How the ageing microenvironment influences tumour progression
Open accessAbstract
Most cancers arise in individuals over the age of 60. As the world population is living longer and reaching older ages, cancer is becoming a substantial public health problem. It is estimated that, by 2050, more than 20% of the world's population will be over the age of 60 - the economic, healthcare and financial burdens this may place on society are far from trivial. In this Review, we address the role of the ageing microenvironment in the promotion of tumour progression. Specifically, we discuss the cellular and molecular changes in non-cancerous cells during ageing, and how these may contribute towards a tumour permissive microenvironment; these changes encompass biophysical alterations in the extracellular matrix, changes in secreted factors and changes in the immune system. We also discuss the contribution of these changes to responses to cancer therapy as ageing predicts outcomes of therapy, including survival. Yet, in preclinical studies, the contribution of the aged microenvironment to therapy response is largely ignored, with most studies designed in 8-week-old mice rather than older mice that reflect an age appropriate to the disease being modelled. This may explain, in part, the failure of many successful preclinical therapies upon their translation to the clinic. Overall, the intention of this Review is to provide an overview of the interplay that occurs between ageing cell types in the microenvironment and cancer cells and how this is likely to impact tumour metastasis and therapy response.
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Age-related cellular senescence contributes to cancer development and progression.
“In addition to the accumulation of genomic mutations over time, age-related cellular senescence also contributes to cancer development and progression (2).”
From Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment (2023) · cites this paper as [2]
SASP has been linked to the aggressiveness of certain cancers.
“SASP has been linked to the aggressiveness of certain cancers (2, 10).”
From Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment (2023) · cites this paper as [2]
The tumor microenvironment may accelerate senescence of the immune system.
“However, the main obstacle to achieving efficacious immunotherapy is the tumor microenvironment (TME), which may accelerate senescence of the immune system [18, 19]: potential targets for rejuvenating the immune system are still a hypothesis.”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [18]
In the aging TME, changes in immune cell function and secretion of SASP molecules dramatically affect tumor progression.
“Furthermore, in aging TME, changes in immune cell function and secretion of SASP molecules dramatically affect tumor progression [18].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [18]
Emerging evidence suggests the aging microenvironment largely contributes to age-related decline in immune function and may also provide potential targets for rejuvenating the immune system.
“Finally, emerging evidence suggests that the aging microenvironment largely contributes to age-related decline in immune function and may also provide potential targets for rejuvenating the immune system [18].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [18]
The weakening of immunosurveillance by aging-associated chronic inflammation is in part due to biophysical alterations of the extracellular matrix that affect the mobility and placement of immune effectors.
“as well as due to biophysical alterations of the extracellular matrix that affect the mobility and placement of immune effectors.261”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [261]
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1 retracted
Kaur, A., Webster, M. R., Marchbank, K., Behera, R., Ndoye, A., Kugel, C. H., Dang, V. M., Appleton, J., O’Connell, M. P., Cheng, P., et al. (2016) · Nature · doi:10.1038/nature17392 · Cited by 398 · see citing works
Self-citationRetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21442 · Cited by 16,632 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma, P., Hu-Lieskovan, S., Wargo, J. A., & Ribas, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.017 · Cited by 5,588 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Cancer drug resistance: an evolving paradigm
Holohan, C., Van Schaeybroeck, S., Longley, D. B., & Johnston, P. G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3599 · Cited by 4,681 · see citing works
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246 · see citing works
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · see citing works
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works
The extracellular matrix modulates the hallmarks of cancer
Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,014 · see citing works
Mechanisms of photoaging and chronological skin aging
Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., & Voorhees, J. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1462 · Cited by 1,849 · see citing works
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works
Senescence in Health and Disease
He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works
Myeloid-derived suppressor cells coming of age
Veglia, F., Perego, M., & Gabrilovich, D. I. (2018) · Nature Immunology · doi:10.1038/s41590-017-0022-x · Cited by 1,766 · see citing works
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works
Increased bone formation in osteocalcin-deficient mice
Ducy, P. F., Morris, C., Boyce, B. F., Pinero, G. J., Story, B. M., Dunstan, C. R., Smith, E. A., Bonadio, J. F., Goldstein, S. A., Gundberg, C. M., et al. (1996) · Nature · doi:10.1038/382448a0 · Cited by 1,724 · see citing works
Men and mice: Relating their ages
Dutta, S., & Sengupta, P. (2016) · Life Sciences · doi:10.1016/j.lfs.2015.10.025 · Cited by 1,710 · see citing works
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
Gialeli, C., Theocharis, A. D., & Karamanos, N. K. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07919.x · Cited by 1,611 · see citing works
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569 · see citing works
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,558 · see citing works
Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works
Jeon, O. H., Kim, C., Laberge, R.-M., Demaria, M., Rathod, S., Vasserot, A. P., Chung, J. W., Kim, D. H., Poon, Y., David, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4324 · Cited by 1,515 · see citing works
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., Witkowski, J. M., & Franceschi, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01960 · Cited by 1,364 · see citing works
Naba, A., Clauser, K. R., Hoersch, S., Liu, H., Carr, S. A., & Hynes, R. O. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014647 · Cited by 1,354 · see citing works
Cellular senescence promotes adverse effects of chemotherapy and cancer relapse
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works
Cellular Senescence: Aging, Cancer, and Injury
Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019) · Physiological Reviews · doi:10.1152/physrev.00020.2018 · Cited by 1,270 · see citing works
L1 drives IFN in senescent cells and promotes age-associated inflammation
De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255 · see citing works
Senescence and aging: Causes, consequences, and therapeutic avenues
McHugh, D., & Gil, J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201708092 · Cited by 1,233 · see citing works
Targeting Tumor Microenvironment for Cancer Therapy
Roma-Rodrigues, C., Mendes, R., Baptista, P. V., & Fernandes, A. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040840 · Cited by 1,187 · see citing works
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186 · see citing works
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P. F., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,121 · see citing works
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Hernández, A. E. D. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,103 · see citing works
Tanaka, M., Yamamoto, Y., Misawa, E., Nabeshima, K., Saito, M., Yamauchi, K., Abe, F., & Furukawa, F. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000454718 · Cited by 1,092 · see citing works
Acerbi, I., Cassereau, L., Dean, I. S., Shi, Q., Au, A., Park, C., Chen, Y. Y., Liphardt, J., Hwang, E. S., & Weaver, V. M. (2015) · Integrative Biology · doi:10.1039/c5ib00040h · Cited by 1,062 · see citing works
Decreased Collagen Production in Chronologically Aged Skin
Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E. G., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051302 · Cited by 910 · see citing works
Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M., & Green, M. R. (2008) · Cell · doi:10.1016/j.cell.2007.12.032 · Cited by 903 · see citing works
Environment-mediated drug resistance: A major contributor to minimal residual disease
Meads, M. B., Gatenby, R. A., & Dalton, W. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2714 · Cited by 892 · see citing works
Unmasking senescence: context-dependent effects of SASP in cancer
Faget, D. V., Ren, Q., & Stewart, S. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0156-2 · Cited by 863 · see citing works
Cellular senescence and its effector programs
Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855 · see citing works
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
Shojaei, F., Wu, X., Malik, A. K., Zhong, C., Baldwin, M. E., Schanz, S., Fuh, G., Gerber, H.-P., & Ferrara, N. (2007) · Nature Biotechnology · doi:10.1038/nbt1323 · Cited by 849 · see citing works
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
Tian, X., Azpurua, J., Hine, C., Vaidya, A. M., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V. A., & Seluanov, A. (2013) · Nature · doi:10.1038/nature12234 · Cited by 786 · see citing works
Sethi, T., Rintoul, R. C., Moore, S. M., MacKinnon, A. C., Salter, D. M., Choo, C., Chilvers, E. R., Dransfield, I., Donnelly, S. C., Strieter, R. M., et al. (1999) · Nature Medicine · doi:10.1038/9511 · Cited by 739 · see citing works
Tumor-associated neutrophils: friend or foe?
Fridlender, Z. G., & Albelda, S. Μ. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs123 · Cited by 699 · see citing works
Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway
Maggio, M. G., Guralnik, J. M., Longo, D. L., & Ferrucci, L. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.575 · Cited by 687 · see citing works
Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637 · see citing works
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works
The organizing principle: microenvironmental influences in the normal and malignant breast
Bissell, M. J., Radisky, D. C., Rizki, A., Weaver, V. M., & PETERSEN, O. W. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.700907.x · Cited by 602 · see citing works
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science · doi:10.1126/science.aaf4445 · Cited by 589 · see citing works
The dynamic nature of senescence in cancer
Lee, S., & Schmitt, C. A. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0249-2 · Cited by 588 · see citing works
TAMeless traitors: macrophages in cancer progression and metastasis
Aras, S., & Zaidi, M. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.356 · Cited by 550 · see citing works
Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women
Liu, P.-H., Wu, K., Ng, K., Zauber, A. G., Nguyen, L. H., Song, M., He, X., Fuchs, C. S., Ogino, S., Willett, W. C., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2018.4280 · Cited by 514 · see citing works
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0381-y · Cited by 513 · see citing works
Liu, D., & Hornsby, P. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3452 · Cited by 499 · see citing works
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
Ruhland, M. K., Loza, A. J., Capietto, A.-H., Luo, X., Knolhoff, B. L., Flanagan, K. C., Belt, B. A., Alspach, E., Leahy, K., Luo, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11762 · Cited by 496 · see citing works
The Effect of Age on Thymic Function
Palmer, D. B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00316 · Cited by 494 · see citing works
Yager, E. J., Ahmed, M., Lanzer, K., Randall, T. D., Woodland, D. L., & Blackman, M. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071140 · Cited by 490 · see citing works
Aging-related inflammation in osteoarthritis
Greene, M. A., & Loeser, R. F. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.01.008 · Cited by 487 · see citing works
Burgstaller, G., Oehrle, B., Gerckens, M., White, E. S., Schiller, H. B., & Eickelberg, O. (2017) · European Respiratory Journal · doi:10.1183/13993003.01805-2016 · Cited by 483 · see citing works
Subtype-Dependent Relationship Between Young Age at Diagnosis and Breast Cancer Survival
Partridge, A. H., Hughes, M. E., Warner, E. T., Ottesen, R. A., Wong, Y., Edge, S. B., Theriault, R. L., Blayney, D. W., Niland, J. C., Winer, E. P., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.65.8013 · Cited by 478 · see citing works
Shojaei, F., Wu, X., Qu, X., Kowanetz, M., Yu, L., Tan, M., Meng, Y. G., & Ferrara, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902280106 · Cited by 473 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Krtolica, A., Beauséjour, C. M., Parrinello, S., Hodgson, J. G., Chin, K., Desprez, P.-Y., & Campisi, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009188 · Cited by 455 · see citing works
Bavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1716 · Cited by 453 · see citing works
Kaur, A., Ecker, B. L., Douglass, S. M., Kugel, C. H., Webster, M. R., Almeida, F. V., Somasundaram, R., Hayden, J. E., Ban, E., Ahmadzadeh, H., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0193 · Cited by 421 · see citing works
Self-citationSenescence-associated inflammatory responses: aging and cancer perspectives
Lasry, A., & Ben-Neriah, Y. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.009 · Cited by 408 · see citing works
Autophagy in cancer associated fibroblasts promotes tumor cell survival
Martinez‐Outschoorn, U., Trimmer, C., Zhao, L., Whitaker‐Menezes, D., Chiavarina, B., Zhou, J., Wang, C., Pavlides, S., Cantarin, M. P. M., Capozza, F., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12928 · Cited by 406 · see citing works
Significance of interleukin-6 (IL-6) in breast cancer (review)
Knüpfer, H., & Preiß, R. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9328-3 · Cited by 397 · see citing works
Il-23 secreted by myeloid cells drives castration-resistant prostate cancer
Calcinotto, A., Spataro, C., Zagato, E., Di Mitri, D., Gil, V., Crespo, M., De Bernardis, G., Losa, M., Mirenda, M., Pasquini, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0266-0 · Cited by 394 · see citing works
Poltavets, V., Kochetkova, M., Pitson, S. M., & Samuel, M. S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00431 · Cited by 377 · see citing works
The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
Aunan, J. R., Cho, W. C. S., & Søreide, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0103 · Cited by 373 · see citing works
Saule, P., Trauet, J., Dutriez, V., Lekeux, V., Dessaint, J., & Labalette, M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.001 · Cited by 369 · see citing works
Kugel, C. H., Douglass, S. M., Webster, M. R., Kaur, A., Liu, Q., Yin, X., Weiss, S. A., Darvishian, F., Al-Rohil, R. N., Ndoye, A., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1116 · Cited by 367 · see citing works
Self-citationCXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer
Wang, D., Sun, H., Wei, J., Cen, B., & DuBois, R. N. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3199 · Cited by 356 · see citing works
Age-related Impairment of Vascular Structure and Functions
Xu, X., Wang, B. Z., Ren, C., Hu, J., Greenberg, D. A., Chen, T., Xie, L., & Jin, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0430 · Cited by 351 · see citing works
Meyer, C., Sevko, A., Ramacher, M., Bazhin, A. V., Falk, C. S., Osen, W., Borrello, I., Kato, M., Schadendorf, D., Baniyash, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108121108 · Cited by 348 · see citing works
Sherman‐Baust, C. A., Weeraratna, A. T., Rangel, L. B. A., Pizer, E. S., Cho, K. R., Schwartz, D. R., Shock, T. L., & Morin, P. J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00058-8 · Cited by 340 · see citing works
Self-citationMerline, R., Moreth, K., Beckmann, J., Nastase, M. V., Zeng-Brouwers, J., Tralhão, J. G., Lemarchand, P., Pfeilschifter, J., Schaefer, R. M., Iozzo, R. V., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001868 · Cited by 333 · see citing works
Gómez, C. R., Nomellini, V., Faunce, D. E., & Kovacs, E. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.016 · Cited by 328 · see citing works
Hale, J. S., Boursalian, T. E., Turk, G. L., & Fink, P. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601040103 · Cited by 322 · see citing works
Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers
Wang, H., Abhilash, A. S., Chen, C. S., Wells, R. G., & Shenoy, V. B. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.09.044 · Cited by 313 · see citing works
Lee, H., Mullins, S., Franco‐Barraza, J., Valianou, M., Cukierman, E., & Cheng, J. D. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-245 · Cited by 306 · see citing works
Liu, J.-Y., Souroullas, G. P., Diekman, B. O., Krishnamurthy, J., Hall, B. M., Sorrentino, J. A., Parker, J. S., Sessions, G. A., Gudkov, A. V., & Sharpless, N. E. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818313116 · Cited by 306 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Özcan, S., Alessio, N., Acar, M. B., Mert, E., Omerli, F., Peluso, G., & Galderisi, U. (2016) · Aging · doi:10.18632/aging.100971 · Cited by 295 · see citing works
Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer
Sanoff, H. K., Deal, A. M., Krishnamurthy, J., Torrice, C., Dillon, P., Sorrentino, J., Ibrahim, J. G., Jolly, T. A., Williams, G., Carey, L. A., et al. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju057 · Cited by 283 · see citing works
Targeting the Tumor Microenvironment: From Understanding Pathways to Effective Clinical Trials
Hua, F., & DeClerck, Y. A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0661 · Cited by 282 · see citing works
MDSCs: Key Criminals of Tumor Pre-metastatic Niche Formation
Wang, Y., Ding, Y., Guo, N., & Wang, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00172 · Cited by 282 · see citing works
Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2433717100 · Cited by 270 · see citing works
The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy
Schosserer, M., Grillari, J., & Breitenbach, M. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00278 · Cited by 261 · see citing works
Rosenkranz, D., Weyer, S. W., Tolosa, E., Gaenslen, A., Berg, D., Leyhe, T., Gasser, T., & Stoltze, L. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.05.011 · Cited by 255 · see citing works
Olivieri, F., Spazzafumo, L., Santini, G., Lazzarini, R., Albertini, M. C., Rippo, M. R., Galeazzi, R., Abbatecola, A. M., Marcheselli, F., Monti, D., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.09.004 · Cited by 248 · see citing works
Martinez-Outschoorn, U. E., Pavlides, S., Howell, A., Pestell, R. G., Tanowitz, H. B., Sotgia, F., & Lisanti, M. P. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.01.023 · Cited by 248 · see citing works
West, M. D., Pereira‐Smith, O. M., & Smith, J. R. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90372-8 · Cited by 242 · see citing works
Ageing: from inflammation to cancer
Leonardi, G. C., Accardi, G., Monastero, R., Nicoletti, F., & Libra, M. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0112-5 · Cited by 241 · see citing works
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
Salzer, M. C., Lafzi, A., Berenguer, A., Youssif, C., Castellanos‐Martín, A., Solanas, G., Peixoto, F. O., Attolini, C. S., Prats, N., Aguilera, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.012 · Cited by 241 · see citing works
Cell Senescence: Role in Aging and Age-Related Diseases
Campisi, J., & Robert, L. (2014) · Interdisciplinary Topics in Gerontology and Geriatrics · doi:10.1159/000358899 · Cited by 240 · see citing works
High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals
Sharma, S., Dominguez, A. L., & Lustgarten, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8348 · Cited by 240 · see citing works
Millis, A. J. T., Hoyle, M., McCue, H. M., & Martini, H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90286-h · Cited by 239 · see citing works
The autophagic tumor stroma model of cancer
Pavlides, S., Tsirigos, A., Migneco, G., Whitaker‐Menezes, D., Chiavarina, B., Flomenberg, N., Frank, P. G., Casimiro, M. C., Wang, C., Pestell, R. G., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12721 · Cited by 237 · see citing works
Verschoor, C. P., Johnstone, J., Millar, J., Dorrington, M. G., Habibagahi, M., Lelic, A., Loeb, M., Bramson, J. L., & Bowdish, D. M. E. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0912461 · Cited by 235 · see citing works
Tissue Force Programs Cell Fate and Tumor Aggression
Northey, J. J., Przybyla, L., & Weaver, V. M. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0733 · Cited by 235 · see citing works
Ageing and the immune system: focus on macrophages
Linehan, E., & Fitzgerald, D. (2015) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi-d-14-00035 · Cited by 228 · see citing works
Cellular senescence: Immunosurveillance and future immunotherapy
Burton, D. G. A., & Stolzing, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.02.001 · Cited by 221 · see citing works
Severino, V, Alessio, N., Farina, A., Sandomenico, A., Cipollaro, M., Peluso, G., Galderisi, U., & Chambery, A. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.445 · Cited by 214 · see citing works
Chen, Y., Huang, Y., Reiberger, T., Duyverman, A. M. M. J., Huang, P., Samuel, R., Hiddingh, L., Roberge, S., Koppel, C., Lauwers, G. Y., et al. (2013) · Hepatology · doi:10.1002/hep.26790 · Cited by 211 · see citing works
Bauer, J., Büttner, P., Murali, R., Okamoto, I., Kolaitis, N. A., Landi, M. T., Scolyer, R. A., & Bastian, B. C. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00837.x · Cited by 211 · see citing works
Immunosenescence of Human Natural Killer Cells
Gayoso, I., Sánchez-Correa, B., Campos, C., Alonso, C., Pera, A., Casado, J. G., Morgado, S., Tarazona, R., & Solana, R. (2011) · Journal of Innate Immunity · doi:10.1159/000328005 · Cited by 210 · see citing works
Stem cells in cancer therapy: opportunities and challenges
Zhang, C.-L., Huang, T., Wu, B.-L., He, W., & Liu, D. (2017) · Oncotarget · doi:10.18632/oncotarget.20798 · Cited by 204 · see citing works
MicroRNAs linking inflamm-aging, cellular senescence and cancer
Olivieri, F., Rippo, M. R., Monsurrò, V., Salvioli, S., Capri, M., Procopio, A. D., & Franceschi, C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.001 · Cited by 203 · see citing works
SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
Canino, C., Mori, F., Cambria, A., Diamantini, A., Germoni, S., Alessandrini, G., Borsellino, G., Galati, R., Battistini, L., Blandino, R., et al. (2012) · Oncogene · doi:10.1038/onc.2011.485 · Cited by 200 · see citing works
Cellular Senescence and Inflammaging in Age-Related Diseases
Olivieri, F., Prattichizzo, F., Grillari, J., & Balistreri, C. R. (2018) · Mediators of Inflammation · doi:10.1155/2018/9076485 · Cited by 200 · see citing works
Impact of Age on Outcomes with Immunotherapy for Patients with Melanoma
Warner, A. B., Nipp, R. D., Giobbie‐Hurder, A., Johnpulle, R. A. N., Rubin, K. M., Rubinstein, S. M., Flaherty, K. T., Lawrence, D. P., Johnson, D. B., & Sullivan, R. J. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0450 · Cited by 194 · see citing works
Roark, E. F., Keene, D. R., Haudenschild, C. C., Godyna, S., Little, C. D., & Argraves, W. S. (1995) · Journal of Histochemistry & Cytochemistry · doi:10.1177/43.4.7534784 · Cited by 193 · see citing works
Pazolli, E., Alspach, E., Milczarek, A., Prior, J., Piwnica-Worms, D., & Stewart, S. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3386 · Cited by 192 · see citing works
Marcos‐Garcés, V., Aguilar, P. M., Serrano, C. B., García-Bustos, V., Seguí, J. B., Izquierdo, A. F., & Ruiz‐Saurí, A. (2014) · Journal of Anatomy · doi:10.1111/joa.12186 · Cited by 185 · see citing works
Ahmadzadeh, H., Webster, M. R., Behera, R., Valencia, A. M. J., Wirtz, D., Weeraratna, A. T., & Shenoy, V. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617037114 · Cited by 185 · see citing works
Self-citationImmune Infiltration and Prostate Cancer
Strasner, A., & Karin, M. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00128 · Cited by 184 · see citing works
Bone Disease in Multiple Myeloma: Pathophysiology and Management
Hameed, A., Brady, J. J., Dowling, P., CLYNES, M. M., & O’Gorman, P. (2014) · Cancer Growth and Metastasis · doi:10.4137/cgm.s16817 · Cited by 183 · see citing works
Sabnis, A. J., & Bivona, T. G. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.009 · Cited by 183 · see citing works
Mosteiro, L., Pantoja, C., de Martino, A., & Serrano, M. (2018) · Aging Cell · doi:10.1111/acel.12711 · Cited by 182 · see citing works
FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease
Kryczek, I., Liu, R., Wang, G., Wu, K., Shu, X., Szeliga, W., Vatan, L., Finlayson, E. V. A., Huang, E. H., Simeone, D. M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3804 · Cited by 179 · see citing works
Skin ageing: changes of physical properties of human skin in vivo
Diridollou, S., Vabre, V., Berson, M., Vaillant, L., Black, D., Lagarde, J., Grégoire, J., Gall, Y., & Patat, F. (2001) · International Journal of Cosmetic Science · doi:10.1046/j.0412-5463.2001.00105.x · Cited by 178 · see citing works
Hazlehurst, L., & Dalton, W. S. (2001) · Cancer and Metastasis Reviews · doi:10.1023/a:1013156407224 · Cited by 162 · see citing works
Targeting macrophages rescues age‐related immune deficiencies in C57<scp>BL</scp>/6J geriatric mice
Jackaman, C., Radley‐Crabb, H. G., Soffe, Z., Shavlakadze, T., Grounds, M. D., & Nelson, D. J. (2013) · Aging Cell · doi:10.1111/acel.12062 · Cited by 162 · cited 1× · see citing works
“M2 (ref.(133)) states, respectively , both of which have been shown to promote tumorigenesis of various cancer types(135,139);”
BackgroundSingh, H., Kanapuru, B., Smith, C. L., Fashoyin‐Aje, L. A., Myers, A., Kim, G., & Pazdur, R. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.35.15_suppl.10009 · Cited by 158 · see citing works
Sceneay, J., Goreczny, G. J., Wilson, K., Morrow, S., DeCristo, M. J., Ubellacker, J. M., Qin, Y., Laszewski, T., Stover, D. G., Barrera, V., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1454 · Cited by 156 · see citing works
Elzi, D. J., Lai, Y., Song, M., Hakala, K., Weintraub, S. T., & Shiio, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120437109 · Cited by 154 · see citing works
Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice
Zhao, L., Sun, L., Wang, H., Ma, H., Liu, G., & Zhao, Y. X. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0506364 · Cited by 154 · see citing works
Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis
Mavrogonatou, E., Pratsinis, H., Papadopoulou, A., Karamanos, N. K., & Kletsas, D. (2019) · Matrix Biology · doi:10.1016/j.matbio.2017.10.004 · Cited by 153 · see citing works
Ecker, B. L., Kaur, A., Douglass, S. M., Webster, M. R., Almeida, F. V., Marino, G. E., Sinnamon, A. J., Neuwirth, M. G., Alicea, G. M., Ndoye, A., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0168 · Cited by 153 · see citing works
Self-citationNatale, C. A., Li, J., Zhang, J., Dahal, A., Dentchev, T., Stanger, B. Z., & Ridky, T. W. (2018) · eLife · doi:10.7554/elife.31770 · Cited by 152 · see citing works
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
Somasundaram, R., Zhang, G., Fukunaga-Kalabis, M., Perego, M., Krepler, C., Xu, X., Wagner, C., Hristova, D., Zhang, J., Tian, T., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00452-4 · Cited by 151 · see citing works
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study
Shevach, E. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01048 · Cited by 150 · see citing works
Begley, L., Kasina, S., MacDonald, J. W., & Macoska, J. A. (2008) · Cytokine · doi:10.1016/j.cyto.2008.05.012 · Cited by 149 · see citing works
Telomerase activity in ‘immortal’ fish1
Klapper, W., Heidorn, K., Kühne, K., Parwaresch, R. M., & Krupp, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01020-5 · Cited by 148 · see citing works
Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development
Luo, X., Fu, Y., Loza, A. J., Murali, B., Leahy, K. M., Ruhland, M. K., Gang, M., Su, X., Zamani, A., Shi, Y., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.016 · Cited by 141 · see citing works
Partial restoration of T‐cell function in aged mice by in vitro blockade of the PD‐1/ PD‐L1 pathway
Lages, C. S., Lewkowich, I. P., Sproles, A. A., Wills-Karp, M. A., & Chougnet, C. A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00611.x · Cited by 140 · see citing works
Balliet, R. M., Capparelli, C., Guido, C., Pestell, T. G., Martinez‐Outschoorn, U., Zhao, L., Whitaker‐Menezes, D., Chiavarina, B., Pestell, R. G., Howell, A., et al. (2011) · Cell Cycle · doi:10.4161/cc.10.23.18254 · Cited by 138 · see citing works
Cancer and Aging - the Inflammatory Connection
Zinger, A., Cho, W. C. S., & Ben‐Yehuda, A. (2017) · Aging and Disease · doi:10.14336/ad.2016.1230 · Cited by 137 · see citing works
Immunotherapy comes of age: Immune aging & checkpoint inhibitors
Elias, R., Karantanos, T., Sira, E., & Hartshorn, K. L. (2017) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2017.02.001 · Cited by 133 · see citing works
Clinical patterns of metastasis
Leong, S. P. L., Cady, B., Jablons, D. M., García‐Aguilar, J., Reintgen, D. S., Jakub, J. W., Pendas, S., Duhaime, L. A., Cassell, R. T., Gardner, M. S., et al. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-8502-8 · Cited by 132 · see citing works
A Role for Immature Myeloid Cells in Immune Senescence
Enioutina, E. Y., Bareyan, D., & Daynes, R. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002987 · Cited by 130 · see citing works
Lesina, M., Wörmann, S. M., Morton, J. P., Diakopoulos, K. N., Korneeva, O., Wimmer, M., Einwächter, H., Sperveslage, J., Demir, İ. E., Kehl, T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86477 · Cited by 128 · see citing works
Ladomersky, E., Scholtens, D. M., Kocherginsky, M., Hibler, E. A., Bartom, E. T., Otto‐Meyer, S., Zhai, L., Lauing, K. L., Choi, J., Sosman, J. A., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00200 · Cited by 128 · see citing works
Hurez, V. J., Dao, V. A., Liu, A., Pandeswara, S., Gelfond, J., Sun, L., Bergman, M. A., Orihuela, C. J., Galván, V., Padron, A. S., et al. (2015) · Aging Cell · doi:10.1111/acel.12380 · Cited by 127 · see citing works
Engineering the pre-metastatic niche
Aguado, B. A., Bushnell, G. G., Rao, S. S., Jeruss, J. S., & Shea, L. D. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0077 · Cited by 125 · see citing works
Longevity of lobsters is linked to ubiquitous telomerase expression
Klapper, W., Kühne, K., Singh, K. K., Heidorn, K., Parwaresch, R. M., & Krupp, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01357-x · Cited by 123 · see citing works
The role of neutrophils in cancer
Grecian, R., Whyte, M. K. B., & Walmsley, S. R. (2018) · British Medical Bulletin · doi:10.1093/bmb/ldy029 · Cited by 122 · see citing works
Grizzle, W. E., Xu, X., Zhang, S., Stockard, C. R., Liu, C., Yu, S., Wang, J., Mountz, J. D., & Zhang, H. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.003 · Cited by 120 · see citing works
Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., & David, G. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00586-18 · Cited by 119 · see citing works
Elastin Production in Human Skin Fibroblast Cultures and Its Decline with Age
Sephel, G. C., & Davidson, J. M. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12285424 · Cited by 117 · see citing works
Oh, J., Kim, Y. K., Jung, J.-Y., Shin, J.-E., Kim, K. H., Cho, K. H., Eun, H. C., & Chung, J. H. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.02.007 · Cited by 116 · see citing works
Panwar, P., Lamour, G., Mackenzie, N. C. W., Yang, H., Ko, F. C., Li, H., & Brömme, D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.644310 · Cited by 111 · see citing works
Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice
Hurez, V. J., Daniel, B. J., Sun, L., Liu, A., Ludwig, S. M., Kious, M. J., Thibodeaux, S. R., Pandeswara, S., Murthy, K., Livi, C. B., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3019 · Cited by 109 · see citing works
Karjalainen, J. M., Tammi, R., Tammi, M., Eskelinen, M. J., Ågren, U. M., Parkkinen, J. J., Alhava, E. M., & Kosma, V.-M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64608-1 · Cited by 108 · see citing works
Steinberg, S. M., Shabaneh, T. B., Zhang, P., Martyanov, V., Li, Z., Malik, B. T., Wood, T. A., Boni, A., Molodtsov, A. K., Angeles, C. V., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1755 · Cited by 100 · see citing works
The prognostic impact of age in different molecular subtypes of breast cancer
Liedtke, C., Rody, A., Gluz, O., Baumann, K., Beyer, D. A., Kohls, E.-B., Lausen, K., Hanker, L., Holtrich, U., Becker, S., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3491-3 · Cited by 100 · see citing works
Neutrophil immunity of the elderly
Schröder, A., & Rink, L. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00017-4 · Cited by 96 · see citing works
Aging, immune senescence, and immunotherapy: a comprehensive review
Elias, R., Hartshorn, K., Rahma, O., Lin, N., & Snyder-Cappione, J. E. (2018) · Seminars in Oncology · doi:10.1053/j.seminoncol.2018.08.006 · Cited by 96 · see citing works
Cellular senescence: from growth arrest to immunogenic conversion
Burton, D. G. A., & Faragher, R. (2015) · AGE · doi:10.1007/s11357-015-9764-2 · Cited by 95 · see citing works
Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs
Calhoun, C., Shivshankar, P., Saker, M., Sloane, L. B., Livi, C. B., Sharp, Z. D., Orihuela, C. J., Adnot, S., White, E. S., Richardson, A., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu241 · Cited by 92 · see citing works
Impact of Age on Outcomes with Immunotherapy in Patients with Non–Small Cell Lung Cancer
Lichtenstein, M. R., Nipp, R. D., Muzikansky, A., Goodwin, K., Anderson, D., Newcomb, R. A., & Gainor, J. F. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.11.011 · Cited by 92 · see citing works
Lawrenson, K., Grün, B., Benjamin, E. O., Jacobs, I. J., Dafou, D., & Gayther, S. A. (2010) · Neoplasia · doi:10.1593/neo.91948 · Cited by 91 · see citing works
Webster, M. R., Xu, M., Kinzler, K. A., Kaur, A., Appleton, J., O’Connell, M. P., Marchbank, K., Valiga, A. A., Dang, V. M., Perego, M., et al. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12330 · Cited by 86 · see citing works
Self-citationLinton, P., & Thoman, M. L. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.017 · Cited by 86 · see citing works
Ameri, A. H., Tuchayi, S. M., Zaalberg, A., Park, J. H., Ngo, K. H., Li, T., Lopez, E., Colonna, M., Lee, R. T., Mino-Kenudson, M. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815016116 · Cited by 85 · see citing works
Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo
Marsh, E. D., Gonzalez, D. G., Lathrop, E., Boucher, J. D., & Greco, V. (2018) · Cell · doi:10.1016/j.cell.2018.10.013 · Cited by 82 · see citing works
Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression
Sieuwerts, A. M., Vries, J. B.-D., Bosma, P. T., Swiggers, S. J. J., Klijn, J. G. M., Foekens, J. A., & Martens, J. W. M. (2003) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613457 · Cited by 79 · see citing works
Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
Rielland, M., Cantor, D. J., Graveline, R., Hajdu, C., Mara, L., de Diego Diaz, B., Miller, G., & David, G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72619 · Cited by 76 · see citing works
Angiogenesis, Cancer, and Vascular Aging
Moriya, J., & Minamino, T. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00065 · Cited by 74 · see citing works
A generalized theory of age-dependent carcinogenesis
Rozhok, A. I., & DeGregori, J. V. (2019) · eLife · doi:10.7554/elife.39950 · Cited by 73 · see citing works
Educational initiatives in geriatric oncology – Who, why, and how?
Hsu, T. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.07.013 · Cited by 73 · see citing works
Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells
Shimada, Y., Hayashi, M., Nagasaka, Y., Ohno-Iwashita, Y., & Inomata, M. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.05.003 · Cited by 72 · see citing works
PMN-MDSC and arginase are increased in myeloma and may contribute to resistance to therapy
Romano, A., Parrinello, N. L., Cava, P. L., Tibullo, D., Giallongo, C., Camiolo, G., Puglisi, F., Parisi, M. S., Pirosa, M. C., Martino, E. A., et al. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1470929 · Cited by 72 · see citing works
Golomb, L., Sagiv, A., Pateras, I. S., Maly, A., Krizhanovsky, V, Gorgoulis, V. G., Oren, M., & Ben-Yehuda, A. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.21 · Cited by 71 · see citing works
FDA subset analysis of the safety of nivolumab in elderly patients with advanced cancers.
Singh, H., Kim, G., Maher, V. E., Beaver, J. A., Pai-Scherf, L. H., Balasubramaniam, S., Theoret, M. R., Blumenthal, G. M., & Pazdur, R. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.10010 · Cited by 71 · see citing works
Wood, W. A., Krishnamurthy, J., Mitin, N., Torrice, C., Parker, J. S., Snavely, A. C., Shea, T. C., Serody, J. S., & Sharpless, N. E. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.029 · Cited by 69 · see citing works
Chemotherapy-induced changes and immunosenescence of CD8+ T-cells in patients with breast cancer.
Onyema, O. O., Decoster, L., Njemini, R., Forti, L. N., Bautmans, I., Waele, M. D., & Mets, T. F. (2015) · PubMed · Cited by 68 · see citing works
IGF Binding Protein-5 Induces Cell Senescence
Sanada, F., Taniyama, Y., Muratsu, J., Otsu, R., Shimizu, H., Rakugi, H., & Morishita, R. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00053 · Cited by 67 · see citing works
Sidi, R., Pasello, G., Opitz, I., Soltermann, A., Tutic, M., Rehrauer, H., Weder, W., Stahel, R. A., & Felley‐Bosco, E. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.09.044 · Cited by 64 · see citing works
Kim, E., Rebecca, V. W., Smalley, I., Messina, J. L., Mathew, R. A., Maria–Engler, S. S., Basanta, D., Smalley, K. S. M., & Anderson, A. R. A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1720 · Cited by 64 · see citing works
In the Wnt-er of life: Wnt signalling in melanoma and ageing
Kaur, A., Webster, M. R., & Weeraratna, A. T. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.332 · Cited by 64 · see citing works
Self-citationImpairment of gamma/delta T lymphocytes in elderly: implications for immunosenescence
Colonna‐Romano, G., Aquino, A., Bulati, M., Lio, D., Candore, G., Oddo, G., Scialabba, G., Vitello, S., & Caruso, C. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.07.005 · Cited by 63 · see citing works
El‐Khattouti, A., Hassan, M., & Gómez, C. R. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00158 · Cited by 56 · see citing works
Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age
Riley, R. L., Khomtchouk, K. M., & Blomberg, B. B. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.04.008 · Cited by 56 · see citing works
Rozhok, A. I., Salstrom, J. L., & DeGregori, J. V. (2014) · Aging · doi:10.18632/aging.100707 · Cited by 54 · see citing works
Nelson, D. M., McBryan, T., Jeyapalan, J. C., Sedivy, J. M., & Adams, P. D. (2014) · AGE · doi:10.1007/s11357-014-9637-0 · Cited by 52 · see citing works
Morre, M., & Beq, S. (2012) · Targeted Oncology · doi:10.1007/s11523-012-0210-4 · Cited by 51 · see citing works
Mirza, N. N., Correa, M. A. D., Dominguez, A. L., Schrum, A. G., Dong, H., & Lustgarten, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903561 · Cited by 50 · see citing works
Zeng, G., & Millis, A. J. T. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0019 · Cited by 49 · see citing works
Are skin senescence and immunosenescence linked within individuals?
Waaijer, M. E. C., Goldeck, D., Gunn, D. A., van Heemst, D., Westendorp, R. G. J., Pawelec, G., & Maier, A. B. (2019) · Aging Cell · doi:10.1111/acel.12956 · Cited by 48 · see citing works
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The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059 · see citing works
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Chen, Z., Han, F., Du, Y., Shi, H., & Zhou, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01332-8 · Cited by 1,612 · see citing works
Crosby, D., Bhatia, S., Brindle, K. M., Coussens, L. M., Dive, C., Emberton, M., Esener, S., Fitzgerald, R. C., Gambhir, S. S., Kuhn, P., et al. (2022) · Science · doi:10.1126/science.aay9040 · Cited by 1,379 · see citing works
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265 · see citing works
Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance
Marusyk, A., Janiszewska, M., & Polyak, K. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.007 · Cited by 1,009 · see citing works
Cox, T. R. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00329-7 · Cited by 978 · see citing works
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,023 · see citing works
Gerstberger, S. C., Jiang, Q., & Ganesh, K. (2023) · Cell · doi:10.1016/j.cell.2023.03.003 · Cited by 959 · see citing works
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works
Embracing cancer complexity: Hallmarks of systemic disease
Swanton, C., Bernard, E., Abbosh, C., André, F., Auwerx, J. H., Balmain, A., Bar‐Sagi, D., Bernards, R., Bullman, S., DeGregori, J. V., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.009 · Cited by 555 · see citing works
Self-citationImmunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 488 · see citing works
Self-citationTumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Peng, S., Xiao, F., Chen, M., & Gao, H. (2021) · Advanced Science · doi:10.1002/advs.202103836 · Cited by 446 · see citing works
Activated fibroblasts in cancer: Perspectives and challenges
Caligiuri, G., & Tuveson, D. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.015 · Cited by 431 · see citing works
Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 436 · see citing works
The interplay between immunosenescence and age-related diseases
Barbé‐Tuana, F. M., Funchal, G. A., Schmitz, C. R. R., Maurmann, R. M., & Bauer, M. E. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00806-z · Cited by 389 · see citing works
Metastasis-Initiating Cells and Ecosystems
Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372 · see citing works
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
Wagner, J., Wickman, E., DeRenzo, C. C., & Gottschalk, S. M. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.09.015 · Cited by 383 · see citing works
Single-cell spatial landscapes of the lung tumour immune microenvironment
Sorin, M., Rezanejad, M., Karimi, E., Fiset, B., Desharnais, L., Perus, L. J. M., Milette, S., Yu, M. W., Maritan, S. M., Doré, S., et al. (2023) · Nature · doi:10.1038/s41586-022-05672-3 · Cited by 375 · see citing works
Sex disparities matter in cancer development and therapy
Haupt, S., Caramia, F., Klein, S. L., Rubin, J. B., & Haupt, Y. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00348-y · Cited by 333 · see citing works
Finley, L. W. S. (2023) · Cell · doi:10.1016/j.cell.2023.01.038 · Cited by 331 · see citing works
Redox regulation: mechanisms, biology and therapeutic targets in diseases
Li, B., Ming, H., Qin, S., Nice, E. C., Dong, J., Du, Z., & Huang, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02095-6 · Cited by 364 · see citing works
Skin aging from mechanisms to interventions: focusing on dermal aging
Shin, S. H., Lee, Y. H., Rho, N., & Park, K. Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1195272 · Cited by 339 · see citing works
Hallmarks of cancer—Then and now, and beyond
Hanahan, D. (2026) · Cell · doi:10.1016/j.cell.2025.12.049 · Cited by 262 · see citing works
Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
Leon-Ferre, R. A., Jonas, S. F., Salgado, R., Loi, S., de Jong, V., Carter, J. M., Nielsen, T. O., Leung, S. C. Y., Riaz, N., Chia, S., et al. (2024) · JAMA · doi:10.1001/jama.2024.3056 · Cited by 247 · see citing works
The current paradigm and challenges ahead for the dormancy of disseminated tumor cells
Risson, E., Nobre, A. R., Maguer‐Satta, V., & Aguirre‐Ghiso, J. A. (2020) · Nature Cancer · doi:10.1038/s43018-020-0088-5 · Cited by 235 · see citing works
Classical and Nonclassical Intercellular Communication in Senescence and Ageing
Fafián‐Labora, J., & O’Loghlen, A. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.05.003 · Cited by 230 · see citing works
Targeting immune dysfunction in aging
Borgoni, S., Kudryashova, K. S., Burka, K., & de Magalhães, J. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101410 · Cited by 227 · see citing works
Melanoma models for the next generation of therapies
Patton, E. E., Mueller, K. L., Adams, D. J., Anandasabapathy, N., Aplin, A. E., Bertolotto, C., Bosenberg, M., Ceol, C. J., Burd, C. E., Chi, P., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.01.011 · Cited by 204 · see citing works
Self-citationSenescence in osteoarthritis: from mechanism to potential treatment
Liu, Y., Zhang, Z., Li, T., Xu, H., & Zhang, H. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02859-x · Cited by 206 · see citing works
Advances in molecular pathology and therapy of non-small cell lung cancer
Huang, Q., Li, Y., Huang, Y., Wu, J., Bao, W., Xue, C., Li, X., Dong, S., Dong, Z., & Hu, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02243-6 · Cited by 197 · see citing works
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
Yin, Y., Chen, H., Wang, Y., Zhang, L., & Wang, X. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12154 · Cited by 199 · see citing works
Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.03.008 · Cited by 195 · see citing works
“There is growing interest in searching avenues to target senescent cells therapeutically [88].”
BackgroundAgeing of the gut microbiome: Potential influences on immune senescence and inflammageing
Conway, J., & Duggal, N. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101323 · Cited by 194 · see citing works
Age-associated remodeling of T cell immunity and metabolism
Han, S., Georgiev, P., Ringel, A. E., Sharpe, A. H., & Haigis, M. C. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.005 · Cited by 193 · see citing works
Cellular senescence in cancer: from mechanisms to detection
Ou, H., Hoffmann, R. J., González‐López, C., Doherty, G. J., Korkola, J. E., & Muñoz‐Espín, D. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12807 · Cited by 198 · see citing works
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
Zeng, Q., Gong, Y., Zhu, N., Shi, Y., Zhang, C., & Li, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102294 · Cited by 188 · see citing works
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Yuan, S., Almagro, J., & Fuchs, E. V. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-023-00660-9 · Cited by 178 · see citing works
Zheng, S., Wang, W., Shen, L., Yao, Y., Xia, W., & Ni, C. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00543-1 · Cited by 176 · see citing works
Oxidative stress in cancer: from tumor and microenvironment remodeling to therapeutic frontiers
Liang, X., Weng, J., You, Z., Wang, Y., Wen, J., Xia, Z., Huang, S., Luo, P., & Cheng, Q. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02375-x · Cited by 182 · see citing works
Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test
Hinestrosa, J. P., Kurzrock, R., Lewis, J. M., Schork, N. J., Schroeder, G., Kamat, A. M., Lowy, A. M., Eskander, R. N., Perrera, O., Searson, D. J., et al. (2022) · Communications Medicine · doi:10.1038/s43856-022-00088-6 · Cited by 158 · see citing works
Immunosenescence and inflammaging: Mechanisms and role in diseases
Ajoolabady, A., Praticò, D., Tang, D., Zhou, S., Franceschi, C., & Ren, J. T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102540 · Cited by 160 · see citing works
The effect of physical exercise on anticancer immunity
Fiuza‐Luces, C., Valenzuela, P. L., Gálvez, B. G., Ramírez, M. R., López‐Soto, A., Simpson, R. J., & Lucía, A. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00943-0 · Cited by 154 · see citing works
Adhesion-mediated mechanosignaling forces mitohormesis
Tharp, K. M., Higuchi‐Sanabria, R., Timblin, G. A., Ford, B., Garzón-Coral, C., Schneider, C. P., Muncie, J. M., Stashko, C., Daniele, J. R., Moore, A. S., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.017 · Cited by 141 · see citing works
de Jong, V. M. T., Wang, Y., ter Hoeve, N. D., Opdam, M., Stathonikos, N., Jóźwiak, K., Hauptmann, M., Cornelissen, S., Vreuls, W., Rosenberg, E. H., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.01536 · Cited by 139 · see citing works
Ma, J., Liu, Z., Gao, X., Bao, Y., Hong, Y., He, X., Zhu, W., Li, Y., Huang, W., Zheng, N., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106687 · Cited by 131 · see citing works
Periodontitis and risk of cancer: Mechanistic evidence
Baima, G., Minoli, M., Michaud, D. S., Aimetti, M., Sanz, M., Loos, B. G., & Romandini, M. (2023) · Periodontology 2000 · doi:10.1111/prd.12540 · Cited by 131 · see citing works
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
Blokland, K. E. C., Pouwels, S. D., Schuliga, M. J., Knight, D. A., & Burgess, J. K. (2020) · Clinical Science · doi:10.1042/cs20190893 · Cited by 129 · see citing works
The current knowledge concerning solid cancer and therapy
Najafi, M., Majidpoor, J., Toolee, H., & Mortezaee, K. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22900 · Cited by 131 · see citing works
Guo, Z., Zhang, H., Fu, Y., Kuang, J., Zhao, B., Zhang, L., Lin, J., Lin, S., Wu, D., & Xie, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01306-3 · Cited by 126 · see citing works
An integrative analysis of the age-associated multi-omic landscape across cancers
Chatsirisupachai, K., Lesluyes, T., Paraoan, L., Loo, P. V., & de Magalhães, J. P. (2021) · Nature Communications · doi:10.1038/s41467-021-22560-y · Cited by 122 · see citing works
Sex and gender perspectives in colorectal cancer
Baraibar, I., Ros, J., Gonzalez, N. S., Salvà, F., Garcia, A. R., Castells, M. R., Tabernero, J. M., & Élez, E. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.101204 · Cited by 121 · see citing works
Immune-checkpoint inhibitor resistance in cancer treatment: Current progress and future directions
Zhang, C., Zhang, C., & Wang, H. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216182 · Cited by 125 · see citing works
Bourgot, I., Primac, I., Louis, T., Noël, A., & Maquoi, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01488 · Cited by 113 · see citing works
Zhao, Y., Dong, Y., Yang, S., Tu, Y., Wang, C., Li, J., Yuan, Y., & Lian, Z.-X. (2022) · ACS Central Science · doi:10.1021/acscentsci.2c00163 · Cited by 111 · see citing works
The translational challenges of precision oncology
Pich, O., Bailey, C., Watkins, T. B. K., Zaccaria, S., Jamal‐Hanjani, M., & Swanton, C. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.04.002 · Cited by 111 · see citing works
Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies
D’Ambrosio, M., & Gil, J. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.05.010 · Cited by 106 · see citing works
Targeting senescence as an anticancer therapy
Bousset, L., & Gil, J. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13312 · Cited by 108 · see citing works
Cellular Senescence and Ageing: Mechanisms and Interventions
Mylonas, A., & O’Loghlen, A. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.866718 · Cited by 111 · see citing works
Hayashi, Y., Makino, T., Sato, E., Ohshima, K., Nogi, Y., Kanemura, T., Honma, K., Yamashita, K., Saito, T., Tanaka, K., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02235-9 · Cited by 107 · see citing works
Senescent cells and macrophages: key players for regeneration?
Elder, S. S., & Emmerson, E. (2020) · Open Biology · doi:10.1098/rsob.200309 · Cited by 109 · see citing works
de Jong, V. M. T., Wang, Y., ter Hoeve, N. D., Opdam, M., Stathonikos, N., Jóźwiak, K., Hauptmann, M., Cornelissen, S., Vreuls, W., Rosenberg, E. H., et al. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-217984 · Cited by 100 · see citing works
Fisher, G. J., Wang, B., Cui, Y., Shi, M., Zhao, Y., Quan, T., & Voorhees, J. J. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00743-0 · Cited by 103 · see citing works
T Cell Fitness and Autologous CAR T Cell Therapy in Haematologic Malignancy
Mehta, P. H., Fiorenza, S., Koldej, R. M., Jaworowski, A., Ritchie, D. S., & Quinn, K. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.780442 · Cited by 98 · see citing works
Fumagalli, C., & Barberis, M. C. P. (2021) · Diagnostics · doi:10.3390/diagnostics11091555 · Cited by 97 · see citing works
Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications
Wu, X., Li, Y., Wen, M., Xie, Y., Zeng, K., Liu, Y., Chen, W., & Zhao, Y. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00673e · Cited by 97 · see citing works
The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
Chen, Y., Zheng, X., & Wu, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.792691 · Cited by 100 · see citing works
Bachmann, M. C., Bellalta, S., Basoalto, R., Gómez‐Valenzuela, F., Jalil, Y., Lépez, M., Matamoros, A., & Rommy von Bernhardi, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570083 · Cited by 96 · see citing works
Turrell, F. K., Orha, R., Guppy, N., Gillespie, A., Guelbert, M., Starling, C., Haider, S. A., & Isacke, C. M. (2023) · Nature Cancer · doi:10.1038/s43018-023-00525-y · Cited by 90 · see citing works
Elyahu, Y., & Monsonego, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101231 · Cited by 91 · see citing works
Dong, B., Wu, C., Huang, L., & Qi, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.739358 · Cited by 88 · see citing works
Huang, Z., Yao, D., Ye, Q., Jiang, H., Gu, R., Ji, C., Wu, J., Hu, Y., & Yuan, A. (2021) · ACS Nano · doi:10.1021/acsnano.0c10764 · Cited by 88 · see citing works
p53/MDM2 signaling pathway in aging, senescence and tumorigenesis
Huang, Y., Che, X., Wang, P., & Qu, X. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.05.001 · Cited by 92 · see citing works
Zhang, F., Guo, J., Yu, S., Zheng, Y., Duan, M., Zhao, L., Wang, Y., Yang, Z., & Jiang, X. (2024) · 癌症：英文版 · doi:10.1002/cac2.12591 · Cited by 93 · see citing works
The fibrotic and immune microenvironments as targetable drivers of metastasis
Boulter, L., Bullock, E., Mabruk, Z., & Brunton, V. G. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01172-1 · Cited by 78 · see citing works
Zhang, Q., An, Z.-Y., Jiang, W. G., Jin, W., & He, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115390 · Cited by 79 · see citing works
Chen, B., Chan, W. N., Xie, F., Mui, C. W., Liu, X., Cheung, A. H. K., Lung, R. W. M., Chow, C., Zhang, Z., Fang, C., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1516 · Cited by 80 · see citing works
Age-associated differences in the cancer molecular landscape
Chatsirisupachai, K., Lagger, C., & de Magalhães, J. P. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.06.007 · Cited by 78 · see citing works
Immune Aging and Immunotherapy in Cancer
Kaiser, M., Semeraro, M. D., Herrmann, M., Absenger, G., Gerger, A., & Renner, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137016 · Cited by 78 · see citing works
Morillon, Y. M., Sabzevari, A., Schlom, J., & Greiner, J. W. (2020) · Anticancer Research · doi:10.21873/anticanres.14540 · Cited by 72 · see citing works
Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T. M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025647118 · Cited by 74 · see citing works
The effects of age and systemic metabolism on anti-tumor T cell responses
Drijvers, J. M., Sharpe, A. H., & Haigis, M. C. (2020) · eLife · doi:10.7554/elife.62420 · Cited by 69 · see citing works
Wang, X., Liu, C., Chen, J., Chen, L., Ren, X., Hou, M., Cui, X., Jiang, Y., Liu, E., Zong, Y., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00445-8 · Cited by 68 · see citing works
Chhabra, Y., Fane, M. E., Pramod, S., Hüser, L., Zabransky, D. J., Wang, V., Dixit, A., Zhao, R., Kumah, E., Brezka, M. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.013 · Cited by 73 · see citing works
Self-citationPan-cancer analysis reveals molecular patterns associated with age
Shah, Y., Verma, A., Marderstein, A. R., White, J. B., Bhinder, B., Medina, J. S. G., & Elemento, O. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110100 · Cited by 67 · see citing works
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
Zhuang, X., Wang, Q., Joost, S., Ferrena, A., Humphreys, D. T., Li, Z., Blum, M., Krause, K., Ding, S., Landais, Y., et al. (2024) · Nature · doi:10.1038/s41586-024-08285-0 · Cited by 70 · see citing works
DNA repair as a shared hallmark in cancer and ageing
Clarke, T. L., & Mostoslavsky, R. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13285 · Cited by 68 · see citing works
Zhao, B., Wu, B. C., Feng, N., Zhang, X., Zhang, X., Wei, Y., & Zhang, W. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01426-4 · Cited by 65 · see citing works
Piwócka, O., Piotrowski, I., Suchorska, W. M., & Kulcenty, K. I. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1343523 · Cited by 64 · see citing works
Barbosa, J. R., & de Carvalho, R. N. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116613 · Cited by 64 · see citing works
Shared genetic and epigenetic changes link aging and cancer
Zabransky, D. J., Jaffee, E. M., & Weeraratna, A. T. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.01.004 · Cited by 64 · see citing works
Self-citationSato, R., Imamura, K., Semba, T., Tomita, Y., Saeki, S., Ikeda, K., Komohara, Y., Suzuki, M., Sakagami, T., Saya, H., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3941 · Cited by 60 · see citing works
Tumor microenvironment and nanotherapeutics: intruding the tumor fort
Kiran, A. V. V. V. R., Kumari, G. K., Krishnamurthy, P. T., & Khaydarov, R. R. (2021) · Biomaterials Science · doi:10.1039/d1bm01127h · Cited by 60 · see citing works
The importance of aging in cancer research
(2022) · Nature Aging · doi:10.1038/s43587-022-00231-x · Cited by 60 · see citing works
Cancer Evo–Dev: A Theory of Inflammation-Induced Oncogenesis
Liu, W., Deng, Y., Li, Z., Chen, Y., Zhu, X., Tan, X., & Cao, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.768098 · Cited by 59 · see citing works
Intrapancreatic fat, pancreatitis, and pancreatic cancer
Lilly, A. C., Astsaturov, I. A., & Golemis, E. A. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04855-z · Cited by 59 · see citing works
Zhan, L., Feng, H.-F., Liu, H., Guo, L., Chen, C., Yao, X.-L., & Sun, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.649863 · Cited by 60 · see citing works
Cerchietti, L. C. A. (2024) · Blood · doi:10.1182/blood.2023021002 · Cited by 60 · see citing works
Adaptations of neutrophils in cancer
Ng, M. S. F., Cerezo‐Wallis, D., Ng, L. G., & Hidalgo, A. (2025) · Immunity · doi:10.1016/j.immuni.2024.12.009 · Cited by 58 · see citing works
- Authors
- Fane, M., & Weeraratna, A. T.
- Affiliations
- The Wistar Institute (US)
- Corresponding author
- Fane, Mitchell
- Weeraratna, Ashani T.
- Venue
- Nature Reviews Cancer
- Published
- 2019-12-13
- Volume
- 20
- Issue
- 2
- Pages
- 89-106
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC7377404
- OpenAlex
- W2995607278
- Cited by
- 849
- References
- 228
- Citations by year
- 2026: 109 · 2025: 176 · 2024: 166 · 2023: 130 · 2022: 122 · 2021: 92 · 2020: 54
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA207935, P01CA114046, R01CA174746, R01CA232256, P30CA010815, P30CA006973)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- tumor microenvironment, aging, tumor progression, extracellular matrix, secreted factors, cancer therapy response, tumour metastasis, preclinical mouse models
- MeSH terms
- Aging, Animals, Cell Transformation, Neoplastic, Combined Modality Therapy, Extracellular Matrix, Humans, Neoplasms, Treatment Outcome, Stromal Cells, Disease Progression, Tumor Microenvironment
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