The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy
Open accessAbstract
The genetic modification and characterization of T-cells with chimeric antigen receptors (CARs) allow functionally distinct T-cell subsets to recognize specific tumor cells. The incorporation of costimulatory molecules or cytokines can enable engineered T-cells to eliminate tumor cells. CARs are generated by fusing the antigen-binding region of a monoclonal antibody (mAb) or other ligand to membrane-spanning and intracellular-signaling domains. They have recently shown clinical benefit in patients treated with CD19-directed autologous T-cells. Recent successes suggest that the modification of T-cells with CARs could be a powerful approach for developing safe and effective cancer therapeutics. Here, we briefly review early studies, consider strategies to improve the therapeutic potential and safety, and discuss the challenges and future prospects for CAR T-cells in cancer therapy.
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Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
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Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia
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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
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Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
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Self-citationKalos, M., Levine, B. L., Porter, D. L., Katz, S., Grupp, S. A., Bagg, A., & June, C. H. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002842 · Cited by 2,388
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Chimeric antigen receptor T-cell therapy—assessment and management of toxicities
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New approaches and procedures for cancer treatment: Current perspectives
Debela, D. T., Muzazu, S. G., Heraro, K. D., Ndalama, M. T., Mesele, B. W., Haile, D. C., Kitui, S. K., & Manyazewal, T. (2021) · SAGE Open Medicine · doi:10.1177/20503121211034366 · Cited by 1,597
Cancer treatment therapies: traditional to modern approaches to combat cancers
Kaur, R., Bhardwaj, A., & Gupta, S. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08809-3 · Cited by 561
New development in CAR-T cell therapy
Wang, Z., Wu, Z., Liu, Y., & Han, W. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0423-1 · Cited by 396
Self-citationHarnessing tumor‐associated macrophages as aids for cancer immunotherapy
Li, X., Liu, R., Su, X., Pan, Y., Han, X., Shao, C., & Shi, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1102-3 · Cited by 364
Metadata
- Authors
- Dai, H., Wang, Y., Lu, X., & Han, W.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01-27
- Volume
- 108
- Issue
- 7
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2316953565
- Cited by
- 299
- References
- 157
- FWCI
- 19.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dai, H., Wang, Y., Lu, X., & Han, W. (2016). Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy. JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/djv439
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
