The Revised National Alzheimer’s Coordinating Center’s Neuropathology Form—Available Data and New Analyses
Open accessAbstract
Neuropathologic evaluation remains the gold standard for determining the presence and severity of aging-related neurodegenerative diseases. Researchers at U.S. Alzheimer's Disease Centers (ADCs) have worked for >30 years studying human brains, with the goals of achieving new research breakthroughs. Harmonization and sharing among the 39 current and past ADCs is promoted by the National Alzheimer's Coordinating Center (NACC), which collects, audits, and disburses ADC-derived data to investigators on request. The past decades have witnessed revised disease definitions paired with dramatic expansion in the granularity and multimodality of the collected data. The NACC database now includes cognitive test scores, comorbidities, drug history, neuroimaging, and links to genomics. Relatively, recent advances in the neuropathologic diagnoses of Alzheimer's disease, frontotemporal lobar degeneration (FTLD), and vascular contributions to cognitive impairment and dementia catalyzed a 2014 update to the NACC Neuropathology Form completed by all ADCs. New focal points include cerebrovascular disease (including arteriolosclerosis, microbleeds, and microinfarcts), hippocampal sclerosis, TDP-43, and FTLD. Here, we provide summary data and analyses to illustrate the potential for both hypothesis-testing and also generating new hypotheses using the NACC Neuropathology data set, which represents one of the largest multi-center databases of carefully curated neuropathologic information that is freely available to researchers worldwide.
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Neuropathologic evaluations are considered the gold standard for confirming the presence and severity of neurodegenerative diseases.
“Neuropathologic evaluations are considered to be the gold standard for confirming the presence and severity of neurodegenerative diseases50.”
From Multimodal deep learning for Alzheimer's disease dementia assessment (2022) · cites this paper as [50]
The Abstract calls neuropathologic evaluation the gold standard for determining the presence and severity of aging-related neurodegenerative diseases. The citing sentence omits “aging-related,” extending the statement beyond the scope specified in the source. (LLM, conf=0.85)
Experimental — accuracy not yet measuredA study comparing neuropathological features at autopsy by year of death in NACC showed that presence of microinfarcts has been consistent over time, with 18% from 2002-2011, 19.2% from 2012-2013, and 23.9% from 2014-2018.
“A study comparing neuropathological features at autopsy by year of death in the NACC database showed that the presence of microinfarcts has been consistent over time, with 18% of participants having microinfarcts from 2002 to 2011, 19.2% from 2012 to 2013 and 23.9% from 2014 to 2018 (24).”
From Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy (2020) · cites this paper as [24]
Table 3 (reproduced in the Discussion) reports the cited microinfarct percentages: 18.0%, 19.2%, and 23.9%. But the paper describes microinfarcts as becoming more commonly diagnosed, not remaining consistent over time. Its final study period ends in 2017, not 2018. (LLM, conf=0.90)
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- Authors
- Besser, L. M., Kukull, W. A., Teylan, M. A., Bigio, E. H., Cairns, N. J., Kofler, J. K., Montine, T. J., Schneider, J. A., & Nelson, P. T.
- Affiliations
- University of Washington (US)
- Northwestern University (US)
- Washington University in St. Louis (US)
- University of Pittsburgh (US)
- Stanford Medicine (US)
- Rush University (US)
- University of Kentucky (US)
- Corresponding author
- Besser, Lilah M
- ORCID
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-06-25
- Volume
- 77
- Issue
- 8
- Pages
- 717-726
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- PMC
- PMC6044344
- OpenAlex
- W2810908760
- Cited by
- 224
- References
- 46
- Citations by year
- 2026: 31 · 2025: 49 · 2024: 39 · 2023: 27 · 2022: 27 · 2021: 19 · 2020: 18 · 2019: 11 · 2018: 2 · 2012: 1
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIA
- NIH (U01 AG016976, P01 AG003991, P30 AG028383, P30 AG013854, AG047366, P50 AG005133, P50 AG005681)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, frontotemporal lobar degeneration, cerebrovascular disease, arteriolosclerosis, cerebral microbleeds, cerebral microinfarcts, hippocampal sclerosis, TDP-43
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cross-Sectional Studies, Data Interpretation, Statistical, Female, Humans, Male, Cohort Studies, Databases, Factual
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