Differences in cognitive impairment in primary age-related tauopathy versus Alzheimer disease
Open accessAbstract
This study examined differences in neuropsychological test scores between individuals with primary age-related tauopathy (PART) and Alzheimer disease (AD) using cross-sectional data from the National Alzheimer's Coordinating Center. Linear regression tested for differences in 4 cognitive domains stratified by cognitive status (global Clinical Dementia Rating [CDR]). The sample included 240 participants with no neuritic plaques (NP) (definite PART), 186 with sparse NP (possible PART), and 510 with moderate/frequent NP (AD). Four cognitive domain z-score outcome variables (memory, attention, executive function, and semantic memory/language) were calculated using 12 neuropsychological tests. Definite PART participants had a sparing of semantic memory/language compared to those with AD, with a mean adjusted z-score difference of 0.37 (95% confidence interval [CI]: 0.16-0.58) for those with CDR = 0.5 or 1 and of 0.92 (CI: 0.22-1.63) for those with CDR = 2 or 3. Compared to participants with AD, definite PART participants with CDR = 0.5 or 1 had sparing of memory (adjusted z-score difference: 0.61; CI: 0.39-0.84) and definite PART participants with CDR = 2 or 3 had sparing of attention (adjusted z-score difference: 0.76: CI: 0.09-1.43). Patterns of cognitive impairment differed between definite PART and AD, suggesting significant differences in clinical presentation between individuals from these 2 groups.
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AD-Mimics and definite PART are both defined as having no neuritic plaques, and PART participants are generally older and experience less severe cognitive dysfunction.
“AD-Mimics and definite PART are both defined as having no neuritic plaques, and like the AD-Mimics in this study, PART participants are generally older and experience less severe cognitive dysfunction (22,23).”
From Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy (2020) · cites this paper as [23]
The Participants section defines definite PART as having no neuritic plaques, and the Results and Discussion report less severe cognitive impairment in PART than in AD. The Discussion describes PART as typically affecting older people, but says the age distribution was similar for definite PART and AD. This paper does not address the definition of AD-Mimics, so it does not support that part of the jointly cited sentence. (LLM, conf=0.86)
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Self-citation
- Authors
- Besser, L. M., Mock, C., Teylan, M. A., Hassenstab, J., Kukull, W. A., & Crary, J. F.
- Affiliations
- Florida Atlantic University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Besser, Lilah M
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-02-01
- Volume
- 78
- Issue
- 3
- Pages
- 219-228
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- PMC
- PMC6380319
- OpenAlex
- W2913901142
- Cited by
- 45
- References
- 23
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 5
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIA (P30 AG019610, P30 AG013846, P50 AG008702, P50 AG025688, P50 AG047266)
- NIH (U01 AG016976)
- National Institutes of Health (R01 NS095252, R01 AG054008, RF1 AG06096, R01 AG062348)
- Alzheimer’s Association (NIRG-15-363188)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- primary age-related tauopathy, Alzheimer's disease, cognitive impairment, semantic memory, language, memory, attention, executive function, Clinical Dementia Rating, neuritic plaques, neuropsychological test scores, differential diagnosis
- MeSH terms
- Mental Status and Dementia Tests, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Tauopathies, Cognitive Dysfunction
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