Rudolph, Karl Lenhard

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,349

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,019

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 592

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

WIEMANN, S. U., SATYANARAYANA, A., TSAHURIDU, M., TILLMANN, H. L., ZENDER, L., KLEMPNAUER, J., FLEMMING, P., FRANCO, S., BLASCO, M. A., MANNS, M. P., et al. (2002) · The FASEB Journal

Telomeres, Telomerase, and SenescenceLiver physiology and pathology

Cited by 527

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

Rudolph, K. L., Millard, M., Bosenberg, M. W., & DePinho, R. A. (2001) · Nature Genetics

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 527

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Choudhury, A. R., Ju, Z., Djojosubroto, M. W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., et al. (2007) · Nature Genetics

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 426

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

Rudolph, K. L., Chang, S., Millard, M., Schreiber-Agus, N., & DePinho, R. A. (2000) · Science

Telomeres, Telomerase, and SenescenceLiver physiology and pathology

Cited by 424

DNA damage checkpoints in stem cells, ageing and cancer

Sperka, T., Wang, J., & Rudolph, K. L. (2012) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 393

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

Wang, J., Sun, Q., Morita, Y., Jiang, H., Groß, A., Lechel, A., Hildner, K., Guachalla, L. M., Gompf, A., Hartmann, D., et al. (2012) · Cell

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 343

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Wong, K.-K., Chang, S., Weiler, S. R., Ganesan, S., Chaudhuri, J., Zhu, C., Artandi, S. E., Rudolph, K. L., Gottlieb, G. J., Chin, L., et al. (2000) · Nature Genetics

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 309

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

Schwitalla, S., Ziegler, P. K., Horst, D., Becker, V., Kerle, I., Begus-Nahrmann, Y., Lechel, A., Rudolph, K. L., Langer, R., Slotta-Huspenina, J., et al. (2013) · Cancer Cell

Cancer-related Molecular PathwaysGenetic factors in colorectal cancer

Cited by 296

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

Ju, Z., Jiang, H., Jaworski, M., Rathinam, C., Gompf, A., Klein, C., Trumpp, A., & Rudolph, K. L. (2007) · Nature Medicine

Hematopoietic Stem Cell TransplantationTelomeres, Telomerase, and Senescence

Cited by 284

Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

Sanoff, H. K., Deal, A. M., Krishnamurthy, J., Torrice, C., Dillon, P., Sorrentino, J., Ibrahim, J. G., Jolly, T. A., Williams, G., Carey, L. A., et al. (2014) · JNCI: Journal of the National Cancer Institute

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 283

Cellular and epigenetic drivers of stem cell ageing

Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 272

Impact of genomic damage and ageing on stem cell function

Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 207

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

Jiang, H., Schiffer, E., Song, Z., Wang, J., Zürbig, P., Thedieck, K., Moes, S., Bantel, H., Saal, N., Jantos, J., et al. (2008) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 169

Telomere shortening and ageing

Jiang, H., Ju, Z., & Rudolph, K. L. (2007) · Zeitschrift für Gerontologie und Geriatrie

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 165

Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis

Hemann, M. T., Rudolph, K. L., Strong, M. A., DePinho, R. A., Chin, L., & Greider, C. W. (2001) · Molecular Biology of the Cell

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 162

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Tang, D., Tao, S., Chen, Z., Koliesnik, I. O., Calmes, P. G., Hoerr, V., Han, B., Gebert, N., Zörnig, M., Löffler, B., et al. (2016) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

Cited by 133

Immunoaging induced by hematopoietic stem cell aging

Wang, J., Geiger, H., & Rudolph, K. L. (2011) · Current Opinion in Immunology

Hematopoietic Stem Cell TransplantationTelomeres, Telomerase, and Senescence

Cited by 107

Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice

Rolyan, H., Scheffold, A., Heinrich, A., Begus-Nahrmann, Y., Langkopf, B. H., Hölter, S. M., Vogt-Weisenhorn, D. M., Liss, B., Wurst, W., Lie, D. C., et al. (2011) · Brain

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 106

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

Gebert, N., Cheng, C.-W., Kirkpatrick, J. M., Di Fraia, D., Yun, J., Schädel, P., Pace, S., Garside, G. B., Werz, O., Rudolph, K. L., et al. (2020) · Cell Reports

Genetics, Aging, and Longevity in Model OrganismsDigestive system and related health

Cited by 88

Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion

Meena, J. K., Cerutti, A., Beichler, C., Morita, Y., Bruhn, C., Kumar, M., Kraus, J. M., Speicher, M. R., Wang, Z., Kestler, H. A., et al. (2015) · The EMBO Journal

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 87

Wound healing defect of Vav3−/− mice due to impaired β2-integrin–dependent macrophage phagocytosis of apoptotic neutrophils

Sindrilaru, A., Peters, T., Schymeinsky, J., Oreshkova, T., Wang, H., Gompf, A., Mannella, F., Wlaschek, M., Sunderkötter, C., Rudolph, K. L., et al. (2009) · Blood

Wound Healing and TreatmentsPhagocytosis and Immune Regulation

Cited by 73