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Carcinogenicity of Butylated Hydroxyanisole in F344 Rats 234
Abstract
Butylated hydroxyanisole (BHA) was added at levels of 0.5 and 2.0% to the diet of inbred F344 rats for 2 years. The higher dose of BHA induced a significant increase in the incidence of papilloma and squamous cell carcinoma in both sexes. Both the higher and lower doses increased the incidences of hyperplasia of the forestomach, considered to be associated with neoplasias. The incidences of these neoplastic changes were dose-dependent. Neoplastic changes in other organs were not increased significantly by BHA. These results show that BHA is carcinogenic in the forestomach of F344 rats.
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Cited by
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The antioxidative properties of holy basil and galangal in cooked ground pork
Juntachote, T., Berghofer, E., Siebenhandl, S., & Bauer, F. (2006) · Meat Science · doi:10.1016/j.meatsci.2005.08.009 · Cited by 199
Tel, G., Öztürk, M., Duru, M. E., Harmandar, M., & Topçu, G. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.08.020 · Cited by 63
Metadata
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-02
- Volume
- 70
- Issue
- 2
- Pages
- 343-52
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W1826417692
- Cited by
- 544
- References
- 0
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carcinogenicity of Butylated Hydroxyanisole in F344 Rats 234. (1983). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/70.2.343
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