Cited by 301Selenium in Biological SystemsNonmelanoma Skin Cancer StudiesHead and Neck Cancer Studies

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Selenium Supplementation and Secondary Prevention of Nonmelanoma Skin Cancer in a Randomized Trial

Duffield-Lillico, A. J.·2003·CancerSpectrum Knowledge Environment

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Abstract

The Nutritional Prevention of Cancer Trial was a double-blind, randomized, placebo-controlled clinical trial designed to test whether selenium as selenized yeast (200 microg daily) could prevent nonmelanoma skin cancer among 1312 patients from the Eastern United States who had previously had this disease. Results from September 15, 1983, through December 31, 1993, showed no association between treatment and the incidence of basal and squamous cell carcinomas of the skin. This report summarizes the entire blinded treatment period, which ended on January 31, 1996. The association between treatment and time to first nonmelanoma skin cancer diagnosis and between treatment and time to multiple skin tumors overall and within subgroups, defined by baseline characteristics, was evaluated. Although results through the entire blinded period continued to show that selenium supplementation was not statistically significantly associated with the risk of basal cell carcinoma (hazard ratio [HR] = 1.09, 95% confidence interval [CI] = 0.94 to 1.26), selenium supplementation was associated with statistically significantly elevated risk of squamous cell carcinoma (HR = 1.25, 95% CI = 1.03 to 1.51) and of total nonmelanoma skin cancer (HR = 1.17, 95% CI = 1.02 to 1.34). Results from the Nutritional Prevention of Cancer Trial conducted among individuals at high risk of nonmelanoma skin cancer continue to demonstrate that selenium supplementation is ineffective at preventing basal cell carcinoma and that it increases the risk of squamous cell carcinoma and total nonmelanoma skin cancer.

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Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988
Negative binomial and mixed Poisson regression
Lawless, J. F. (1987) · Canadian Journal of Statistics · doi:10.2307/3314912 · Cited by 1,117
Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial
Green, A., Williams, G., Nèale, R., Hart, V., Leslie, D., Parsons, P., Marks, G. C., Gaffney, P., Battistutta, D., Frost, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12168-2 · Cited by 976
Prevention of Skin Cancer in Xeroderma Pigmentosum with the Use of Oral Isotretinoin
Kraemer, K. H., DiGiovanna, J. J., Moshell, A. N., Tarone, R. E., & Peck, G. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806233182501 · Cited by 574
Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial.
Duffield‐Lillico, A. J., Reid, M. E., Turnbull, B. W., Combs, G. F., Slate, E. H., Fischbach, L. A., Marshall, J. R., & Clark, L. C. (2002) · PubMed · Cited by 537
Self-citation
A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin
Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199009203231204 · Cited by 482
Prevention of skin cancer and reduction of keratotic skin lesions during acitretin therapy in renal transplant recipients: a double-blind, placebo-controlled study.
Bavinck, J. N. B., Tieben, L. M., van der Woude, F. J., TEGZESS, A. M., Hermans, J., ter Schegget, J., & Vermeer, B. J. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.8.1933 · Cited by 395
Antioxidant Nutrients and Pulmonary Function: The Third National Health and Nutrition Examination Survey (NHANES III)
Hu, G., & Cassano, P. A. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010141 · Cited by 260
SELECT: THE NEXT PROSTATE CANCER PREVENTION TRIAL
Klein, E. A., Thompson, I. M., Lippman, S. M., Goodman, P. J., Albanes, D., Taylor, P. R., & Coltman, C. A. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65759-x · Cited by 252
Activity of methylated forms of selenium in cancer prevention.
Ip, C., & Ganther, H. E. (1990) · PubMed · Cited by 209

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Schwabe, U., & Ziegler, R. (2007) · Springer eBooks · doi:10.1007/978-3-540-34370-7_37 · Cited by 11
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Brown, C. H., Baidas, S. M., Hajdenberg, J. J., Kayaleh, O. R., Pennock, G. K., Shah, N. C., & Tseng, J. E. (2009) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609334983 · Cited by 10
Selenium as a Cancer Preventive Agent
Jackson, M. I., & Combs, G. F. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1025-6_24 · Cited by 10
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Bedair, K., Hong, Y., Li, J., & Al‐Khalidi, H. R. (2016) · Computational Statistics & Data Analysis · doi:10.1016/j.csda.2016.01.018 · Cited by 9
Correlation of Some Trace Elements Serum Levels with Prostate Cancer Progression in Saudi Patients
Saleh, S. A. K., Adly, H. M., Abdulkhaliq, A. A., & Nassir, A. M. (2019) · The Open Public Health Journal · doi:10.2174/1874944501912010212 · Cited by 9
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Principles of Cancer Prevention
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Heart healthy equals prostate healthy and statins, aspirin, and/or metformin (S.A.M.) are the ideal recommendations for prostate cancer prevention
Moyad, M. A., & Vogelzang, N. J. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.148070 · Cited by 7
Bioavailability of selenium from the selenotrisulphide derivative of lipoic acid
Alonis, M. L., Pinnell, S. R., & Self, W. T. (2006) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2006.00257.x · Cited by 7
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Roussel, A.-M., & Hininger‐Favier, I. (2009) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(09)49501-5 · Cited by 7
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Lai, S. Y., & Weber, R. S. (2005) · Current Oncology Reports · doi:10.1007/s11912-005-0042-9 · Cited by 7
Nutritional epidemiological studies in cancer prevention
Fortes, C., & Boffetta, P. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3283481e07 · Cited by 6
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Self, W. T. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00692-4 · Cited by 6
Chemopreventive compounds in the diet.
Schreier, P. (2005) · Developments in ophthalmology · doi:10.1159/000082765 · Cited by 7
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Berra, B., & Rizzo, A. M. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-2029-0.50014-4 · Cited by 5

Authors: Duffield-Lillico, A. J.
Venue: CancerSpectrum Knowledge Environment
Publisher: Oxford University Press (OUP)
Published: 2003-10-01
Volume: 95
Issue: 19
Pages: 1477-1481
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/djg061
OpenAlex: W2158736644
Cited by: 301
References: 36
Citations by year: 2026: 4 · 2025: 7 · 2024: 5 · 2023: 13 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 15 · 2014: 15 · 2013: 16 · 2012: 22
FWCI: 15.44
Type: journal article
Language: en
Open access: closed
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca049764-15)
National Cancer Institute (R01 CA49764)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords: selenium supplementation, selenium yeast, non-melanoma skin cancer, basal cell carcinoma, squamous cell carcinoma, cancer prevention, high-risk patients, time to cancer diagnosis, multiple skin tumors
MeSH terms: Adult, Aged, Antineoplastic Agents, Carcinoma, Basal Cell, Basal Cell Carcinoma, Carcinoma, Squamous Cell, Double-Blind Method, Female, Humans, Male, Middle Aged, Risk Factors, Selenium, Skin Neoplasms, United States, Incidence, Odds Ratio, Treatment Failure, Dietary Supplements

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Selenium Supplementation and Secondary Prevention of Nonmelanoma Skin Cancer in a Randomized Trial

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