Impact of Epithelial–Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ
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Background: A better definition of biomarkers and biological processes related to local recurrence and disease progression is highly warranted for ductal breast carcinoma in situ (DCIS). Stromal–epithelial interactions are likely of major importance for the biological, clinical, and pathological distinctions between high- and low-risk DCIS cases. Methods: Stromal platelet derived growth factor receptor (PDGFR) was immunohistochemically assessed in two DCIS patient cohorts (n = 458 and n = 80). Cox proportional hazards models were used to calculate the hazard ratios of recurrence. The molecular mechanisms regulating stromal PDGFR expression were investigated in experimental in vitro co-culture systems of DCIS cells and fibroblasts and analyzed using immunoblot and quantitative real-time PCR. Knock-out of JAG1 in DCIS cells and NOTCH2 in fibroblasts was obtained through CRISPR/Cas9. Experimental data were validated by mammary fat pad injection of DCIS and DCIS-JAG1 knock-out cells (10 mice per group). All statistical tests were two-sided. Results: PDGFRα(low)/PDGFRβ(high) fibroblasts were associated with increased risk for recurrence in DCIS (univariate hazard ratio = 1.59, 95% confidence interval [CI] = 1.02 to 2.46; P = .04 Wald test; multivariable hazard ratio = 1.78, 95% CI = 1.07 to 2.97; P = .03). Tissue culture and mouse model studies indicated that this fibroblast phenotype is induced by DCIS cells in a cell contact-dependent manner. Epithelial Jagged1 and fibroblast Notch2 were identified through loss-of-function studies as key juxtacrine signaling components driving the formation of the poor prognosis-associated fibroblast phenotype. Conclusions: A PDGFRα(low)/PDGFRβ(high) fibroblast subset was identified as a marker for high-risk DCIS. The Jagged-1/Notch2/PDGFR stroma–epithelial pathway was described as a novel signaling mechanism regulating this poor prognosis-associated fibroblast subset. In general terms, the study highlights epithelial–stromal crosstalk in DCIS and contributes to ongoing efforts to define clinically relevant fibroblast subsets and their etiology.
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Contact between cancer cells and fibroblasts can promote the CAF phenotype in breast cancer through Notch signalling.
“Contact between cancer cells and fibroblasts can promote the CAF phenotype in breast cancer through Notch signalling55”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [55]
Cites
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works
Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681 · see citing works
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590 · see citing works
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085 · see citing works
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569 · see citing works
GAGE: generally applicable gene set enrichment for pathway analysis
Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333 · see citing works
Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5
Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G., & Quaranta, V. (1997) · Science · doi:10.1126/science.277.5323.225 · Cited by 1,221 · see citing works
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
McAllister, S. S., & Weinberg, R. A. (2014) · Nature Cell Biology · doi:10.1038/ncb3015 · Cited by 966 · see citing works
Rosen, P. P. (1997) · Cited by 820 · see citing works
Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways
Boelens, M., Wu, T. J., Nabet, B., Xu, B.-H., Qiu, Y., Yoon, T., Azzam, D. J., Victor, C. T.-S., Wiemann, B., Ishwaran, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.051 · Cited by 768 · see citing works
Gene expression profiling of the tumor microenvironment during breast cancer progression
Ma, X., Dahiya, S. M., Richardson, E., Erlander, M. G., & Sgroi, D. C. (2009) · Breast Cancer Research · doi:10.1186/bcr2222 · Cited by 618 · see citing works
Ductal Carcinoma In Situ of the Breast: A Systematic Review of Incidence, Treatment, and Outcomes
Virnig, B. A., Tuttle, T. M., Shamliyan, T., & Kane, R. L. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp482 · Cited by 610 · see citing works
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Cox, T. R., Bird, D., Baker, A.-M., Barker, H. E., Ho, M. W.-Y., Lang, G., & Erler, J. T. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2233 · Cited by 571 · see citing works
Cancer-associated fibroblasts and tumor growth – bystanders turning into key players
Östman, A., & Augsten, M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.01.003 · Cited by 542 · see citing works
Self-citationGrases, P. J. (2002) · Progresos de Obstetricia y Ginecología · doi:10.1016/s0304-5013(02)75784-1 · Cited by 499 · see citing works
Regulation of In Situ to Invasive Breast Carcinoma Transition
Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D. R., Richardson, A. L., Violette, S. M., Nikolskaya, T., Nikolsky, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.007 · Cited by 497 · see citing works
Therapeutic modulation of Notch signalling — are we there yet?
Andersson, E. R., & Lendahl, U. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4252 · Cited by 452 · see citing works
Self-citationInhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.
Pietras, K., Rubin, K., Sjöblom, T., Buchdunger, E., Sjöquist, M., Heldin, C., & Östman, A. (2002) · PubMed · Cited by 432 · see citing works
Self-citationSheldon, H., Heikamp, E., Turley, H., Dragovic, R., Thomas, P. H., Oon, C. E., Leek, R., Edelmann, M. J., Kessler, B. M., Sainson, R. C. A., et al. (2010) · Blood · doi:10.1182/blood-2009-08-239228 · Cited by 409 · see citing works
Liu, H., Kennard, S., & Lilly, B. (2009) · Circulation Research · doi:10.1161/circresaha.108.184846 · Cited by 286 · see citing works
Cohen, M., Γεωργίου, Μ., Stevenson, N. L., Miodownik, M. A., & Baum, B. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.006 · Cited by 272 · see citing works
Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin.
Albrechtsen, R., Nielsen, M., Wewer, U. M., Engvall, E., & Ruoslahti, E. I. (1981) · PubMed · Cited by 269 · see citing works
Paulsson, J., Sjöblom, T., Micke, P., Pontén, F., Landberg, G., Heldin, C., Bergh, J. C. S., Brennan, D. J., Jirström, K., & Östman, A. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081030 · Cited by 267 · see citing works
Self-citationFibroblasts as architects of cancer pathogenesis
Marsh, T., Pietras, K., & McAllister, S. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.013 · Cited by 263 · see citing works
Self-citationProgression from ductal carcinoma in situ to invasive breast cancer: Revisited
Cowell, C. F., Weigelt, B., Sakr, R. A., Ng, C. K. Y., Hicks, J. B., King, T. A., & Reis-Filho, J. S. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.07.005 · Cited by 259 · see citing works
Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition
del Alcazar, C. R. G., Huh, S. J., Ekram, M. B., Trinh, A. C., Liu, L. L., de Beça, F. F., Zi, X., Kwak, M., Bergholtz, H., Su, Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0222 · Cited by 249 · see citing works
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Procopio, M.-G., Laszlo, C., Al Labban, D., Kim, D. E., Bordignon, P., Jo, S.-H., Goruppi, S., Menietti, E., Ostano, P., Ala, U., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3228 · Cited by 223 · see citing works
Hu, M. S., Peluffo, G., Chen, H., Gelman, R. S., Schnitt, S. J., & Polyák, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813306106 · Cited by 205 · see citing works
Furuhashi, M., Sjöblom, T., Abramsson, A., Ellingsen, J., Micke, P., Li, H., Folestad, E. B., Eriksson, U., Heuchel, R. L., Betsholtz, C., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1489 · Cited by 204 · see citing works
Self-citationJin, S., Hansson, E. M., Tikka, S., Lanner, F., Sahlgren, C., Farnebo, F. A., Baumann, M., Kalimo, H., & Lendahl, U. (2008) · Circulation Research · doi:10.1161/circresaha.107.167965 · Cited by 197 · see citing works
Self-citationSTC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Peña, C., Céspedes, M. V., Lindh, M. B., Kiflemariam, S., Mezheyeuski, A., Edqvist, P.-H. D., Hägglöf, C., Birgisson, H., Bojmar, L., Jirström, K., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1875 · Cited by 182 · see citing works
Self-citationInvolvement of platelet‐derived growth factor ligands and receptors in tumorigenesis
Heldin, C. ‐., Lennartsson, J., & Westermark, B. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12690 · Cited by 181 · see citing works
Previs, R. A., Coleman, R. L., Harris, A. L., & Sood, A. K. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0809 · Cited by 173 · see citing works
Integrated Genomic and Transcriptomic Analysis of Ductal Carcinoma In situ of the Breast
Vincent‐Salomon, A., Lucchesi, C., Gruel, N., Raynal, V., Pierron, G., Goudefroye, R., Reyal, F., Radvanyi, F., Salmon, R. J., Thiery, J. P., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1465 · Cited by 156 · see citing works
Roswall, P., Bocci, M., Bartoschek, M., Li, H., Kristiansen, G., Jansson, S., Lehn, S., Sjölund, J., Reid, S., Larsson, C., et al. (2018) · Nature Medicine · doi:10.1038/nm.4494 · Cited by 150 · see citing works
Self-citationStromal caveolin-1 levels predict early DCIS progression to invasive breast cancer
Witkiewicz, A. K., Dasgupta, A., Nguyen, K., Liu, C., Kovatich, A. J., Schwartz, G. F., Pestell, R. G., Sotgia, F., Rui, H., & Lisanti, M. P. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.11.8874 · Cited by 128 · see citing works
Cohort Profile: The Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA)
Gabrielson, M., Eriksson, M., Hammarström, M., Borgquist, S., Leifland, K., Czene, K., & Hall, P. N. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw357 · Cited by 123 · see citing works
Self-citationWide Distribution of Laminin-5 γ2 Chain in Basement Membranes of Various Human Tissues
Mizushima, H., Koshikawa, N., Moriyama, K., Takamura, H., Nagashima, Y., Hirahara, F., & Miyazaki, K. (1998) · Hormone Research in Paediatrics · doi:10.1159/000053118 · Cited by 111 · see citing works
Hägglöf, C., Hammarsten, P., Josefsson, A., Stattin, P. E., Paulsson, J., Bergh, A. R. J., & Östman, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010747 · Cited by 109 · see citing works
Self-citationEhnman, M., Missiaglia, E., Folestad, E. B., Selfe, J., Strell, C., Thway, K., Brodin, B. A., Pietras, K., SHIPLEY, J. M., Östman, A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1646 · Cited by 98 · see citing works
Self-citationNotch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity
Funahashi, Y., Shawber, C. J., Sharma, A., Kanamaru, E., Choi, Y. K., & Kitajewski, J. (2011) · Vascular Cell · doi:10.1186/2045-824x-3-2 · Cited by 91 · see citing works
Östman, A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.022 · Cited by 90 · see citing works
Self-citationJansson, S., Aaltonen, K. E., Bendahl, P., Falck, A., Karlsson, M. E., Pietras, K., & Rydén, L. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4664-7 · Cited by 88 · see citing works
Self-citationNordby, Y., Richardsen, E. H., Rakaee, M., Ness, N., Dønnem, T., Patel, H., Busund, L., Bremnes, R. M., & Andersen, S. (2017) · Scientific Reports · doi:10.1038/srep43378 · Cited by 76 · see citing works
Johnson, C. E., Gorringe, K. L., Thompson, E. R., Opeskin, K., Boyle, S. E., Wang, Y.-K., Hill, P., Mann, G. B., & Campbell, I. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1835-1 · Cited by 67 · see citing works
Second events following ductal carcinoma in situ of the breast: a register-based cohort study
Falk, R. S., Hofvind, S. S. H., Skaane, P., & Haldorsen, T. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1531-1 · Cited by 56 · see citing works
Ductal carcinoma in situ of the breast: the importance of morphologic and molecular interactions
Gargano, S., Bombonati, A., & Palazzo, J. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.11.003 · Cited by 55 · see citing works
Corvigno, S., Wisman, G. B. A., Mezheyeuski, A., van der Zee, A. G. J., Nijman, H. W., Åvall-Lundqvist, E. H., Östman, A., & Dahlstrand, H. M. (2016) · Oncotarget · doi:10.18632/oncotarget.7613 · Cited by 46 · see citing works
Self-citationHigh expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer
Paulsson, J., Rydén, L., Strell, C., Frings, O., Tobin, N. P., Fornander, T., Bergh, J. C. S., Landberg, G., Stål, O., & Östman, A. (2016) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.56 · Cited by 43 · see citing works
Self-citationMartins, D. F., de Beça, F. F., Sousa, B., Baltazar, F., Paredes, J., & Schmitt, F. C. (2013) · Cell Cycle · doi:10.4161/cc.25794 · Cited by 42 · see citing works
Zhou, W., Jirström, K., Johansson, C., Amini, R., BLOMQVIST, C. P., Agbaje, O. F., & Wärnberg, F. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-653 · Cited by 41 · see citing works
Self-citationBlaise, R., Mahjoub, M., Salvat, C., Barbe, U., Brou, C., Corvol, M. T., Savouret, J., Rannou, F., Berenbaum, F., & Bausero, P. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24250 · Cited by 39 · see citing works
Identifying progression predictors of breast ductal carcinoma in situ
Yeong, J. P.-S., Thike, A. A., Tan, P. H., & Iqbal, J. (2016) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2016-204154 · Cited by 36 · see citing works
Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells
Braune, E.-B., Tsoi, Y. L., Phoon, Y. P., Landor, S. K.-J., Cascales, H. S., Ramsköld, D., Deng, Q., Lindqvist, A., Lian, X. L., Sahlgren, C., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.03.004 · Cited by 35 · see citing works
Self-citationKarlsson, E., Sandelin, K., Appelgren, J., Zhou, W., Jirström, K., Bergh, J. C. S., & Wärnberg, F. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.10.020 · Cited by 29 · see citing works
Self-citationWadsten, C., Heyman, H., Holmqvist, M., Ahlgren, J., Lambe, M. P., Sund, M., & Wärnberg, F. (2016) · Acta Oncologica · doi:10.1080/0284186x.2016.1211317 · Cited by 21 · see citing works
Self-citationZhou, W., Johansson, C., Jirström, K., Ringberg, A., BLOMQVIST, C. P., Amini, R., Fjällskog, M.-L., & Wärnberg, F. (2013) · International Journal of Breast Cancer · doi:10.1155/2013/582134 · Cited by 19 · see citing works
Self-citationA contribution to the natural history of breast cancer
Tulusan, A. H., Grünsteidel, W., Ramming, I., & Egger, H. (1982) · Archives of Gynecology and Obstetrics · doi:10.1007/bf02110120 · Cited by 16 · see citing works
Rajan, P. B., & Perry, R. H. (1995) · The Breast Journal · doi:10.1111/j.1524-4741.1995.tb00255.x · Cited by 3 · see citing works
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A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · see citing works
Notch signaling pathway: architecture, disease, and therapeutics
Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,145 · see citing works
Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.
Kieffer, Y., Hocine, H. R., Gentric, G., Pelon, F., Bernard, C., Bourachot, B., Lameiras, S., Albergante, L., Bonneau, C., Guyard, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1384 · Cited by 910 · see citing works
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 440 · see citing works
Pelon, F., Bourachot, B., Kieffer, Y., Magagna, I., Mermet‐Meillon, F., Bonnet, I., Costa, A., Givel, A.-M., Atieh, Y., Barbazán, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14134-w · Cited by 392 · see citing works
Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities
Hu, D., Li, Z., Zheng, B., Lin, X., Pan, Y., Gong, P., Zhuo, W., Hu, Y., Chen, C., Chen, L., et al. (2022) · 癌症:英文版 · doi:10.1002/cac2.12291 · Cited by 293 · see citing works
Targeting Notch in oncology: the path forward
Majumder, S., Crabtree, J. S., Golde, T. E., Minter, L. M., Osborne, B. A., & Miele, L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00091-3 · Cited by 274 · see citing works
Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies
Mhaidly, R., & Mechta‐Grigoriou, F. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101417 · Cited by 258 · see citing works
Mhaidly, R., & Mechta‐Grigoriou, F. (2021) · Immunological Reviews · doi:10.1111/imr.12978 · Cited by 231 · see citing works
Liu, Y., Sinjab, A. F., Min, J., Han, G., Paradiso, F., Zhang, Y., Wang, R., Pei, G., Dai, Y., Liu, Y., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.004 · Cited by 249 · see citing works
Epithelial cells activate fibroblasts to promote esophageal cancer development
Chen, Y., Zhu, S., Liu, T., Zhang, S., Lu, J., Fan, W., Lin, L., Xiang, T., Yang, J., Zhao, X., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.03.001 · Cited by 207 · see citing works
Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression
Primac, I., Maquoi, E., Blacher, S., Heljäsvaara, R., Deun, J. V., Smeland, H. Y., Canale, A., Louis, T., Stuhr, L. E. B., Sounni, N. E., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125890 · Cited by 148 · see citing works
The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited
Dzobo, K., Senthebane, D. A., & Dandara, C. (2023) · Cancers · doi:10.3390/cancers15020376 · Cited by 146 · see citing works
The harsh microenvironment in early breast cancer selects for a Warburg phenotype
Damaghi, M., West, J., Robertson‐Tessi, M., Xu, L., Ferrall‐Fairbanks, M. C., Stewart, P. A., Persi, E., Fridley, B. L., Altrock, P. M., Gatenby, R. A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011342118 · Cited by 143 · see citing works
Saha, T., & Lukong, K. E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.856974 · Cited by 147 · see citing works
Gu, X., Zhu, Y., Su, J., Wang, S., Su, X., Ding, X., Jiang, L., Fei, X., & Zhang, W. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103209 · Cited by 127 · see citing works
Wong, H. Y., Sheng, Q., Hesterberg, A. B., Croessmann, S., Rios, B. L., Giri, K. R., Jackson, J., Miranda, A. X., Watkins, E., Schaffer, K. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33780-1 · Cited by 124 · see citing works
Xiang, X., Niu, Y., Wang, Z.-H., Ye, L., Peng, W., & Zhou, Q. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.006 · Cited by 120 · see citing works
Jurj, A. M., Ionescu, C., Berindan‐Neagoe, I., & Braicu, C. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02484-1 · Cited by 109 · see citing works
Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging
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Xiu, M., Liu, Y., & Kuang, B. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110416 · Cited by 93 · see citing works
Duan, M., Liu, H., Xu, S., Yang, Z., Zhang, F., Wang, G., Wang, Y., Zhao, S., & Jiang, X. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.017 · Cited by 88 · see citing works
Chen, P., Wei, W.-F., Wu, H.-Z., Fan, L., & Wang, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.671595 · Cited by 78 · see citing works
Xue, B., Chuang, C.-H., Prosser, H. M., Fuziwara, C. S., Chan, C., Sahasrabudhe, N. S., Kühn, M., Wu, Y., Chen, J., Biton, A., et al. (2021) · Genes & Development · doi:10.1101/gad.347344.120 · Cited by 73 · see citing works
A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer
Bonneau, C., Eliès, A., Kieffer, Y., Bourachot, B., Ladoire, S., Pelon, F., Héquet, D., Guinebretière, J. M., Blanchet, C., Vincent‐Salomon, A., et al. (2020) · Breast Cancer Research · doi:10.1186/s13058-020-01311-9 · Cited by 70 · see citing works
Mezheyeuski, A., Segersten, U., Leiss, L. W., Malmström, P., Hatina, J., Östman, A., & Strell, C. (2020) · Scientific Reports · doi:10.1038/s41598-019-55013-0 · Cited by 69 · see citing works
Self-citationCancer associated fibroblasts: role in breast cancer and potential as therapeutic targets
Lappano, R., Rigiracciolo, D. C., Belfiore, A., Maggiolini, M., & Francesco, E. M. D. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1751819 · Cited by 69 · see citing works
Cancer-Associated Fibroblasts and T Cells: From Mechanisms to Outcomes
Baker, A. T., Abuwarwar, M. H., Poly, L., Wilkins, S., & Fletcher, A. L. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001203 · Cited by 68 · see citing works
Micke, P., Strell, C., Mattsson, J. S. M., Martín-Bernabé, A., Brunnström, H., Huvila, J. K., Sund, M., Wärnberg, F., Pontén, F., Glimelius, B. L. G., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103269 · Cited by 65 · see citing works
Self-citationNedaeinia, R., Najafgholian, S., Salehi, R., Goli, M., Ranjbar, M., Nickho, H., Javanmard, S. H., Ferns, G. A., & Manian, M. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02146-5 · Cited by 65 · see citing works
Yu, S., Wang, S., Wang, X., & Xu, X. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03518-8 · Cited by 65 · see citing works
Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the Spotlight
Cortesi, M., Zanoni, M., Pirini, F., Tumedei, M. M., Ravaioli, S., Rapposelli, I. G., Frassineti, G. L., & Bravaccini, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010254 · Cited by 60 · see citing works
Roles of Notch Signaling in the Tumor Microenvironment
D’Assoro, A. B., Leon-Ferre, R. A., Braune, E.-B., & Lendahl, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116241 · Cited by 62 · see citing works
Self-citationVenning, F. A., Zornhagen, K. W., Wullkopf, L., Sjölund, J., Rodriguez-Cupello, C., Kjellman, P., Morsing, M., Hajkarim, M. C., Won, K., Erler, J. T., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01944-4 · Cited by 58 · see citing works
The role of Hedgehog and Notch signaling pathway in cancer
Xia, R., Xu, M., Yang, J., & Ma, X. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00099-8 · Cited by 57 · see citing works
Notch signaling in cancer: Complexity and challenges on the path to clinical translation
Ferreira, A. P. A., & Aster, J. C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.008 · Cited by 55 · see citing works
Owen, J. S., Clayton, A., & Pearson, H. B. (2022) · Biomolecules · doi:10.3390/biom13010067 · Cited by 57 · see citing works
Gao, D., Fang, L., Liu, C., Yang, M., Yu, X., Wang, L., Zhang, W., Sun, C., & Zhuang, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115622 · Cited by 53 · see citing works
Qadir, J., Wen, S.-Y., Yuan, H., & Yang, B. B. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.12.005 · Cited by 51 · see citing works
Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective
Gentric, G., & Mechta‐Grigoriou, F. (2021) · Cancers · doi:10.3390/cancers13030399 · Cited by 50 · see citing works
Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
Elwakeel, E., & Weigert, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111636 · Cited by 48 · see citing works
Zou, R., Jiang, Q., Jin, T., Chen, M., Yao, L., & Ding, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.956224 · Cited by 44 · see citing works
A review concerning the breast cancer-related tumour microenvironment
Rodríguez-Bejarano, O. H., Parra-López, C., & Patarroyo, M. A. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104389 · Cited by 41 · see citing works
Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
Mancini, S. J. C., Balabanian, K., Corre, I., Gavard, J., Lazennec, G., Bousse‐Kerdilès, M. L., Louache, F., Maguer‐Satta, V., Mazure, N. M., Mechta‐Grigoriou, F., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766275 · Cited by 41 · see citing works
The role of cancer-associated fibroblasts in breast cancer metastasis
Li, Y., Wang, C., Huang, T. H., Yu, X., & Tian, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1194835 · Cited by 40 · see citing works
Magagna, I., Gourdin, N., Kieffer, Y., Licaj, M., Mhaidly, R., André, P., Morel, A., Vincent‐Salomon, A., Paturel, C., & Mechta‐Grigoriou, F. (2021) · Cancers · doi:10.3390/cancers13235878 · Cited by 40 · see citing works
Tan, K., & Naylor, M. J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.876451 · Cited by 38 · see citing works
Meng, Q., Luo, X., Chen, J., Wang, D., Chen, E., Zhang, W., Zhang, G., Zhou, W., Xu, J., & Song, Z. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188443 · Cited by 38 · see citing works
Dual Role of Fibroblasts Educated by Tumour in Cancer Behavior and Therapeutic Perspectives
Toledo, B., Picon‐Ruiz, M., Marchal, J. A., & Perán, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415576 · Cited by 39 · see citing works
Huang, J., Tsang, W. Y., Li, Z., & Guan, X. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.07.001 · Cited by 40 · see citing works
Zhang, X., Zhu, R., Yu, D., Wang, J., Yan, Y., & Xu, K. (2023) · Cell Proliferation · doi:10.1111/cpr.13592 · Cited by 34 · see citing works
Elwakeel, E., Brüggemann, M., Wagih, J., Lityagina, O., Elewa, M. A. F., Han, Y., Frömel, T., Popp, R., Nicolas, A. M., Schreiber, Y., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2116 · Cited by 32 · see citing works
CD36 and CD97 in Pancreatic Cancer versus Other Malignancies
Tănase, C., Gheorghișan-Gălățeanu, A.-A., Popescu, I. D., Mihai, S., Codrici, E., Albulescu, R., & Hinescu, M. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165656 · Cited by 32 · see citing works
Everybody needs good neighbours: the progressive DCIS microenvironment
Gibson, S. V., Roozitalab, R., Allen, M. D., Jones, J. L., Carter, E. P., & Grose, R. P. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.01.002 · Cited by 31 · see citing works
Functional and clinical roles of stromal PDGF receptors in tumor biology
Strell, C., Rodríguez‐Tomàs, E., & Östman, A. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10194-7 · Cited by 31 · see citing works
Self-citationTumour stroma ratio is a potential predictor for 5-year disease-free survival in breast cancer
Yan, D., Ju, X., Luo, B., Guan, F., He, H., Yan, H., & Yuan, J. (2022) · BMC Cancer · doi:10.1186/s12885-022-10183-5 · Cited by 30 · see citing works
Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
Kilvaer, T. K., Rakaee, M., Hellevik, T., Vik, J., Petris, L. D., Dønnem, T., Strell, C., Östman, A., Busund, L., & Martínez-Zubiaurre, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-46510-3 · Cited by 30 · see citing works
Self-citationMolecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer
Plundrich, D., Chikhladze, S., Fichtner‐Feigl, S., Feuerstein, R., & Briquez, P. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052782 · Cited by 31 · see citing works
Microfluidic-based human prostate-cancer-on-chip
Jiang, L., Khawaja, H., Tahsin, S., Clarkson, T. A., Miranti, C. K., & Zohar, Y. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1302223 · Cited by 26 · see citing works
Unlocking antitumor immunity with adenosine receptor blockers
Remley, V. A., Linden, J. M., Bauer, T. W., & Dimastromatteo, J. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2023.63 · Cited by 26 · see citing works
Trnkova, L., Buociková, V., Mego, M., Čumová, A., Buríková, M., Boháč, M., Miklikova, S., Cihova, M., & Smolková, B. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116559 · Cited by 28 · see citing works
Musa, M., & Ali, A. (2020) · Future Oncology · doi:10.2217/fon-2020-0384 · Cited by 25 · see citing works
Schiza, A., Thurfjell, V., Tullberg, A. S., Olofsson, H., Lindberg, A., Holmberg, E. C., Bremer, T. M., Micke, P., Karlsson, P., Wärnberg, F., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.01.016 · Cited by 23 · see citing works
Self-citationStrell, C., Tullberg, A. S., Edelmann, R. J., Akslen, L. A., Malmström, P., Fernö, M., Holmberg, E. C., Östman, A., & Karlsson, P. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06136-4 · Cited by 22 · see citing works
Self-citationExtracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment
Samuels, M., Cilibrasi, C., Papanastasopoulos, P., & Giamas, G. (2022) · Biomolecules · doi:10.3390/biom12010132 · Cited by 21 · see citing works
Cancer-associated fibroblasts in carcinogenesis
Zhou, S., Zhao, Z., Wang, Z., Xu, H., Li, Y., Xu, K., Li, W., & Yang, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06071-8 · Cited by 21 · see citing works
Cancer-Associated Fibroblast Heterogeneity in Malignancy with Focus on Oral Squamous Cell Carcinoma
Arebro, J., Lee, C.-M., Bennewith, K. L., & Garnis, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021300 · Cited by 21 · see citing works
Fibroblasts in cancer: Defining target structures for therapeutic intervention
Boesch, M., Baty, F., Rumpold, H. F., Sopper, S., Wolf, D. G. F., & Brutsche, M. H. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.06.003 · Cited by 20 · see citing works
Phenotype transition of fibroblasts incorporated into patient‐derived oral carcinoma organoids
Chen, X., Li, R., Zhao, H., Wang, X., Shao, Z., & Shang, Z. (2021) · Oral Diseases · doi:10.1111/odi.14071 · Cited by 19 · see citing works
Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
Kakarla, M., ChallaSivaKanaka, S., Dufficy, M. F., Gil, V., Filipovich, Y., Vickman, R. E., Crawford, S. E., Hayward, S. W., & Franco, O. E. (2022) · Cancers · doi:10.3390/cancers14092336 · Cited by 19 · see citing works
Ahn, S., Kwon, A., Huh, Y. H., Rhee, S., & Song, W. K. (2022) · Oncogenesis · doi:10.1038/s41389-022-00422-6 · Cited by 19 · see citing works
Xue, C., Gao, Y., Sun, Z., Li, X., Zhang, M., Yang, Y., Han, Q., Bai, C., & Zhao, R. C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.837781 · Cited by 18 · see citing works
Burley, A., Rullan, A., & Wilkins, A. C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1000888 · Cited by 18 · see citing works
Single cell imaging-based chromatin biomarkers for tumor progression
Venkatachalapathy, S., Jokhun, D. S., Andhari, M. D., & Shivashankar, G. V. (2021) · Scientific Reports · doi:10.1038/s41598-021-02441-6 · Cited by 17 · see citing works
Role of autophagy in cancer-associated fibroblast activation, signaling and metabolic reprograming
Sari, D., Gözüaçık, D., & Akkoç, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1274682 · Cited by 17 · see citing works
Zhang, Z., & Wu, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1641518 · Cited by 16 · see citing works
Magoulopoulou, A., Qian, X., Setiabudiawan, T. P., Salas, S. M., Yokota, C., Rottenberg, M. E., Nilsson, M. F., & Carow, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.876321 · Cited by 15 · see citing works
Self-citationHulahan, T. S., & Angel, P. M. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03236-z · Cited by 16 · see citing works
Expression of PD-L1 on Monocytes Is a Novel Predictor of Prognosis in Natural Killer/T-Cell Lymphoma
Zhang, X., Bi, X., Liu, P., Liu, Z.-L., Nie, M., Yang, H., Lei, D., Xia, Y., Jiang, W., & Zeng, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01360 · Cited by 16 · see citing works
Strell, C., Folkvaljon, D., Holmberg, E. C., Schiza, A., Thurfjell, V., Karlsson, P., Bergh, J. C. S., Bremer, T. M., Akslen, L. A., Wärnberg, F., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4300 · Cited by 16 · see citing works
Self-citationIdentifying recurrences and metastasis after ductal carcinoma in situ ( DCIS ) of the breast
Udayasiri, R. I., Luo, T., Gorringe, K. L., & Fox, S. B. (2022) · Histopathology · doi:10.1111/his.14804 · Cited by 16 · see citing works
Wu, D., Wang, S., Oliveira, D. V., Gaudio, F. D., Vanlandewijck, M., Lebouvier, T., Betsholtz, C., Zhao, J., Jin, S., Lendahl, U., et al. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.046300 · Cited by 16 · see citing works
Self-citationYamaguchi, H., & Miyazaki, M. (2024) · Cancers · doi:10.3390/cancers16091636 · Cited by 15 · see citing works
Cancer-associated fibroblasts: heterogeneity and their role in the tumor immune response
Xiao, Y., Wang, Z., Gu, M., Wei, P., Wang, X., & Li, W. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01375-3 · Cited by 15 · see citing works
Lian, W., Xiang, P., Ye, C., & Xiong, J. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673282799231211113347 · Cited by 14 · see citing works
A Simple Framework for Agent-Based Modeling with Extracellular Matrix
Metzcar, J., Duggan, B. S., Fischer, B., Murphy, M., Heiland, R. W., & Macklin, P. (2025) · Bulletin of Mathematical Biology · doi:10.1007/s11538-024-01408-8 · Cited by 14 · see citing works
Metastasis and cancer associated fibroblasts: taking it up a NOTCH
Ghosh, A., & Mitra, A. K. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1277076 · Cited by 12 · see citing works
Fouillet, J., Torchio, J., Rubira, L., & Fersing, C. (2024) · Biology · doi:10.3390/biology13120967 · Cited by 12 · see citing works
Noh, K. H., Jeong, A. J., Lee, H., Lee, S. H., Yi, E. S., Chang, P., Kwak, C. H., & Ye, S. K. (2020) · Cancers · doi:10.3390/cancers12051083 · Cited by 12 · see citing works
Cui, M., Dong, H., Duan, W., Wang, X., Liu, Y., Shi, L., & Zhang, B. (2024) · PeerJ · doi:10.7717/peerj.16958 · Cited by 11 · see citing works
A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation
Mega, A., Mebrahtu, A., Aniander, G., Ryer, E., Sköld, A. E., Sandegren, A., Rydin, E. B., Rockberg, J., Östman, A., & Frejd, F. Y. (2023) · mAbs · doi:10.1080/19420862.2023.2223750 · Cited by 11 · see citing works
Self-citationChoi, J., Kwak, Y., Park, M., Jo, J. Y., Kang, J. H., Kook, M., Kim, H., Kim, G., Kong, S., Park, D. J., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01447-8 · Cited by 10 · see citing works
Cell-cell interactions that drive tumorigenesis in Drosophila
Enomoto, M., & Igaki, T. (2022) · Fly · doi:10.1080/19336934.2022.2148828 · Cited by 9 · see citing works
Devarasou, S., Kang, M., Kwon, T. Y., Cho, Y., & Shin, J. H. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00694 · Cited by 10 · see citing works
Thennavan, A., García‐Recio, S., Liu, S., He, X., & Perou, C. M. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00450-w · Cited by 9 · see citing works
TGF-β controls stromal telomere length through epigenetic modifications
Mishra, R., Haldar, S., Biondi, S., Bhari, V. K., Singh, G., & Bhowmick, N. A. (2022) · 3 Biotech · doi:10.1007/s13205-022-03346-5 · Cited by 9 · see citing works
The role of cancer‐associated fibroblasts in the tumour microenvironment of urinary system
Hong, R., Yu, P., Zhang, X., Su, P. C., Liang, H., Dong, D. F., Wang, X., & Wang, K. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70299 · Cited by 8 · see citing works
Identification of a Notch transcriptomic signature for breast cancer
Braune, E.-B., Geist, F., Tang, X., Kalari, K. R., Boughey, J. C., Wang, L., Leon-Ferre, R. A., D’Assoro, A. B., Ingle, J. N., Goetz, M. P., et al. (2024) · Breast Cancer Research · doi:10.1186/s13058-023-01757-7 · Cited by 8 · see citing works
Self-citationJagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer
Parikainen, M., Suwal, U., Rappu, P., Heino, J., & Sahlgren, C. (2026) · Science Advances · doi:10.1126/sciadv.aea9562 · Cited by 10 · see citing works
- Authors
- Strell, C., Paulsson, J., Jin, S.-B., Tobin, N. P., Mezheyeuski, A., Roswall, P., Mutgan, C., Mitsios, N., Johansson, H., Wickberg, S. M., Svedlund, J., Nilsson, M., Hall, P., Mulder, J., Radisky, D. C., Pietras, K., Bergh, J., Lendahl, U., Wärnberg, F., & Östman, A.
- Affiliations
- Stockholm University (SE)
- Karolinska Institutet (SE)
- Lund University (SE)
- Uppsala University (SE)
- Mayo Clinic in Florida (US)
- Corresponding author
- Strell, Carina
- ORCID
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-02-28
- Volume
- 111
- Issue
- 9
- Pages
- 983-995
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- PMC
- PMC6748730
- OpenAlex
- W2920295895
- Cited by
- 158
- References
- 59
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 25 · 2023: 19 · 2022: 36 · 2021: 30 · 2020: 19 · 2019: 4
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Swedish Cancer Society (150895)
- Swedish Research Council (349–2006-160)
- Radiumhemmets forskningsfonder, EU Caffein ITN network (3047/12)
- BRECT network of Karolinska Institutet
- Stockholm County Council
- Comprehensive Cancer Consortium
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- ductal carcinoma in situ, stromal-epithelial interactions, PDGFR, PDGFRA, PDGFRβ, fibroblast phenotype, local recurrence, JAG1, Notch2, juxtacrine signaling, prognostic factors, breast cancer
- MeSH terms
- Cancer-Associated Fibroblasts, Adult, Aged, Aged, 80 and over, Animals, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Cell Communication, Disease Models, Animal, Epithelial Cells, Female, Humans, Immunohistochemistry, Middle Aged, Prognosis, Biomarkers, Tumor, Stromal Cells, Receptors, Platelet-Derived Growth Factor, Coculture Techniques, Computational Biology, Gene Expression Profiling, Cell Line, Tumor, Mice, Neoplasm Grading
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