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Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer
Open accessAbstract
BACKGROUND: Senescent cells, which express p16 (INK4a) , accumulate with aging and contribute to age-related pathology. To understand whether cytotoxic agents promote molecular aging, we measured expression of p16 (INK4a) and other senescence markers in breast cancer patients treated with adjuvant chemotherapy. METHODS: Blood and clinical information were prospectively obtained from 33 women with stage I to III breast cancer at four time points: before anthracycline-based chemotherapy, immediately after anthracycline-based chemotherapy, 3 months after anthracycline-based chemotherapy, and 12 months after anthracycline-based chemotherapy. Expression of senescence markers p16 (INK4a) and ARF mRNA was determined using TaqMan quantitative reverse-transcription polymerase chain reaction in CD3(+) T lymphocytes, telomere length was determined by Southern analysis, and senescence-associated cytokines were determined by enzyme-linked immunosorbent assay. Findings were independently assessed in a cross-sectional cohort of 176 breast cancer survivors enrolled a median of 3.4 years after treatment; 39% previously received chemotherapy. All statistical tests were two-sided. RESULTS: In prospectively analyzed patients, expression of p16 (INK4a) and ARF increased immediately after chemotherapy and remained elevated 12 months after treatment. Median increase in log2 p16 (INK4a) was 0.81 (interquartile range = 0.28-1.62; Wilcoxon signed-rank P < .001), or a 75% absolute increase in expression, equivalent to the increase observed over 14.7 years of chronological aging. ARF expression was comparably increased (P < .001). Increased expression of p16 (INK4a) and ARF was associated with dose-dense therapy and hematological toxicity. Expression of two senescence-associated cytokines (VEGFA and MCP1) was durably increased by adjuvant chemotherapy. Telomere length was not affected by chemotherapy. In a cross-sectional cohort, prior chemotherapy exposure was independently associated with a log2-increase in p16 (INK4a) expression of 0.57 (repeated measures model, P < .001), comparable with 10.4 years of chronological aging. CONCLUSIONS: Adjuvant chemotherapy for breast cancer is gerontogenic, inducing cellular senescence in vivo, thereby accelerating molecular aging of hematopoietic tissues.
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“the detection of an increased number of Tcells overexpressing p16 INK4a in patients with breast cancer treated with different chemotherapeutic agents is a finding worth highlighting because it indicates that immunosenescence can occur as a bystander effect of treatment 99,100 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [99]
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“to increase following chemotherapy;30”
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“Another study showed that cytotoxic chemotherapy increases cellular senescence (higher p16 INK4a expression) in the haematopoietic compartment in patients with breast cancer and induces long- lasting elevation of the SASP factors VEGFA and CCL2 (ref. 99 ) .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [99]
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“senescence markers have been detected in human breast cancer samples from patients treated with chemotherapy [343].”
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Citations
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
(2016) · Springer eBooks · doi:10.1007/978-3-319-40618-3 · Cited by 17,300
(2002) · Springer eBooks · doi:10.1007/978-1-4757-3656-4 · Cited by 6,375
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Cancer treatment and survivorship statistics, 2012
Siegel, R. L., Desantis, C. E., Virgo, K. S., Stein, K., Mariotto, A. B., Smith, T. G., Cooper, D. L., Gansler, T. S., Lerro, C. C., Fedewa, S. A., et al. (2012) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21149 · Cited by 2,979
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2012) · The Lancet · doi:10.1016/s0140-6736(11)61625-5 · Cited by 2,091
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,070 · cited 1×
“This loss of function is characterized by a decline in the replicative capacity of certain self-renewing cells and the accumulation of cells that have undergone cellular senescence (10,11).”
BackgroundFuture of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation
Smith, B. D., Smith, G. L., Hurria, A., Hortobágyi, G. N., & Buchholz, T. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.8983 · Cited by 1,733
Self-citationCitron, M. L., Berry, D. A., Cirrincione, C., Hudis, C. A., Winer, E. P., Gradishar, W. J., Davidson, N. E., Martino, S., Livingston, R. B., Ingle, J. N., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.09.081 · Cited by 1,564
Self-citation
Cited by
Sorted by citations
Senescence in Health and Disease
He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766
Self-citationCellular senescence promotes adverse effects of chemotherapy and cancer relapse
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338
Self-citationForging a signature of in vivo senescence
Sharpless, N. E., & Sherr, C. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3960 · Cited by 1,104
Self-citationHow the ageing microenvironment influences tumour progression
Fane, M., & Weeraratna, A. T. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0222-9 · Cited by 849
Senescence and cancer — role and therapeutic opportunities
Schmitt, C. A., Wang, B., & Demaria, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00668-4 · Cited by 794
Zafar, A., Khatoon, S., Khan, M. J., Abu, J., & Naeem, A. (2025) · Discover Oncology · doi:10.1007/s12672-025-02198-8 · Cited by 676
Wefel, J. S., Kesler, S. R., Noll, K. R., & Schagen, S. B. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21258 · Cited by 546
Senescent Cells in Cancer Therapy: Friends or Foes?
Wang, B., Kohli, J., & Demaria, M. (2020) · Trends in Cancer · doi:10.1016/j.trecan.2020.05.004 · Cited by 508
Masaldan, S., Clatworthy, S. A. S., Gamell, C., Meggyesy, P. M., Rigopoulos, A.-T., Haupt, S., Haupt, Y., Denoyer, D., Adlard, P. A., Bush, A. I., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2017.08.015 · Cited by 452
Mechanisms and Regulation of Cellular Senescence
Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395
DNA damage-how and why we age?
Yousefzadeh, M., Henpita, C., Vyas, R., Soto-Palma, C., Robbins, P., & Niedernhofer, L. (2021) · eLife · doi:10.7554/elife.62852 · Cited by 399
Cancer progression and the invisible phase of metastatic colonization
Klein, C. A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00300-6 · Cited by 387
Cognitive Effects of Cancer and Cancer Treatments
Ahles, T. A., & Root, J. C. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050817-084903 · Cited by 416
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Prasanna, P. G. S., Citrin, D. E., Hildesheim, J., Ahmed, M. M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., van Deursen, J., Goronzy, J. J., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab064 · Cited by 359
Self-citationExercise therapy and cardiovascular toxicity in cancer
Scott, J. M., Nilsen, T. S., Gupta, D., & Jones, L. W. (2018) · Circulation · doi:10.1161/circulationaha.117.024671 · Cited by 239
Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors
Guida, J. L., Ahles, T. A., Belsky, D., Campisi, J., Cohen, H. J., DeGregori, J., Fuldner, R., Ferrucci, L., Gallicchio, L., Gavrilov, L., et al. (2019) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djz136 · Cited by 216
Self-citationBower, J. E. (2019) · Cancer · doi:10.1002/cncr.31790 · Cited by 219
Cellular senescence in cancer: from mechanisms to detection
Ou, H., Hoffmann, R. J., González‐López, C., Doherty, G. J., Korkola, J. E., & Muñoz‐Espín, D. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12807 · Cited by 208
Mandelblatt, J. S., Small, B. J., Luta, G., Hurria, A., Jim, H., McDonald, B. C., Graham, D. M. A., Zhou, X., Clapp, J. D., Zhai, W., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.18.00140 · Cited by 188
Self-citationKesler, S. R., & Blayney, D. W. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.4333 · Cited by 176
Senescent T cells: a potential biomarker and target for cancer therapy
Zhang, J., He, T., Xue, L., & Guo, H. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103409 · Cited by 175
Muñoz, D. P., Yannone, S. M., Daemen, A., Sun, Y., Vakar-Lopez, F., Kawahara, M., Freund, A. M., Rodier, F., Wu, J. D., Desprez, P.-Y., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124716 · Cited by 162
The role of epigenetic modifications in drug resistance and treatment of breast cancer
Fath, M. K., Azargoonjahromi, A., Kiani, A., Jalalifar, F., Osati, P., Oryani, M. A., Shakeri, F., Nasirzadeh, F., Khalesi, B., Nabi‐Afjadi, M., et al. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00344-6 · Cited by 153
Senescence and the tumor-immune landscape: Implications for cancer immunotherapy
Chibaya, L., Snyder, J. T., & Ruscetti, M. A. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.005 · Cited by 146
Hodes, R. J., Sierra, F., Austad, S. N., Epel, E., Neigh, G. N., Erlandson, K. M., Schafer, M. J., LeBrasseur, N. K., Wiley, C., Campisi, J., et al. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13299 · Cited by 132
Self-citationCancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions
Hurria, A., Jones, L. W., & Muss, H. B. (2016) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_156160 · Cited by 143
Self-citationFrailty and aging in cancer survivors
Ness, K. K., & Wogksch, M. D. (2020) · Translational Research · doi:10.1016/j.trsl.2020.03.013 · Cited by 124
Farr, J. N., Atkinson, E. J., Achenbach, S. J., Volkman, T. L., Tweed, A. J., Vos, S. J., Ruan, M., Sfeir, J., Drake, M. T., Saul, D., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03096-2 · Cited by 127
“…to increase with age 20 , physical inactivity 20 and smoking 20 ; to be associated with plasma interleukin-6 (IL-6) levels (a marker of human frailty) 20 ; to increase following chemotherapy; 30 and to predict length of hospital stay after coronary artery bypass surgery in older adults 31 .”
Bagnall-Moreau, C., Chaudhry, S., Salas-Ramirez, K. Y., Ahles, T. A., & Hubbard, K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1589-z · Cited by 118
Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment
Wang, S., Prizment, A. E., Thyagarajan, B., & Blaes, A. H. (2021) · Cancers · doi:10.3390/cancers13030427 · Cited by 118
Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment
Maggiorani, D., Lê, O., Lisi, V., Landais, S., Moquin‐Beaudry, G., Lavallée, V., Decaluwe, H., & Beausejour, C. M. (2024) · Nature Communications · doi:10.1038/s41467-024-46769-9 · Cited by 130
Ahles, T. A., & Hurria, A. (2017) · Psycho-Oncology · doi:10.1002/pon.4564 · Cited by 114
Self-citationJustice, J., Miller, J. D., Newman, J. C., Hashmi, S. K., Halter, J., Austad, S. N., Barzilai, N., & Kirkland, J. L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw126 · Cited by 96
Nyrop, K. A., Deal, A. M., Reeder‐Hayes, K. E., Shachar, S. S., Reeve, B. B., Basch, E., Choi, S. K., Lee, J. T., Wood, W. A., Anders, C. K., et al. (2019) · Cancer · doi:10.1002/cncr.32175 · Cited by 95
Self-citationMoruno-Manchon, J. F., Koellhoffer, E. C., Gopakumar, J., Hambarde, S., Kim, N., McCullough, L. D., & Tsvetkov, A. S. (2017) · Aging · doi:10.18632/aging.101282 · Cited by 88
Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer
Kesler, S. R., Watson, C., & Blayney, D. W. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.015 · Cited by 94
Kanesvaran, R., Córdoba, R., & Maggiore, R. J. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_201435 · Cited by 92
Salas-Ramirez, K. Y., Bagnall, C., Frias, L., Abdali, S. A., Ahles, T. A., & Hubbard, K. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.028 · Cited by 88
Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study
Mandelblatt, J. S., Zhai, W., Ahn, J., Small, B. J., Ahles, T. A., Carroll, J., Denduluri, N., Dilawari, A. A., Extermann, M., Graham, D. M. A., et al. (2019) · Cancer · doi:10.1002/cncr.32663 · Cited by 84
Self-citationBreast cancer treatment and its effects on aging
Chang, L., Weiner, L. S., Hartman, S. J., Horvath, S., Jeste, D. V., Mischel, P. S., & Kado, D. M. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.07.010 · Cited by 84
Smitherman, A. B., Wood, W. A., Mitin, N., Ayer Miller, V. L., Deal, A. M., Davis, I. J., Blatt, J., Gold, S. H., & Muss, H. B. (2020) · Cancer · doi:10.1002/cncr.33112 · Cited by 80
Self-citationCarroll, J., Bower, J. E., & Ganz, P. A. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00580-3 · Cited by 81
Sehl, M. E., Carroll, J., Horvath, S., & Bower, J. E. (2020) · npj Breast Cancer · doi:10.1038/s41523-020-0161-3 · Cited by 76
Telomere Length and Breast Cancer Prognosis: A Systematic Review
Ennour‐Idrissi, K., Maunsell, E., & Diorio, C. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0343 · Cited by 75
Cognitive performance in survivors of breast cancer and markers of biological aging
Carroll, J., Dyk, K. V., Bower, J. E., Scuric, Z., Petersen, L., Schiestl, R. H., Irwin, M. R., & Ganz, P. A. (2018) · Cancer · doi:10.1002/cncr.31777 · Cited by 78
The senescence journey in cancer immunoediting
Zingoni, A., Antonangeli, F., Sozzani, S., Santoni, A., Cippitelli, M., & Soriani, A. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01973-5 · Cited by 77
p16 a biomarker of aging and tolerance for cancer therapy
Muss, H. B., Smitherman, A. B., Wood, W. A., Nyrop, K. A., Tuchman, S. A., Randhawa, P. K., Entwistle, A., Mitin, N., & Shachar, S. S. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.03.39 · Cited by 71
Self-citationOwusu, C., & Berger, N. A. (2014) · Clinical Practice · doi:10.2217/cpr.14.72 · Cited by 70
Wu, Y., Deng, Z., Wang, H., Ma, W., Zhou, C., & Zhang, S. (2016) · BMC Immunology · doi:10.1186/s12865-016-0167-7 · Cited by 69
Wood, W. A., Krishnamurthy, J., Mitin, N., Torrice, C., Parker, J. S., Snavely, A. C., Shea, T. C., Serody, J. S., & Sharpless, N. E. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.029 · Cited by 73
Self-citationDefining the toxicology of aging
Sorrentino, J. A., Sanoff, H. K., & Sharpless, N. E. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.04.004 · Cited by 69
Self-citationTurner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 66
Biomarkers of aging associated with past treatments in breast cancer survivors
Scuric, Z., Carroll, J., Bower, J. E., Ramos-Perlberg, S., Petersen, L., Esquivel, S., Hogan, M., Chapman, A. M., Irwin, M. R., Breen, E. C., et al. (2017) · npj Breast Cancer · doi:10.1038/s41523-017-0050-6 · Cited by 66
Cognitive Function in Older Adults With Cancer: Assessment, Management, and Research Opportunities
Magnuson, A. M., Ahles, T. A., Chen, B. T., Mandelblatt, J. S., & Janelsins, M. C. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.00239 · Cited by 62
Mandelblatt, J. S., Zhou, X., Small, B. J., Ahn, J., Zhai, W., Ahles, T. A., Extermann, M., Graham, D. M. A., Jacobsen, P. B., Jim, H., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab003 · Cited by 57
Sleight, A. G., Crowder, S. L., Skarbinski, J., Coen, P. M., Parker, N. H., Hoogland, A. I., Gonzalez, B. D., Playdon, M. C., Cole, S. W., Ose, J., et al. (2022) · Cancers · doi:10.3390/cancers14081982 · Cited by 63
TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin
Moruno-Manchon, J. F., Uzor, N.-E., Kesler, S. R., Wefel, J. S., Townley, D. M., Nagaraja, A. S., Pradeep, S., Mangala, L. S., Sood, A. K., & Tsvetkov, A. S. (2016) · Aging · doi:10.18632/aging.101144 · Cited by 61
Chakrabarty, A., Chakraborty, S., Bhattacharya, R., & Chowdhury, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.674354 · Cited by 59
Brouwers, B. A. H., Hatse, S., Lago, L. D., Neven, P., Vuylsteke, P., Dalmasso, B., Debrock, G., den Bulck, H. V., Smeets, A., Bechter, O. E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8796 · Cited by 56
Xiong, J., Dong, L., Lv, Q., Yin, Y., Zhao, J., Ke, Y., Wang, S., Zhang, W., & Wu, M. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1772 · Cited by 58
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment
Palacio, L., Goyer, M., Maggiorani, D., Espinosa, A., Villeneuve, N., Bourbonnais, S., Moquin‐Beaudry, G., Le, O., Demaria, M., Davalos, A. R., et al. (2019) · Aging Cell · doi:10.1111/acel.12971 · Cited by 54
Mandelblatt, J. S., Ahles, T. A., Lippman, M. E., Isaacs, C. J., Adams-Campbell, L. L., Saykin, A. J., Cohen, H. J., & Carroll, J. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.1160 · Cited by 53
Cellular senescence and other age-related mechanisms in skeletal diseases
Li, K., Hu, S., & Chen, H. (2025) · Bone Research · doi:10.1038/s41413-025-00448-7 · Cited by 58
The 2014–2018 Oncology Nursing Society Research Agenda
Knobf, M. T., Cooley, M. E., Duffy, S. A., Doorenbos, A. Z., Eaton, L. H., Given, B. A., Mayer, D. K., McCorkle, R. C., Miaskowski, C. A., Mitchell, S. A., et al. (2015) · Oncology nursing forum · doi:10.1188/15.onf.450-465 · Cited by 55
Guan, L., Crasta, K., & Maier, A. B. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101634 · Cited by 54
The Independent Effects of Strength Training in Cancer Survivors: a Systematic Review
Hanson, E. D., Wagoner, C. W., Anderson, T., & Battaglini, C. L. (2016) · Current Oncology Reports · doi:10.1007/s11912-016-0511-3 · Cited by 57
Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy
Moruno-Manchon, J. F., Uzor, N.-E., Kesler, S. R., Wefel, J. S., Townley, D. M., Nagaraja, A. S., Pradeep, S., Mangala, L. S., Sood, A. K., & Tsvetkov, A. S. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.11.014 · Cited by 54
Knight, J. M., Rizzo, J. D., Hari, P., Pasquini, M. C., Giles, K. E., D’Souza, A., Logan, B. R., Hamadani, M., Chhabra, S., Dhakal, B., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000765 · Cited by 53
Ming, X., Yang, Z. R., Huang, Y., Wang, Z., Zhang, Q., Lu, C., Sun, Y., Chen, Y., Zhang, L., Wu, J., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00750-9 · Cited by 57
The Effect of Cancer Treatments on Telomere Length: A Systematic Review of the Literature
Gallicchio, L. M., Gadalla, S. M., Murphy, J. D., & Simonds, N. I. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy189 · Cited by 51
The senescence-associated secretory phenotype: Fueling a wound that never heals
Pulido, T., Velarde, M. C., & Alimirah, F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111561 · Cited by 54
Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions
Vallet‐Regí, M., Manzano, M., Rodríguez‐Mañas, L., Checa‐López, M., Aapro, M., & Balducci, L. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0276 · Cited by 50
Nicotinamide mononucleotide prevents cisplatin-induced cognitive impairments
Yoo, K., Tang, J. J., Rashid, M., Chang, H.-C., Corujo-Ramirez, A., Choi, J., Bae, M. G., Brogren, D., Hawse, J., Hou, X., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3290 · Cited by 38
Kato, S., Schwaederle, M. C., Daniels, G. A., Piccioni, D. E., Kesari, S., Bazhenova, L. A., Shimabukuro, K. A., Parker, B. A., Fanta, P. T., & Kurzrock, R. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1014149 · Cited by 49
The prevalence of frailty among breast cancer patients: a systematic review and meta-analysis
Wang, S., Yang, T., Qiang, W., Shen, A., Zhao, Z., Yang, H., & Liu, X. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06641-8 · Cited by 50
Kesler, S. R., Rao, V., Ray, W. J., Rao, A. U. K., & Initiative, A. D. N. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.10.002 · Cited by 48
Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence
Abdelgawad, I. Y., Sadak, K. T., Lone, D. W., Dabour, M. S., Niedernhofer, L. J., & Zordoky, B. N. M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107751 · Cited by 47
Mouse Models of Accelerated Cellular Senescence
Yousefzadeh, M. J., Melos, K. I., Angelini, L. A., Burd, C. E., Robbins, P. D., & Niedernhofer, L. J. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8931-7_17 · Cited by 48
Rentscher, K. E., Bethea, T. N., Zhai, W., Small, B. J., Zhou, X., Ahles, T. A., Ahn, J., Breen, E. C., Cohen, H. J., Extermann, M., et al. (2023) · Cancer · doi:10.1002/cncr.34818 · Cited by 49
Li, D., de Glas, N. A., & Hurria, A. (2015) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2015.08.003 · Cited by 44
Self-citationFeng, M., Kim, J., Field, K. P., Reid, C., Chatzistamou, I., & Shim, M. (2019) · FASEB BioAdvances · doi:10.1096/fba.2019-00041 · Cited by 44
Relationship between cognitive functioning and frailty in older breast cancer survivors
Ahles, T. A., Schofield, E., Li, Y., Ryan, E., Root, J. C., Patel, S. K., McNeal, K., Gaynor, A. M., Tan, H., Katheria, V., et al. (2021) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2021.07.011 · Cited by 43
Self-citationActivatable senoprobes and senolytics: Novel strategies to detect and target senescent cells
Morsli, S., Doherty, G. J., & Muñoz‐Espín, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111618 · Cited by 41
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Shafqat, S., Arana‐Chicas, E., Shafqat, A., & Hashmi, S. K. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158452 · Cited by 43
Rosko, A. E., Hofmeister, C. C., Benson, D. M., Efebera, Y. A., Huang, Y., Gillahan, J. E., Byrd, J. C., & Burd, C. E. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2015.143 · Cited by 40
Optimal management of breast cancer in the elderly patient: current perspectives
Falandry, C., Saux, O. L., Freyer, G., Bonnefoy, M., Ripamonti, B., Bonin, O., & Bruyas, A. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s50670 · Cited by 40
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Bhatia, R., Holtan, S. G., Jurdi, N. E., Prizment, A. E., & Blaes, A. H. (2022) · Current Oncology Reports · doi:10.1007/s11912-022-01311-2 · Cited by 41
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Onyema, O. O., Decoster, L., Njemini, R., Forti, L. N., Bautmans, I., Waele, M. D., & Mets, T. F. (2015) · BMC Cancer · doi:10.1186/s12885-015-2013-3 · Cited by 38
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Henneghan, A. M., Rao, V., Harrison, R. A., Karuturi, M. S., Blayney, D. W., Palesh, O. G., & Kesler, S. R. (2020) · Neurotoxicity Research · doi:10.1007/s12640-019-00158-z · Cited by 38
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Jones, L. M., Stoner, L. R., Baldi, J. C., & McLaren, B. R. (2020) · European Journal of Cancer Care · doi:10.1111/ecc.13231 · Cited by 37
Sase, K., Kida, K., & Furukawa, Y. (2020) · Journal of Cardiology · doi:10.1016/j.jjcc.2020.07.014 · Cited by 39
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Wang, H., Karuppan, M. K. M., Devadoss, D., Nair, M., Chand, H. S., & Lakshmana, M. K. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.06.003 · Cited by 35
Kotla, S., Zhang, A., Imanishi, M., Ko, K. A., Lin, S. H., Gi, Y. J., Moczygemba, M. M., Isgandarova, S., Schadler, K., Chung, C. D., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102132 · Cited by 36
Speidell, A. P., Demby, T. C., Lee, Y., Rodriguez, O. C., Albanese, C., Mandelblatt, J. S., & Rebeck, G. W. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9954-7 · Cited by 36
López-Jiménez, F. A., Kapa, S., Friedman, P. A., LeBrasseur, N. K., Klavetter, E. W., Mangold, K. E., & Attia, Z. I. (2024) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2024.02.011 · Cited by 37
Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients
Benitéz‐Buelga, C., Sánchez, L. M. M., Gallardo, M., Apellániz-Ruiz, M., Inglada‐Pérez, L., Yanowsky, K., Carrillo, J., García‐Estévez, L., Calvo, I., Perona, R., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3246-6 · Cited by 34
Kohanski, R. A., Deeks, S. G., Gravekamp, C., Halter, J. B., High, K. P., Hurria, A., Fuldner, R., Green, P. A., Huebner, R. E., Macchiarini, F., et al. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13297 · Cited by 34
Self-citationYuan, Y., Vora, N. L., Sun, C., Li, D., Soto‐Pérez‐de‐Celis, E., Mortimer, J. E., Luu, T. H., Somlo, G., Waisman, J. R., Smith, D. D., et al. (2017) · Breast Cancer Research · doi:10.1186/s13058-017-0895-5 · Cited by 34
Self-citation
Metadata
- Authors
- Sanoff, H. K., Deal, A. M., Krishnamurthy, J., Torrice, C., Dillon, P., Sorrentino, J., Ibrahim, J. G., Jolly, T. A., Williams, G., Carey, L. A., Drobish, A., Gordon, B.-B., Alston, S., Hurria, A., Kleinhans, K., Rudolph, K. L., Sharpless, N. E., & Muss, H. B.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-03-28
- Volume
- 106
- Issue
- 4
- Pages
- dju057-dju057
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- PMC
- PMC3982894
- OpenAlex
- W2126729859
- Cited by
- 283
- References
- 54
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 26 · 2023: 24 · 2022: 35 · 2021: 34 · 2020: 31 · 2019: 15 · 2018: 20 · 2017: 17 · 2016: 19 · 2015: 18 · 2014: 8
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Breast Cancer Research Foundation
- Glenn Foundation for Medical Research
- National Institutes of Health (2k12ca120780-16, 5r01ag024379-15, AG024379)
- National Institute on Aging (AG024379)
- National Cancer Institute (K12-CA120780, K07CA106722, P50CA058223, P30CA016086)
- National Institute of Environmental Health Sciences (P30ES010126, T32ES007126)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- breast cancer, cytotoxic chemotherapy, molecular aging, cellular senescence, p16INK4a, ARF, anthracycline chemotherapy, adjuvant chemotherapy, dose-dense chemotherapy, hematologic toxicity, VEGF-A, MCP-1, telomere length, T cells, hematopoietic tissue
- MeSH terms
- Adult, Aged, Animals, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cross-Sectional Studies, Female, Humans, Middle Aged, Neoplasm Staging, Prospective Studies, T-Lymphocytes, Biomarkers, Cytokines, Telomere, Cellular Senescence, Anthracyclines, Cyclin-Dependent Kinase Inhibitor p16, Reverse Transcriptase Polymerase Chain Reaction, ADP-Ribosylation Factors, Mice
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