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Quality of Life End Points in Cancer Clinical Trials: Review and Recommendations
Open accessAbstract
In this presentation, issues that influenced the development of policies for inclusion of quality of life end points in certain Southwest Oncology Group clinical trials are reviewed. The key policies recommended by us and adopted by the Cancer Control Research Committee of the Southwest Oncology Group are as follows: (a) Begin assessment of quality of life in specific types of phase III protocols. (b) Always measure physical functioning, emotional functioning, symptoms (general and protocol specific), and global quality of life separately. (c) Include measures of social functioning and additional protocol-specific measures if resources permit. (d) Use patient-based questionnaires with psychometric properties that have been documented in published studies. In this review, we also recommend specific questionnaires. Our recommendations may prove useful for other cancer clinical trials groups and for multi-institution trials of treatment for chronic diseases.
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Cited by
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Cella, D. F., Tulsky, D. S., Gray, G., Sarafian, B., Linn, E., Bonomi, A., Silberman, M., Yellen, S. B., Winicour, P., & Brannon, J. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.3.570 · Cited by 6,020
Evaluating patient-based outcome measures for use in clinical trials.
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Effect of computer support on younger women with breast cancer
Gustafson, D. H., Hawkins, R., Pingree, S., McTavish, F., Arora, N. K., Mendenhall, J., Cella, D. F., Serlin, R. C., Apantaku, F. M., Stewart, J., et al. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016007435.x · Cited by 387
Rummans, T. A., Clark, M. M., Sloan, J. A., Frost, M. H., Bostwick, J. M., Atherton, P. J., Johnson, M. E., Gamble, G., Richardson, J., Brown, P., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.209 · Cited by 353
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Metadata
- Authors
- Moinpour, C. M., Feigl, P., Metch, B., Hayden, K. A., Meyskens, F. L., & Crowley, J.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-04-05
- Volume
- 81
- Issue
- 7
- Pages
- 485-496
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2004123506
- Cited by
- 379
- References
- 0
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Quality of Life End Points in Cancer Clinical Trials: Review and Recommendations. https://app.cochat.ai/papers/10.1093/jnci/81.7.485
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- Moinpour, C. M., Feigl, P., Metch, B., Hayden, K. A., Meyskens, F. L., & Crowley, J. (1989). Quality of Life End Points in Cancer Clinical Trials: Review and Recommendations. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/81.7.485
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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