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Cited by 13Mental Health and PsychiatryNeuroscience and Neuropharmacology ResearchTreatment of Major Depression

The DOI matches its Crossref record.

Charney & Nestler's Neurobiology of Mental Illness

·2017
DOI 10.1093/med/9780190681425.001.0001
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Abstract

In the years following publication of the DSM-5, the field of psychiatry has seen vigorous debate between the DSM’s more traditional, diagnosis-oriented approach and the NIMH’s more biological, dimension-based RDoC approach. Charney & Nestler’s Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and this edition extends beyond its reference function to acknowledge and examine the controversies and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Section I, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect important technical advances in complex genetics, epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. These established and emerging methodologies offer groundbreaking advances in our ability to study the brain and breakthroughs in our therapeutic toolkit. Sections II through VII cover the neurobiology and genetics of major psychiatric disorders: psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. The last section, Section VIII, focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5 and RDoC. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

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Crossref · 10.1093/med/9780190681425.001.0001

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  • Oxytocin, serotonin, and dopamine play pivotal roles in regulating prosocial behaviors such as social approach.

    “In addition to OXT being a critical regulator of affiliative social behavior, it became apparent that the prominent neuromodulators, serotonin (5-HT) and dopamine (DA), which are implicated in a variety of cognitive and emotional processes [3,12,[14][15][16][17], also play pivotal roles in regulating prosocial behaviors such as social approach [3,18].”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [3]

  • Impairments in adaptive, prosocial behaviors commonly occur in a broad range of neuropsychiatric disorders including schizophrenia, substance use disorder, mood disorders, and autism spectrum disorder.

    “Impairments in prosocial behaviors, which occur in a large number of neuropsychiatric disorders, result from disruption of the coordinated activity of these neural circuits.”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [3]

  • Serotonin release in the central nervous system has been implicated in regulating a broad range of behaviors, including sociability.

    “For decades, 5-HT release in the central nervous system has been implicated in regulating a broad range of behaviors, including sociability [3,18,[44][45][46].”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [3]

  • Impairments in adaptive prosocial behaviors are present in many brain disorders including ASD, SZ, substance use disorder and depression.

    “Impairments in adaptive prosocial behaviors are present in many brain disorders including ASD, SZ, substance use disorder and depression [3,117].”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [3]

  • Standard treatments such as SSRIs or SNRIs, when effective in treating depression, likely ameliorate sociability deficits, but are commonly ineffective in treating large proportions of subjects with mood disorders.

    “It is likely that when effective in treating depression, standard treatments such as selective 5-HT reuptake inhibitors (SSRIs) or 5-HT and norepinephrine reuptake inhibitors (SNRIs) ameliorate sociability deficits but these are all too commonly ineffective in treating large proportions of subjects with mood disorders [3,170,171].”

    From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [3]

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Metadata

Publisher
Oxford University PressNew York
Published
2017-11
DOI
10.1093/med/9780190681425.001.0001
OpenAlex
W4249871951
Cited by
13
References
0
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2018: 1
FWCI
1.16
Type
book
Language
en
Open access
closed
Topics
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
neurobiology of mental disorders, psychiatric diagnosis, DSM-5, psychiatric genetics, epigenetics, stem cell biology, optogenetics, neural circuits, psychosis, mood disorders, anxiety disorders, substance use disorders, dementia, childhood-onset disorders, precision psychiatry, computational psychiatry, neuropharmacology, neuroimaging

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