The DOI matches its Crossref record.
Epidemiology of Cancer of the Pancreas2
Abstract
Despite the fact that cancer of the pancreas constitutes the fourth leading cause of cancer deaths in the United States, it has long been neglected by epidemiologists. This is a retrospective study undertaken in 142 patients with adenocarcinoma of the pancreas, 11 with islet cell cancer, and 10 with cancer of the ampulla of Vater. The results were evaluated and interpreted in line with a review of the literature. The data indicated that this cancer predominated among males, particularly at ages under 50, and was significantly associated with cigarette smoking. There was a suggestive association with cigar smoking. Among females, a significant relationship to early-onset diabetes was found, and an association with a history of chclecystectomy was suggested. Based on the epidemiologic and pathologic data, a working hypothesiswas presented: The bile might contain carcinogens originating fromtobacco, occupational environment, and possibly diet, and cause cancer on reflux into the pancreatic duct.
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Citations
Cited by
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R. W., Lankisch, P. G., Andersen, J. R., Dimagno, E. P., Andren-Sandberg, A., & Domellof, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,757
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602619 · Cited by 1,105
Epidemiology and risk factors for pancreatic cancer
Lowenfels, A. B., & Maisonneuve, P. (2006) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.10.001 · Cited by 635
Bile acids as carcinogens in human gastrointestinal cancers
Bernstein, H., Bernstein, C., Payne, C. M., Dvorakova, K., & Garewal, H. (2005) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.08.001 · Cited by 611
Coffee and Cancer of the Pancreas
MacMahon, B., Yen, S., Trichopoulos, D., Warren, K., & Nardi, G. (1981) · New England Journal of Medicine · doi:10.1056/nejm198103123041102 · Cited by 451
Metadata
- Authors
- Wynder, E. L., Mabuchi, K., Maruchi, N., & Fortner, J. G.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-03
- Volume
- 50
- Issue
- 3
- Pages
- 645-667
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2265537752
- Cited by
- 248
- References
- 0
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Epidemiology of Cancer of the Pancreas2. https://app.cochat.ai/papers/10.1093/jnci/50.3.645
- The paper
- Wynder, E. L., Mabuchi, K., Maruchi, N., & Fortner, J. G. (1973). Epidemiology of Cancer of the Pancreas2. JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/50.3.645
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
