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Cited by 1,105Pancreatic and Hepatic Oncology ResearchMetabolism, Diabetes, and CancerCancer Risks and Factors

Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies

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Huxley, R, Ansary-Moghaddam, A, Berrington de González, A, Barzi, F, Woodward, M·2005·British Journal of Cancer
DOI 10.1038/sj.bjc.6602619PMC PMC2361795
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Abstract

Pancreatic cancer is the eighth major form of cancer-related death worldwide, causing 227 000 deaths annually. Type-II diabetes is widely considered to be associated with pancreatic cancer, but whether this represents a causal or consequential association is unclear. We conducted a meta-analysis to examine this association. A computer-based literature search from 1966 to 2005 yielded 17 case-control and 19 cohort or nested case-control studies with information on 9220 individuals with pancreatic cancer. The age and sex-adjusted odds ratio (OR) for pancreatic cancer associated with type-II diabetes was obtained from each study. The combined summary odds ratio was 1.82 (95% confidence interval (95% CI) 1.66-1.89), with evidence of heterogeneity across the studies (P=0.002 for case-control and P=0.05 for cohort studies) that was explained, in part, by higher risks being reported by smaller studies and studies that reported before 2000. Individuals in whom diabetes had only recently been diagnosed (< 4 years) had a 50% greater risk of the malignancy compared with individuals who had diabetes for > or =5 years (OR 2.1 vs 1.5; P=0.005). These results support a modest causal association between type-II diabetes and pancreatic cancer.

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  • More than 50% of PDAC is accompanied by diabetes at the time of diagnosis.

    “and more than 50% of PDAC is accompanied by diabetes at the time of diagnosis.212”

    From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [212]

    The paper’s introductory passage says type-II diabetes frequently occurs with pancreatic cancer, and the Discussion describes diabetes diagnosed shortly before the malignancy. Neither passage gives the proportion of pancreatic cancer patients with diabetes at diagnosis, so the claim that it exceeds 50% is unsupported. The paper’s 50% figures concern relative risk, not prevalence. (LLM, conf=0.82)

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Authors
Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M.
Affiliations
The University of Sydney (AU)
Corresponding author
Huxley, R
ORCID
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
2005-05-10
Volume
92
Issue
11
Pages
2076-2083
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/sj.bjc.6602619
PMC
PMC2361795
OpenAlex
W2066809635
Cited by
1,105
References
4
Citations by year
2026: 23 · 2025: 33 · 2024: 22 · 2023: 41 · 2022: 45 · 2021: 47 · 2020: 50 · 2019: 54 · 2018: 53 · 2017: 59 · 2016: 61 · 2015: 69 · 2014: 70 · 2013: 85 · 2012: 82
FWCI
3.49
Type
journal article
Language
en
Open access
Licence
Locations
  • British Journal of Cancer (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
type 2 diabetes, pancreatic cancer, diabetes and cancer risk, causal relationship, diabetes duration, pancreatic cancer risk factors
MeSH terms
Diabetes Mellitus, Type 2, Humans, Pancreatic Neoplasms, Risk Factors, Time Factors, Cohort Studies, Odds Ratio, Case-Control Studies

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