The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Selenium Supplementation and Secondary Prevention of Nonmelanoma Skin Cancer in a Randomized Trial
Abstract
The Nutritional Prevention of Cancer Trial was a double-blind, randomized, placebo-controlled clinical trial designed to test whether selenium as selenized yeast (200 microg daily) could prevent nonmelanoma skin cancer among 1312 patients from the Eastern United States who had previously had this disease. Results from September 15, 1983, through December 31, 1993, showed no association between treatment and the incidence of basal and squamous cell carcinomas of the skin. This report summarizes the entire blinded treatment period, which ended on January 31, 1996. The association between treatment and time to first nonmelanoma skin cancer diagnosis and between treatment and time to multiple skin tumors overall and within subgroups, defined by baseline characteristics, was evaluated. Although results through the entire blinded period continued to show that selenium supplementation was not statistically significantly associated with the risk of basal cell carcinoma (hazard ratio [HR] = 1.09, 95% confidence interval [CI] = 0.94 to 1.26), selenium supplementation was associated with statistically significantly elevated risk of squamous cell carcinoma (HR = 1.25, 95% CI = 1.03 to 1.51) and of total nonmelanoma skin cancer (HR = 1.17, 95% CI = 1.02 to 1.34). Results from the Nutritional Prevention of Cancer Trial conducted among individuals at high risk of nonmelanoma skin cancer continue to demonstrate that selenium supplementation is ineffective at preventing basal cell carcinoma and that it increases the risk of squamous cell carcinoma and total nonmelanoma skin cancer.
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“However, some researchers have demonstrated that supplementation with Se does not significantly affect the incidence of BCC or is ineffective in preventing it [95,96].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [96]
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Metadata
- Authors
- Duffield-Lillico, A. J.
- Venue
- CancerSpectrum Knowledge Environment
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10-01
- Volume
- 95
- Issue
- 19
- Pages
- 1477-1481
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2158736644
- Cited by
- 301
- References
- 36
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 13 · 2022: 11 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 15 · 2014: 15 · 2013: 16 · 2012: 22
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca049764-15)
- National Cancer Institute (R01 CA49764)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- selenium supplementation, selenium yeast, non-melanoma skin cancer, basal cell carcinoma, squamous cell carcinoma, cancer prevention, high-risk patients, time to cancer diagnosis, multiple skin tumors
- MeSH terms
- Adult, Aged, Antineoplastic Agents, Carcinoma, Basal Cell, Basal Cell Carcinoma, Carcinoma, Squamous Cell, Double-Blind Method, Female, Humans, Male, Middle Aged, Risk Factors, Selenium, Skin Neoplasms, United States, Incidence, Odds Ratio, Treatment Failure, Dietary Supplements
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