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Neoplastic and Nonneoplastic Lesions in Aging (C57BL/6N × C3H/HeN)F1 (B6C3F1) Mice2
Abstract
Neoplastic and nonneoplastic lesions in untreated (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice used as controls in carcinogenesis tests were tabulated and evaluated. The most common neoplasms in 2,543 male mice were hepatocellular adenomas and carcinomas. In 2,522 female mice, common tumors were lymphomas, leukemias, pulmonary adenomas and carcinomas, hepatocellular adenomas and carcinomas, and pituitary adenomas. The risk of developing most neoplasms increased with the age of the mouse. Hepatocellular carcinomas metastasized in 12% of the animals with these tumors. Other than lymphomas and leukemias, few other tumors metastasized. Nonneoplastic lesions included cystic hyperplasia of the uterus, nephritis, ovarian and uterine cysts, inflammatory lesions of the lung, mineralization in the brain, and focal hyperplasias in several tissues. The focal hyperplasias in lung and pituitary, adrenal, and thyroid glands were suggestive of the early stages of neoplasia. Comparative aspects of lesions in aging mice and their interpretation in carcinogenesis tests are discussed.
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Cited by
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Self-citationSpontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
Kim, I., Morimura, K., Shah, Y., Yang, Q., Ward, J. M., & Gonzalez, F. J. (2007) · Carcinogenesis · doi:10.1093/carcin/bgl249 · Cited by 357
Self-citationUse of Historical Control Data in Carcinogenicity Studies in Rodents
Haseman, J. K., Huff, J., & Boorman, G. A. (1984) · Toxicologic Pathology · doi:10.1177/019262338401200203 · Cited by 317
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Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument
Mecklenburg, L., Kusewitt, D., Kolly, C., Treumann, S., Adams, E. T., Diegel, K., Yamate, J., Kaufmann, W., Müller, S., Danilenko, D., et al. (2013) · Journal of Toxicologic Pathology · doi:10.1293/tox.26.27s · Cited by 81
Metadata
- Authors
- Ward, J. M., Goodman, D. G., Squire, R. A., Chu, K. C., & Linhart, M. S.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1979-09
- Volume
- 63
- Issue
- 3
- Pages
- 849-854
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2108860907
- Cited by
- 243
- References
- 0
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neoplastic and Nonneoplastic Lesions in Aging (C57BL/6N × C3H/HeN)F1 (B6C3F1) Mice2. https://app.cochat.ai/papers/10.1093/jnci/63.3.849
- The paper
- Ward, J. M., Goodman, D. G., Squire, R. A., Chu, K. C., & Linhart, M. S. (1979). Neoplastic and Nonneoplastic Lesions in Aging (C57BL/6N × C3H/HeN)F1 (B6C3F1) Mice2. JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/63.3.849
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