Park, T. J. (2019) · New Journal of Chemistry · doi:10.1039/c9nj04132j · Cited by 15
Clinical guidelines and nutrition therapy: better understanding and greater application to patient care.
McClave, S., & Hurt, R. (2010) · Critical care clinics · doi:10.1016/j.ccc.2010.04.008 · Cited by 14
Palmolein and olive oil consumed within a high protein test meal have similar effects on postprandial endothelial function in overweight and obese men: A randomized controlled trial
Stonehouse, W., Brinkworth, G. D., & Noakes, M. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.009 · Cited by 15
Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?
Rubio-Guerra, A. F. (2010) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s7479 · Cited by 15
A Slow- Compared with a Fast-Release Form of Oral Arginine Increases Its Utilization for Nitric Oxide Synthesis in Overweight Adults with Cardiometabolic Risk Factors in a Randomized Controlled Study
Deveaux, A., Fouillet, H., Petzke, K. J., Hermier, D., André, E., Bunouf, P., Lantoine, F., Benamouzig, R., Mathé, V., Huneau, J., et al. (2016) · Journal of Nutrition · doi:10.3945/jn.116.231910 · Cited by 15
Effects of incretin agonists on endothelial nitric oxide synthase expression and nitric oxide synthesis in human coronary artery endothelial cells exposed to TNFα and glycated albumin
Garczorz, W., Francuz, T., Siemianowicz, K., Kosowska, A., Kłych, A., Aghdam, M. R. F., & Jagoda, K. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.08.007 · Cited by 12
Endothelial dysfunction in the pathogenesis of arterial hypertension and the progression of atherosclerosis
Пузік, С. Г. (2018) · Family Medicine · doi:10.30841/2307-5112.2.2018.145561 · Cited by 12
Early malnutrition, but not age, modulates in the rat the l-Arginine facilitating effect on cortical spreading depression
de Melo, M. F. F. T., Maia, L. M. S. D. S., & Guedes, R. C. A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.068 · Cited by 12
Fibroblasts mediate endothelium response to angiogenic cues in a newly developed 3D stroma engineered model
Dellaquila, A., Dujardin, C., Bao, C. L., Chaumeton, C., Carré, A., Guilcher, C. L., Lam, F., & Simón‐Yarza, T. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213636 · Cited by 12
Compositional and nutritional evaluation of viscera from commercially harvested wild-caught Australian abalones (Haliotis spp.)
Chung, W. H., Coorey, R., Takechi, R., & Howieson, J. (2023) · LWT · doi:10.1016/j.lwt.2023.115590 · Cited by 11

Authors: Böger, R. H.
Affiliations: University Medical Center Hamburg-Eppendorf (DE)
Corresponding author: Böger, Rainer H.
ORCID: Böger, Rainer H.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2007-06
Volume: 137
Issue: 6
Pages: 1650S-1655S
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/137.6.1650s
OpenAlex: W2115875498
Cited by: 221
References: 61
Citations by year: 2026: 14 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 14 · 2017: 11 · 2016: 16 · 2015: 11 · 2014: 12 · 2013: 13 · 2012: 12
FWCI: 1.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5734 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Deutsche Herzstiftung
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
Keywords: L-arginine, nitric oxide, nitric oxide synthase, asymmetric dimethylarginine, endothelial function, cardiovascular disease, dietary supplementation, pharmacodynamics, dose-response relationship, end-stage renal disease, vasodilation, antiatherogenic effects
MeSH terms: Arginine, Cardiovascular Diseases, Humans, Nitric Oxide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Pharmacodynamics of L-Arginine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks