The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Open accessAbstract
Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction of tumor cell senescence is also one of the underlying mechanisms by which cancer therapies exert antitumor activity. However, an increasing body of evidence from preclinical studies demonstrates that radiation and chemotherapy cause accumulation of senescent cells (SnCs) both in tumor and normal tissue. SnCs in tumors can, paradoxically, promote tumor relapse, metastasis, and resistance to therapy, in part, through expression of the senescence-associated secretory phenotype. In addition, SnCs in normal tissue can contribute to certain radiation- and chemotherapy-induced side effects. Because of its multiple roles, cellular senescence could serve as an important target in the fight against cancer. This commentary provides a summary of the discussion at the National Cancer Institute Workshop on Radiation, Senescence, and Cancer (August 10-11, 2020, National Cancer Institute, Bethesda, MD) regarding the current status of senescence research, heterogeneity of therapy-induced senescence, current status of senotherapeutics and molecular biomarkers, a concept of “one-two punch” cancer therapy (consisting of therapeutics to induce tumor cell senescence followed by selective clearance of SnCs), and its integration with personalized adaptive tumor therapy. It also identifies key knowledge gaps and outlines future directions in this emerging field to improve treatment outcomes for cancer patients.
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Metadata
- Authors
- Prasanna, P. G., Citrin, D. E., Hildesheim, J., Ahmed, M. M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., Deursen, J. V., Goronzy, J., Kron, S. J., Anscher, M. S., Sharpless, N. E., Campisi, J., Brown, S. L., Niedernhofer, L. J., O’Loghlen, A., Georgakilas, A. G., Paris, F., Gius, D., Gewirtz, D. A., Schmitt, C. A., Abazeed, M. E., Kirkland, J. L., Richmond, A., Romesser, P. B., Lowe, S. W., Gil, J., Mendonca, M. S., Burma, S., Zhou, D., & Coleman, C. N.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-04-01
- Volume
- 113
- Issue
- 10
- Pages
- 1285-1298
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W3146830857
- Cited by
- 348
- References
- 135
- FWCI
- 28.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Funders
- National Cancer Institute (P30CA060553, R37CA222294, RO1 CA197796, R01 CA246807, 1R01CA214025-01, RO1CA239706, AG063543, ES029603, AG056278, P01AG062413, R01CA164492, R01CA217182, CA116021, R37CA233770, R37AG013925, R33AG061456, P30CA008748, K12 CA184746, R01CA211963, R01CA219836, R01CA242003, R01AG063801, R01CA218596, R21CA205660, BC10850)
- National Aeronautics and Space Administration (NNX16AD78G)
- Avon Foundation for Breast Cancer Research and the Lynn Sage Cancer Research Foundation
- MRC (MC-U120085810)
- Worldwide Cancer Research (18- 0215)
- CRUK (C15075/A28647)
- Kirkland’s laboratory
- Alzheimer’s Association Part the Cloud Program, Robert and Arlene Kogod
- Connor Group, Robert J. and Theresa W. Ryan
- Noaber Foundation
- BBSRC (BB/P000223/1)
- Barts Charity Grant (MGU0497)
- VA MERIT Award (101BX002301)
- VA Senior Research Career Scientist Award
- Deutsche Krebshilfe (110678)
- BMBF e: Med program project SeneSys (031L0189A)
- Deutsche Forschungsgemeinschaft DFG (GO 2688/1-1 | SCHM 1633/11-1, SCHM 1633/9-1)
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- Prasanna, P. G., Citrin, D. E., Hildesheim, J., Ahmed, M. M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., Deursen, J. V., Goronzy, J., Kron, S. J., Anscher, M. S., Sharpless, N. E., Campisi, J., Brown, S. L., Niedernhofer, L. J., O’Loghlen, A., Georgakilas, A. G., Paris, F., . . . Coleman, C. N. (2021). Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/djab064
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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