Cited by 156Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceSalmonella and Campylobacter epidemiology

Systematic review of antibiotic resistance rates among Gram-negative bacteria in children with sepsis in resource-limited countries

Le Doare, Kirsty, Bielicki, Julia, Heath, Paul T., Sharland, Mike·2015·Journal of the Pediatric Infectious Diseases Society

Abstract

BACKGROUND: Gram-negative antimicrobial resistance (AMR) is of global concern, yet there are few reports from low- and low-middle-income countries, where antimicrobial choices are often limited. METHODS: This study offers a systematic review of PubMed, Embase, and World Health Organization (WHO) regional databases of Gram-negative bacteremia in children in low- and low-middle-income countries reporting AMR since 2001. RESULTS: Data included 30 studies comprising 71 326 children, of whom 7056 had positive blood cultures, and Gram-negative organisms were isolated in 4710 (66.8%). In neonates, Klebsiella pneumoniae median resistance to ampicillin was 94% and cephalosporins 84% in Asia; 100% and 50% in Africa. Large regional variations in resistance rates to commonly prescribed antibiotics for Salmonella spp. were identified. Multidrug resistance (resistance to ampicillin, chloramphenicol, and cotrimoxazole) was present in 30% (interquartile range [IQR], 0-59.6) in Asia and 75% (IQR, 30-85.4) in Africa. CONCLUSIONS: There is a need for an international pediatric antimicrobial resistance surveillance system that collects local epidemiological data to improve the evidence base for the WHO guidance for childhood Gram-negative bacteremia.

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Crossref · 10.1093/jpids/piu014

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Authors
Le Doare, K., Bielicki, J., Heath, P. T., & Sharland, M.
Affiliations
St George's, University of London (GB)
Venue
Journal of the Pediatric Infectious Diseases Society
Published
2014-03-24
Volume
4
Issue
1
Pages
11-20
ISSN
  • 2048-7193 (ISSN-L)
  • 2048-7207
OpenAlex
W2100694940
Cited by
156
References
56
Citations by year
2026: 7 · 2025: 14 · 2024: 18 · 2023: 14 · 2022: 11 · 2021: 23 · 2020: 13 · 2019: 18 · 2018: 12 · 2017: 18 · 2016: 2 · 2015: 4 · 2014: 2
FWCI
0.58
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Pediatric Infectious Diseases Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords
antimicrobial resistance, Gram-negative bacteria, pediatric sepsis, bacteremia, low- and middle-income countries, Klebsiella pneumoniae, Salmonella, multidrug resistance, ampicillin resistance, cephalosporin resistance, chloramphenicol resistance, trimethoprim-sulfamethoxazole resistance, antimicrobial resistance surveillance, neonates
MeSH terms
Africa, Anti-Bacterial Agents, Asia, Child, Developing Countries, Gram-Negative Bacteria, Humans, Poverty, Gram-Negative Bacterial Infections, Sepsis, Drug Resistance, Bacterial

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