Impacting quality of life for patients with advanced cancer with a structured multidisciplinary intervention: a randomized controlled trial
Open accessAbstract
Purpose: The primary goal of this study was to evaluate the feasibility and effectiveness of a structured, multidisciplinary intervention targeted to maintain the overall quality of life (QOL), which is more comprehensive than psychosocial distress, of patients undergoing radiation therapy for advanced-stage cancer. Patients and Methods: Radiation therapy patients with advanced cancer and an estimated 5-year survival rate of 0% to 50% were randomly assigned to either an eight-session structured multidisciplinary intervention arm or a standard care arm. The eight 90-minute sessions addressed the five domains of QOL including cognitive, physical, emotional, spiritual, and social functioning. The primary end point of maintaining overall QOL was assessed by a single-item linear analog scale (Linear Analog Scale of Assessment or modified Spitzer Uniscale). QOL was assessed at baseline, week 4 (end of multidisciplinary intervention), week 8, and week 27. Results: Of the 103 participants, overall QOL at week 4 was maintained by the patients in the intervention (n = 49), whereas QOL at week 4 significantly decreased for patients in the control group (n = 54). This change reflected a 3-point increase from baseline in the intervention group and a 9-point decrease from baseline in the control group (P = .009). Intervention participants maintained their QOL, and controls gradually returned to baseline by the end of the 6-month follow-up period. Conclusion: Although intervention participants maintained and actually improved their QOL during radiation therapy, control participants experienced a significant decrease in their QOL. Thus, a structured multidisciplinary intervention can help maintain or even improve QOL in patients with advanced cancer who are undergoing cancer treatment.
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Rummans et al. implemented a structured multidisciplinary intervention targeting five QOL domains (cognitive, emotional, physical, social, spiritual) with advanced cancer patients undergoing radiation therapy.
“Rummans et al.24 implemented a structured multidisciplinary intervention targeting five QOL domains (cognitive, emotional, physical, social and spiritual) with advanced cancer patients undergoing radiation therapy.”
From Self-management: Enabling and empowering patients living with cancer as a chronic illness (2011) · cites this paper as [24]
Participants in the intervention group reported similar QOL scores at follow-up six months later (p=.992).
“Further, participants in the intervention group reported similar QOL scores at follow-up six months later (p=.992).24”
From Self-management: Enabling and empowering patients living with cancer as a chronic illness (2011) · cites this paper as [24]
Even in advanced cancer, intervention patients reported stable QOL outcomes by four weeks compared to control group patients who experienced a significant decline in QOL at week four (p=.046).
“Even in the context of advanced cancer, the intervention patients reported stable QOL outcomes by four weeks in comparison to control group patients who experienced a significant decline in QOL at week four (p=.046).”
From Self-management: Enabling and empowering patients living with cancer as a chronic illness (2011) · cites this paper as [24]
Intervention sessions addressed self-management components including goal-setting, taking charge, problem-solving, redirecting negative thoughts, building interpersonal relationships, and managing emotional and spiritual responses.
“Intervention sessions addressed components of SM, including goal-setting, taking charge, problem-solving, redirecting negative thoughts, building interpersonal relationships, and managing emotional and spiritual responses.”
From Self-management: Enabling and empowering patients living with cancer as a chronic illness (2011) · cites this paper as [24]
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- Authors
- Rummans, T. A., Clark, M. M., Sloan, J. A., Frost, M. H., Bostwick, J. M., Atherton, P. J., Johnson, M. E., Gamble, G., Richardson, J., Brown, P., Martensen, J., Miller, J., Piderman, K., Huschka, M., Girardi, J., & Hanson, J.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2006-02-01
- Volume
- 24
- Issue
- 4
- Pages
- 635-642
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2126233165
- Cited by
- 353
- References
- 59
- Citations by year
- 2026: 1 · 2025: 12 · 2024: 9 · 2023: 19 · 2022: 16 · 2021: 16 · 2020: 24 · 2019: 17 · 2018: 15 · 2017: 22 · 2016: 23 · 2015: 28 · 2014: 17 · 2013: 26 · 2012: 25
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Keywords
- quality of life, advanced cancer, radiotherapy, multidisciplinary intervention, psychosocial support, cancer patients, feasibility, emotional functioning, social functioning, cognitive function, physical function
- MeSH terms
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Cognition, Emotions, Feasibility Studies, Humans, Male, Middle Aged, Neoplasms, Patient Care Team, Quality of Life, Surveys and Questionnaires, Role, Treatment Outcome, Spirituality
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