CoChat
Sign Up
Cited by 680Prostate Cancer Diagnosis and TreatmentCancer survivorship and careMultiple and Secondary Primary Cancers

Five-Year Outcomes After Prostatectomy or Radiotherapy for Prostate Cancer: The Prostate Cancer Outcomes Study

Potosky, A. L., Davis, W. W., Hoffman, R. M., Stanford, J. L., Stephenson, R. A., Penson, D. F., Harlan, L. C.·2004·JNCI Journal of the National Cancer Institute
DOI 10.1093/jnci/djh259
Open this paper in CoChat — free account

Abstract

BACKGROUND: Men treated for clinically localized prostate cancer with either radical prostatectomy or external beam radiotherapy usually survive many years with the side effects of these treatments. We present treatment-specific quality-of-life outcomes for prostate cancer patients 5 years after initial diagnosis. METHODS: The cohort consisted of men aged 55-74 years who were newly diagnosed with clinically localized prostate cancer in 1994-1995 and were treated with radical prostatectomy (n = 901) or external beam radiotherapy (n = 286). We used clinical and quality-of-life data previously collected at the time of diagnosis (i.e., baseline) and at the 2-year follow-up and data newly collected at 5 years after diagnosis to compare urinary, bowel, and sexual function and to examine temporal changes in those functions. Odds ratios (ORs) and adjusted percentages were calculated by logistic regression. All statistical tests were two-sided. RESULTS: At 5 years after diagnosis, overall sexual function declined in both groups to approximately the same level. However, at 5 years after diagnosis, erectile dysfunction was more prevalent in the radical prostatectomy group than in the external beam radiotherapy group (79.3% versus 63.5%; OR = 2.5, 95% confidence interval [CI] = 1.6 to 3.8). Approximately 14%-16% of radical prostatectomy and 4% of external beam radiotherapy patients were incontinent at 5 years (OR = 4.4, 95% CI = 2.2 to 8.6). Bowel urgency and painful hemorrhoids were more common in the external beam radiotherapy group than in the radical prostatectomy group. All of these differences remained statistically significant after adjustment for confounders and for differences between treatment groups in some baseline characteristics. CONCLUSIONS: At 5 years after diagnosis, men treated with radical prostatectomy for localized prostate cancer continue to experience worse urinary incontinence than men treated with external beam radiotherapy. However, the two treatment groups were more similar to each other with respect to overall sexual function, mostly because of a continuing decline in erectile function among the external beam radiotherapy patients between years 2 and 5.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/jnci/djh259

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • For early-stage prostate cancer, the main treatment options-radical prostatectomy, radiation therapy, and active surveillance-can produce different outcomes in sexual, urinary, or bowel function over time.

    “For early stage cancer, primary treatment options are radical prostatectomy, radiation therapy, and active surveillance, which can lead to differences in specific areas of functioning, such as sexual, urinary or bowel functioning over time [2, 3].”

    From Prostate cancer: Psychosocial implications and management (2008) · cites this paper as [3]

    The opening section lists prostatectomy, radiotherapy, and conservative management among the choices for clinically localized prostate cancer. The Discussion reports differences in urinary, bowel, and sexual function over five years after prostatectomy or external-beam radiotherapy. It does not identify active surveillance specifically or compare its functional outcomes with those treatments. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 42 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. [22]22. Fleming C, Wasson J, Albertsen PC, Barry MJ, Wennberg JE. A decision analysis of alternative treatment strategies for clinically localized prostate cancer. JAMA 1993;269:2650 -8.
  2. [30]30. Fransson P, Widmark A. Self-assessed sexual function after pelvic irradi- ation for prostate carcinoma. Comparison with an age-matched control group. Cancer 1996;78:1066 -78.
  3. [33]33. Demers RY, Tiwari A, Wei J, Weiss LK, Severson RK, Montie J. Trends in the utilization of androgen-deprivation therapy for patients with prostate carcinoma suggest an effect on mortality. Cancer 2001;92:2309 -17.

Cited by

Sorted by citations

Related

Authors
Potosky, A. L., Davis, W. W., Hoffman, R. M., Stanford, J. L., Stephenson, R. A., Penson, D. F., & Harlan, L. C.
Affiliations
University of Southern California (US)
Corresponding author
Potosky, A. L.
ORCID
Venue
JNCI Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
2004-09-14
Volume
96
Issue
18
Pages
1358-1367
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/djh259
OpenAlex
W2160612556
Cited by
680
References
42
Citations by year
2026: 15 · 2025: 8 · 2024: 16 · 2023: 15 · 2022: 12 · 2021: 15 · 2020: 19 · 2019: 18 · 2018: 26 · 2017: 30 · 2016: 28 · 2015: 32 · 2014: 47 · 2013: 54 · 2012: 55
FWCI
32.02
Type
journal article
Language
en
Open access
closed
Locations
  • JNCI Journal of the National Cancer Institute (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • National Institutes of Health (n01pc067010-004, n01pc067009-004, n01pc067000-000, n01pc067005-009, n01pc067007-017, N01-PC67010, n01pc067006-000)
  • National Cancer Institute (N01-PC-67010, N01-PC-67006, N01 PC-67009, N01 PC67000, N01-PC-67007, N01 PC 67005)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
Keywords
prostate cancer, radical prostatectomy, external beam radiotherapy, quality of life, erectile dysfunction, urinary incontinence, bowel function, sexual function, long-term treatment outcomes, localized prostate cancer
MeSH terms
Aged, Fecal Incontinence, Humans, Erectile Dysfunction, Male, Middle Aged, Prospective Studies, Prostatectomy, Prostatic Neoplasms, Quality of Life, Surveys and Questionnaires, Research Design, Socioeconomic Factors, Urinary Incontinence, Selection Bias, Logistic Models, Radiotherapy, Adjuvant

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review