5-HT release in nucleus accumbens rescues social deficits in mouse autism model
Open accessAbstract
Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5-HT) from dorsal raphe neurons in the nucleus accumbens bidirectionally modifies sociability. In a mouse model of a common genetic cause of autism spectrum disorder-a copy number variation on chromosome 16p11.2-genetic deletion of the syntenic region from 5-HT neurons induces deficits in social behaviour and decreases dorsal raphe 5-HT neuronal activity. These sociability deficits can be rescued by optogenetic activation of dorsal raphe 5-HT neurons, an effect requiring and mimicked by activation of 5-HT1b receptors in the nucleus accumbens. These results demonstrate an unexpected role for 5-HT action in the nucleus accumbens in social behaviours, and suggest that targeting this mechanism may prove therapeutically beneficial.
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Optogenetic activation of dorsal raphe serotonin inputs in the nucleus accumbens increased sociability while optogenetic inhibition decreased sociability, as measured by juvenile interaction and three-chamber sociability assays.
“Work utilizing a circuit-based approach to examine the role of 5-HT release from DR inputs in the NAc revealed that optogenetic activation of DR 5-HT inputs increased sociability while optogenetic inhibition of these inputs decreased sociability, as measured by the juvenile interaction and three-chamber sociability assays [47].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
Pharmacological blockade of 5-HT1b receptors in the nucleus accumbens via local infusion of a selective antagonist prevented the enhanced sociability due to activation of dorsal raphe serotonin neurons.
“Furthermore, pharmacological blockade of 5-HT1b receptors in the NAc via local infusion of a selective antagonist prevented the enhanced sociability due to activation of DR 5-HT neurons [47].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
Unlike dopamine release in the nucleus accumbens caused by optogenetic stimulation or administration of drugs of abuse, serotonin release in the nucleus accumbens is not acutely reinforcing.
“Importantly, unlike the release of DA in the NAc caused by optogenetic stimulation or administration of drugs of abuse [11,21,53,54], 5-HT release in the NAc is not acutely reinforcing [11,21,47] but see ref. [55].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
The sociability deficits in the 16p11.2 deletion model were associated with reduction in intrinsic excitability of DR 5-HT neurons.
“and reduction in their intrinsic excitability [47].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
Optogenetic activation of DR 5-HT inputs in the NAc rescued the social deficits in the 16p11.2 deletion mice.
“Optogenetic activation of DR 5-HT inputs in the NAc rescued the social deficits present in these mice”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
The sociability deficits in the 16p11.2 deletion model were associated with decreases in DR 5-HT neuron activity during social encounters.
“which was associated with decreases in DR 5-HT neuron activity during social encounters”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
The rescue of social deficits by optogenetic activation of DR 5-HT inputs in NAc was dependent upon activation of presynaptic 5-HT1b receptors.
“this rescue was dependent upon activation of presynaptic 5-HT1b receptors [47].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
In a 16p11.2 deletion mouse model, selective deletion of the syntenic chromosomal region specifically in DR 5-HT neurons induced deficits in sociability.
“In a 16p11.2deletion mouse model, selective deletion of the syntenic chromosomal region specifically in DR 5-HT neurons induced deficits in sociability”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [47]
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Cites
Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415 · see citing works
The social motivation theory of autism
Chevallier, C., Kohls, G., Troiani, V., Brodkin, E. S., & Schultz, R. T. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.02.007 · Cited by 2,072 · see citing works
Christensen, D. L., Baio, J., Braun, K. V. N., Bilder, D., Charles, J., Constantino, J. N., Daniels, J., Durkin, M. S., Fitzgerald, R. T., Kurzius-Spencer, M., et al. (2016) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss6503a1 · Cited by 1,964 · see citing works
Association between Microdeletion and Microduplication at 16p11.2 and Autism
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M. A. R., Green, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa075974 · Cited by 1,666 · see citing works
Natural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389 · see citing works
Self-citationInput-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300 · see citing works
Self-citationPhasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266 · see citing works
Self-citationSanders, S. J., Ercan-Sencicek, A. G., Hus, V., Luo, R., Murtha, M. T., Moreno-De-Luca, D., Chu, S. H., Moreau, M. P., Gupta, A. R., Thomson, S. A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.002 · Cited by 1,263 · see citing works
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161 · see citing works
Self-citationDopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977 · see citing works
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works
Self-citationThe human raphe nuclei and the serotonergic system
Hornung, J.-P. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.002 · Cited by 742 · see citing works
Recurrent 16p11.2 microdeletions in autism
Kumar, R. A., KaraMohamed, S., Sudi, J., Conrad, D. F., Brune, C., Badner, J. A., Gilliam, T. C., Nowak, N. J., Cook, E. H., Dobyns, W. B., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm376 · Cited by 731 · see citing works
Grimm, D., Lee, J. S., Wang, L., Desai, T., Akache, B., Storm, T. A., & Kay, M. A. (2008) · Journal of Virology · doi:10.1128/jvi.00254-08 · Cited by 696 · see citing works
Association Between Microdeletion and Microduplication at 16p11.2 and Autism
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Sæmundsen, E., Stefánsson, H., Ferreira, M. A. R., Green, T. J., et al. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000316305.61461.6f · Cited by 647 · see citing works
A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge
Warden, M. R., Selimbeyoglu, A., Mirzabekov, J. J., Lo, M., Thompson, K. R., Kim, S.-Y., Adhikari, A., Tye, K. M., Frank, L. M., & Deisseroth, K. (2012) · Nature · doi:10.1038/nature11617 · Cited by 645 · see citing works
Self-citationStudies on 5-hydroxyindole metabolism in autistic and other mentally retarded children
Schain, R. J., & Freedman, D. X. (1961) · The Journal of Pediatrics · doi:10.1016/s0022-3476(61)80261-8 · Cited by 579 · see citing works
Assessment of Social Interaction Behaviors
Kaidanovich‐Beilin, O., Lipina, T. V., Vukobradovic, I., Roder, J., & Woodgett, J. R. (2011) · Journal of Visualized Experiments · doi:10.3791/2473 · Cited by 550 · see citing works
The serotonin system in autism spectrum disorder: From biomarker to animal models
Muller, C. L., Anacker, A. M. J., & Veenstra-VanderWeele, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.010 · Cited by 531 · see citing works
Dorsal raphe neurons signal reward through 5-HT and glutamate
Liu, Z., Zhou, J., Li, Y., Hu, F., Lu, Y., Ma, M., Feng, Q., Zhang, J.-E., Wang, D., Zeng, J., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.010 · Cited by 469 · see citing works
Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala
Marcinkiewcz, C. A., Mazzone, C. M., D’Agostino, G., Halladay, L. R., Hardaway, J. A., DiBerto, J. F., Navarro, M., Burnham, N., Cristiano, C., Dorrier, C. E., et al. (2016) · Nature · doi:10.1038/nature19318 · Cited by 456 · see citing works
Self-citationSerotonin neurons in the dorsal raphe nucleus encode reward signals
Li, Y., Zhong, W., Wang, D., Feng, Q., Liu, Z., Zhou, J., Jia, C., Hu, F., Zeng, J., Guo, Q., et al. (2016) · Nature Communications · doi:10.1038/ncomms10503 · Cited by 420 · see citing works
Dorsal raphe dopamine neurons represent the experience of social isolation
Matthews, G. A., Nieh, E. H., Vander Weele, C. M., Halbert, S. A., Pradhan, R. V., Yosafat, A. S., Glober, G. F., Izadmehr, E. M., Thomas, R. E., Lacy, G. D., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.040 · Cited by 402 · see citing works
Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.021 · Cited by 379 · see citing works
Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works
Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112345109 · Cited by 333 · see citing works
Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism
Horev, G., Ellegood, J., Lerch, J. P., Son, Y.-E. E., Muthuswamy, L., Vogel, H., Krieger, A. M., Buja, A., Henkelman, R. M., Wigler, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114042108 · Cited by 330 · see citing works
IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Self-citationPortmann, T., Yang, M., Mao, R., Panagiotakos, G., Ellegood, J., Dolen, G., Bader, P. L., Grueter, B. A., Goold, C., Fisher, E., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.036 · Cited by 245 · see citing works
Self-citationSharp, T., Bramwell, S. R., Clark, D. L., & Grahame‐Smith, D. G. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07319.x · Cited by 224 · see citing works
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3591 · Cited by 210 · see citing works
Self-citationActivation of Dorsal Raphe Serotonergic Neurons Promotes Waiting but Is Not Reinforcing
Fonseca, M. S., Murakami, M., & Mainen, Z. F. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.002 · Cited by 210 · see citing works
McDevitt, R. A., Tiran-Cappello, A., Shen, H., Balderas, I., Britt, J. P., Marino, R. A. M., Chung, S. L., Richie, C. T., Harvey, B. K., & Bonci, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.037 · Cited by 203 · see citing works
Raphe GABAergic Neurons Mediate the Acquisition of Avoidance after Social Defeat
Challis, C., Boulden, J., Veerakumar, A., Espallergues, J., Vassoler, F. M., Pierce, R. C., Beck, S. G., & Berton, O. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2383-13.2013 · Cited by 197 · see citing works
MICHELSEN, K., PRICKAERTS, J., & STEINBUSCH, H. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00912-6 · Cited by 196 · see citing works
A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons
Qi, J., Zhang, S. S., Wang, H., Wang, H., Buendia, J. D. J. A., Hoffman, A. F., Lupica, C. R., Seal, R. P., & Morales, M. (2014) · Nature Communications · doi:10.1038/ncomms6390 · Cited by 195 · see citing works
Kane, M. J., Angoa‐Pérez, M., Briggs, D. I., Sykes, C. E., Francescutti, D. M., Rosenberg, D. R., & Kuhn, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048975 · Cited by 140 · see citing works
Correia, P. A., Lottem, E., Banerjee, D., Machado, A. S., Carey, M. R., & Mainen, Z. F. (2017) · eLife · doi:10.7554/elife.20975 · Cited by 138 · see citing works
Steinbusch, H. W. M., van der Kooy, D., Verhofstad, A. A. J., & Pellegrino, A. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90184-6 · Cited by 126 · see citing works
Reward processing by the dorsal raphe nucleus: 5-HT and beyondPreprint
Luo, M., Zhou, J., & Liu, Z. (2015) · Learning & Memory · doi:10.1101/lm.037317.114 · Cited by 117 · see citing works
Optogenetic Modulation of Neural Circuits that Underlie Reward Seeking
Stuber, G. D., Britt, J. P., & Bonci, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.010 · Cited by 110 · see citing works
Nestin-CreER Mice Reveal DNA Synthesis by Nonapoptotic Neurons following Cerebral Ischemia–Hypoxia
Burns, K. A., Ayoub, A. E., Breunig, J. J., Adhami, F., Weng, W.-L., Colbert, M. C., RAKIC, P. T., & Kuan, C.-Y. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl164 · Cited by 87 · see citing works
The role of serotonin in psychiatric disorders
(1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90312-e · Cited by 78 · see citing works
Psychopharmacological Interventions in Autism Spectrum Disorder
Politte, L. C., Henry, C. A., & McDougle, C. J. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000030 · Cited by 73 · see citing works
Appetitive and Aversive Information Coding in the Primate Dorsal Raphé Nucleus
Hayashi, K., Nakao, K., & Nakamura, K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2860-14.2015 · Cited by 71 · see citing works
Establishing causality for dopamine in neural function and behavior with optogenetics
Steinberg, E. E., & Janak, P. H. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.036 · Cited by 52 · see citing works
MDMA as a Probe and Treatment for Social Behaviors
Heifets, B. D., & Malenka, R. C. (2016) · Cell · doi:10.1016/j.cell.2016.06.045 · Cited by 42 · see citing works
Self-citation5-HT1B mRNA expression after chronic social stress
Furay, A. R., McDevitt, R. A., Miczek, K. A., & Neumaier, J. F. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.06.016 · Cited by 30 · see citing works
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Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia
Smith, M. L., Asada, N., & Malenka, R. C. (2021) · Science · doi:10.1126/science.abe3040 · Cited by 368 · see citing works
Self-citationEmbracing diversity in the 5-HT neuronal system
Okaty, B. W., Commons, K. G., & Dymecki, S. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0151-3 · Cited by 319 · see citing works
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice
Guo, B., Chen, J., Chen, Q., Ren, K., Feng, D., Mao, H., Yao, H., Yang, J., Liu, H., Liu, Y., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0445-9 · Cited by 287 · see citing works
Gregorio, D. D., Aguilar‐Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1659-20.2020 · Cited by 261 · see citing works
Self-citationNeuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future
Brzosko, Z., Mierau, S. B., & Paulsen, O. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.041 · Cited by 247 · see citing works
Deep brain optogenetics without intracranial surgery
Chen, R., Gore, F., Nguyen, Q.-A., Ramakrishnan, C., Patel, S., Kim, S. H., Raffiee, M., Kim, Y. S., Hsueh, B., Krook-Magnuson, E. I., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0679-9 · Cited by 229 · see citing works
Self-citationInteracting neural ensembles in orbitofrontal cortex for social and feeding behaviour
Jennings, J. H., Kim, C. K., Marshel, J. H., Raffiee, M., Li, Y., Quirin, S., Pak, S., Ramakrishnan, C., & Deisseroth, K. A. (2019) · Nature · doi:10.1038/s41586-018-0866-8 · Cited by 209 · see citing works
Self-citationNeural circuits of social behaviors: Innate yet flexible
Wei, D., Talwar, V., & Lin, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.012 · Cited by 186 · see citing works
Morel, C., Montgomery, S. E., Li, L., Cuttoli, R. D.-D., Teichman, E. M., Juarez, B., Tzavaras, N., Ku, S. M., Flanigan, M., Cai, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29155-1 · Cited by 159 · see citing works
Self-citationNucleus Accumbens Modulation in Reward and Aversion
Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works
Self-citationBehavioral neuroscience of autism
Takumi, T., Tamada, K., Hatanaka, F., Nakai, N., & Bolton, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.012 · Cited by 163 · see citing works
The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation
Lee, C. R., Chen, A., & Tye, K. M. (2021) · Cell · doi:10.1016/j.cell.2021.02.028 · Cited by 138 · see citing works
Social circuits and their dysfunction in autism spectrum disorder
Sato, M., Nakai, N., Fujima, S., Choe, K. Y., & Takumi, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02201-0 · Cited by 142 · see citing works
Paquelet, G. E., Carrion, K., Lacefield, C., Zhou, P., Hen, R., & Miller, B. R. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.015 · Cited by 129 · see citing works
Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size
Cazettes, F., Reato, D., Morais, J. P., Renart, A., & Mainen, Z. F. (2020) · Current Biology · doi:10.1016/j.cub.2020.09.090 · Cited by 133 · see citing works
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., Walsh, J. J., Sze, J. Y., & Malenka, R. C. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6435 · Cited by 120 · see citing works
Self-citation5-HT modulation of a medial septal circuit tunes social memory stability
Wu, X., Morishita, W., Beier, K. T., Heifets, B. D., & Malenka, R. C. (2021) · Nature · doi:10.1038/s41586-021-03956-8 · Cited by 116 · see citing works
Self-citationNetser, S., Meyer, A., Magalnik, H., Zylbertal, A., Haskal, S., Briller, M., Bizer, A., Grinevich, V., & Wagner, S. (2020) · Nature Communications · doi:10.1038/s41467-020-19569-0 · Cited by 115 · see citing works
Golden, S. A., Jin, M., Heins, C., Vènniro, M., Michaelides, M., & Shaham, Y. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2409-18.2019 · Cited by 111 · see citing works
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
Ouellette, J., Toussay, X., Comin, C. H., Costa, L. D. F., Ho, M. S. H., Lacalle‐Aurioles, M., Andrade, M. F., Liu, Q. Y., Leclerc, S., Pan, Y., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0663-1 · Cited by 104 · see citing works
Canalization and plasticity in psychopathology
Carhart-Harris, R. L., Chandaria, S., Erritzøe, D., Gazzaley, A. H., Girn, M., Kettner, H., Mediano, P. A. M., Nutt, D. J., Rosas, F. E., Roseman, L., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109398 · Cited by 103 · see citing works
Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1
Lituma, P. J., Woo, E., O’Hara, B. F., Castillo, P. E., Sibinga, N. E. S., & Nandi, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115539118 · Cited by 85 · see citing works
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Yu, X.-D., Zhu, Y., Sun, Q.-X., Deng, F., Wan, J., Zheng, D., Gong, W., Xie, S.-Z., Shen, C., Fu, J.-Y., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01200-8 · Cited by 79 · see citing works
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Choe, K. Y., Bethlehem, R. A. I., Safrin, M., Dong, H., Salman, E., Li, Y., Grinevich, V., Golshani, P., DeNardo, L. A., Peñagarikano, O., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.031 · Cited by 77 · see citing works
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Liu, Z., Lin, R., & Luo, M. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-093019-112252 · Cited by 78 · see citing works
Pinto, D. F. C., Yang, H., Dorocic, I. P., de Jong, J. W., Han, V. J., Peck, J. R., Zhu, Y., Liu, C. J., Beier, K. T., Smidt, M. P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12392-2 · Cited by 76 · see citing works
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Pomrenze, M. B., Pinto, D. F. C., Neumann, P. A., Llorach, P., Tucciarone, J., Morishita, W., Eshel, N., Heifets, B. D., & Malenka, R. C. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.024 · Cited by 75 · see citing works
Self-citationCircuit-specific gene therapy reverses core symptoms in a primate Parkinson’s disease model
Chen, Y., Hong, Z., Wang, J., Liu, K., Liu, J., Lin, J., Feng, S., Zhang, T., Shan, L., Liu, T., et al. (2023) · Cell · doi:10.1016/j.cell.2023.10.004 · Cited by 73 · see citing works
The virtuous cycle of human genetics and mouse models in drug discovery
Nadeau, J. H., & Auwerx, J. H. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0009-9 · Cited by 71 · see citing works
Neural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72 · see citing works
Self-citationThe nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 77 · see citing works
Therapeutic mechanisms of psychedelics and entactogens
Heifets, B., & Olson, D. E. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01666-5 · Cited by 64 · see citing works
Self-citationMidbrain circuits of novelty processing
Tapper, A. R., & Molas, S. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107323 · Cited by 71 · see citing works
Transient and sustained effects of dopamine and serotonin signaling in motivation‐related behavior
Yagishita, S. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12942 · Cited by 64 · see citing works
Wenderski, W., Wang, L., Krokhotin, A., Walsh, J. J., Li, H., Shoji, H., Ghosh, S. G., George, R. D., Miller, E. L., Elias, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908238117 · Cited by 60 · see citing works
Self-citationLeo, A., Caro, C. D., Mainardi, P., Tallarico, M., Nesci, V., Marascio, N., Striano, P., Russo, E., Constanti, A., Sarro, G. D., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108782 · Cited by 64 · see citing works
Serotonin transporter availability in adults with autism—a positron emission tomography study
Andersson, M., Tangen, Ä., Farde, L., Bölte, S., Halldin, C., Borg, J., & Lundberg, J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00868-3 · Cited by 64 · see citing works
Oxytocin Receptors Regulate Social Preference in Zebrafish
Landin, J., Hovey, D., Xu, B., Lagman, D., Zettergren, A., Larhammar, D., Kettunen, P., & Westberg, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-61073-4 · Cited by 61 · see citing works
Li, L., Zhang, L., He, Z., Ma, H., Zhang, Y., Xun, Y., Yuan, W., Hou, W., Li, Y.-T., Lv, Z., et al. (2021) · eLife · doi:10.7554/elife.67638 · Cited by 63 · see citing works
Microbiota-gut-brain axis in autism spectrum disorder
Yu, Y., & Zhao, F. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.07.001 · Cited by 63 · see citing works
A discrete serotonergic circuit regulates vulnerability to social stress
Zou, W.-J., Song, Y., Wu, M., Chen, X.-T., You, Q.-L., Yang, Q., Luo, Z.-Y., Huang, L., Kong, Y., Feng, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18010-w · Cited by 57 · see citing works
Tao, C., Zhang, G., Huang, J., Li, Z., Tao, H. W., & Zhang, L. I. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01397-2 · Cited by 60 · see citing works
Robson, M. J., Quinlan, M. A., Margolis, K. G., Gajewski-Kurdziel, P. A., Veenstra-VanderWeele, J. M., Gershon, M. D., Watterson, D. M., & Blakely, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809137115 · Cited by 57 · see citing works
Walsh, J. J., Llorach, P., Cardozo Pinto, D. F., Wenderski, W., Christoffel, D. J., Salgado, J. S., Heifets, B. D., Crabtree, G. R., & Malenka, R. C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01091-6 · Cited by 56 · see citing works
Self-citationSelective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin
Christoffel, D. J., Walsh, J. J., Hoerbelt, P., Heifets, B. D., Llorach, P., Lopez, R. C., Ramakrishnan, C., Deisseroth, K., & Malenka, R. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106648118 · Cited by 54 · see citing works
Self-citationAn Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway
Jamshed, L., Debnath, A., Jamshed, S., Wish, J. V., Raine, J. C., Tomy, G. T., Thomas, P. J., & Holloway, A. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116300 · Cited by 54 · see citing works
Opponent control of reinforcement by striatal dopamine and serotonin
Pinto, D. F. C., Pomrenze, M. B., Guo, M. Y., Touponse, G. C., Chen, A. P. F., Bentzley, B. S., Eshel, N., & Malenka, R. C. (2024) · Nature · doi:10.1038/s41586-024-08412-x · Cited by 54 · see citing works
Self-citationThe Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour
Castroflorio, E., den Hoed, J., Dolmatova, D. M., Finelli, M. J., Cebrian-Serrano, A., Corrochano, S., Bassett, A. R., Davies, B., & Oliver, P. L. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03721-6 · Cited by 50 · see citing works
Galvanic Redox Potentiometry for Fouling‐Free and Stable Serotonin Sensing in a Living Animal Brain
Zhu, F., Xue, Y., Ji, W., Li, X., Ma, W., Yu, P., Jiang, Y. Y., & Mao, L. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202212458 · Cited by 47 · see citing works
Ma, L., Chen, W., Yu, D., & Han, Y. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00015 · Cited by 43 · see citing works
Bayassi-Jakowicka, M., Lietzau, G., Czuba, E., Steliga, A., Waśkow, M., & Kowiański, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189806 · Cited by 43 · see citing works
Tzanoulinou, S., Musardo, S., Contestabile, A., Bariselli, S., Casarotto, G., Magrinelli, E., Jiang, Y., Jabaudon, D., & Bellone, C. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01427-0 · Cited by 43 · see citing works
Hung, L. Y., Alves, N. D., Colle, A. D., Talati, A., Najjar, S. A., Bouchard, V., Gillet, V., Tong, Y., Huang, Z., Browning, K. N., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.11.012 · Cited by 44 · see citing works
Self-citationReviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents
Sun, W., Zhang, G., Huang, J., Tao, C., Seo, M. B., Tao, H. W., & Zhang, L. I. (2025) · Science · doi:10.1126/science.adq2677 · Cited by 40 · see citing works
MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens
Rein, B. A., Raymond, K. B., Boustani, C., Tuy, S., Zhang, J., Laurent, R. S., Pomrenze, M. B., Boroon, P., Heifets, B. D., Smith, M. L., et al. (2024) · Science Advances · doi:10.1126/sciadv.adl6554 · Cited by 37 · see citing works
Self-citationYin, X., Jones, N., Yang, J., Asraoui, N., Mathieu, M., Cai, L., & Chen, S. X. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00815-7 · Cited by 37 · see citing works
Serotonin-releasing agents with reduced off-target effects
Mayer, F. P., Niello, M., Cintulová, D., Sideromenos, S., Maier, J., Li, Y., Bulling, S., Kudlacek, O., Schicker, K. W., Iwamoto, H., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01843-w · Cited by 36 · see citing works
Wang, D., Wang, X., Liu, P., Jing, S.-Q., Du, H., Zhang, L., Jia, F., & Li, A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913922117 · Cited by 36 · see citing works
Deng, W., Ke, H., Wang, S., Li, Z., Li, S., Lv, P., Li, F., & Chen, Y. (2022) · Behavioural Neurology · doi:10.1155/2022/6711160 · Cited by 35 · see citing works
Physical activity promotes brain development through serotonin during early childhood
Jing, J.-Q., Jia, S.-J., & Yang, C.-J. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.015 · Cited by 34 · see citing works
Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations
Kilpatrick, S., Irwin, C. L., & Singh, K. K. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02510-6 · Cited by 34 · see citing works
Toward Optogenetic Hearing Restoration
Huet, A. T., Mager, T., Goßler, C., & Moser, T. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070623-103247 · Cited by 31 · see citing works
Serotonergic modulation of cognitive computations
Doya, K., Miyazaki, K. W., & Miyazaki, K. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.02.003 · Cited by 28 · see citing works
Nygaard, K. R., Maloney, S. E., & Dougherty, J. D. (2019) · Autism Research · doi:10.1002/aur.2154 · Cited by 29 · see citing works
Recent genetic and functional insights in autism spectrum disorder
Nakanishi, M., Anderson, M. P., & Takumi, T. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000718 · Cited by 28 · see citing works
Shiohama, T., Ortuğ, A., Warren, J. L. A., Valli, B., Levman, J. E. D., Faja, S., Tsujimura, K., Maunakea, A. K., & Takahashi, E. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab283 · Cited by 29 · see citing works
Welsch, L., Colantonio, E., Frison, M., Johnson, D. A., McClain, S. P., Mathis, V., Banghart, M. R., Hamida, S. B., Darcq, E., & Kieffer, B. L. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.05.019 · Cited by 34 · see citing works
Friend of the Devil: Negative Social Influences Driving Substance Use Disorders
Pomrenze, M. B., Paliarin, F., & Maiya, R. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.836996 · Cited by 28 · see citing works
Dissecting neural mechanisms of prosocial behaviors
Walsh, J. J., Christoffel, D. J., Wu, X., Pomrenze, M. B., & Malenka, R. C. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.006 · Cited by 29 · see citing works
Self-citationGreene, R. K., Walsh, E. C., Mosner, M. G., & Dichter, G. S. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.12.008 · Cited by 28 · see citing works
Quinlan, M. A., Robson, M. J., Ye, R., Rose, K. L., Schey, K. L., & Blakely, R. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00089 · Cited by 26 · see citing works
Yardımcı, A., Ülker, N., Özgen, A., Ozbeg, G., Ozdede, M. R., Ercan, E. Ç., & Canpolat, S. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137245 · Cited by 30 · see citing works
The effects of tamoxifen on mouse behavior
Li, X., Du, Z., Chen, M., Chen, J., Liang, Z., Ding, X., Zhou, M., Li, S., Li, X., Yang, J., et al. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12620 · Cited by 26 · see citing works
Early and Late Corrections in Mouse Models of Autism Spectrum Disorder
Chung, C., Shin, W., & Kim, E. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.021 · Cited by 23 · see citing works
Interconnected neural circuits mediating social reward
Isaac, J., & Murugan, M. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.10.004 · Cited by 25 · see citing works
Shedding Light on Social Reward Circuitry: (Un)common Blueprints in Humans and Rodents
Grimm, C., Balsters, J. H., & Zerbi, V. (2020) · The Neuroscientist · doi:10.1177/1073858420923552 · Cited by 23 · see citing works
Translational Neuroscience Approaches to Understanding Autism
Veenstra-VanderWeele, J. M., O’Reilly, K. C., Dennis, M. Y., Uribe‐Salazar, J. M., & Amaral, D. G. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230153 · Cited by 24 · see citing works
Martin, H., Choi, J. E., Rodrigues, A. R., & Eshel, N. (2024) · JAACAP Open · doi:10.1016/j.jaacop.2024.01.010 · Cited by 26 · see citing works
Guo, Q., Wang, L., Yuan, W., Li, L., Zhang, J., Hou, W., Yang, Y., Zhang, X., Cai, W., Ma, H., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112553 · Cited by 22 · see citing works
Garrido, D., Beretta, S., Grabrucker, S., Bauer, H. F., Bayer, D., Sala, C., Verpelli, C., Roselli, F., Bockmann, J., Proepper, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01756-8 · Cited by 23 · see citing works
Smith, C. J. W., Rendina, D. N., Kingsbury, M. A., Malacon, K. E., Nguyen, D. M., Tran, J. J., Devlin, B. A., Raju, R. M., Clark, M. J., Burgett, L. A., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02108-w · Cited by 22 · see citing works
Maloney, S. E., Sarafinovska, S., Weichselbaum, C. T., McCullough, K. B., Swift, R. G., Liu, Y., & Dougherty, J. D. (2023) · Cell Reports Methods · doi:10.1016/j.crmeth.2023.100504 · Cited by 20 · see citing works
Jang, S., Park, I., Choi, M., Kim, J., Yeo, S., Huh, S., Choi, J., Moon, C., Choe, H. K., Choe, Y., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01052-7 · Cited by 22 · see citing works
Molecular Plasticity of the Nucleus Accumbens Revisited—Astrocytic Waves Shall Rise
Kardos, J., Dobolyi, Á., Szabó, Z. M., Simon, Á., Lourmet, G. S., Palkovits, M., & Héja, L. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1641-z · Cited by 21 · see citing works
Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence
Zorab, J. M., Li, H., Awasthi, R., Schinasi, A., Cho, Y., O’Loughlin, T. A., & Wu, X. (2025) · Nature · doi:10.1038/s41586-025-08809-2 · Cited by 21 · see citing works
Fontaine, H. M., Silva, P. R., Neiswanger, C., Tran, R., Abraham, A. D., Land, B. B., Neumaier, J. F., & Chavkin, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01178-0 · Cited by 21 · see citing works
Polk, M., & Ikuta, T. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001742 · Cited by 20 · see citing works
The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula
Allain, F., Carter, M., Dumas, S., Darcq, E., & Kieffer, B. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-24395-z · Cited by 20 · see citing works
A ventral hippocampal-lateral septum pathway regulates social novelty preferencePreprint
Rashid, M., Thomas, S., Isaac, J., Karkare, S. C., Klein, H., & Murugan, M. (2024) · eLife · doi:10.7554/elife.97259.2 · Cited by 21 · see citing works
Nishijo, T., Suzuki, E., & Momiyama, T. (2022) · The Journal of Physiology · doi:10.1113/jp282509 · Cited by 19 · see citing works
Kim, H., Kim, D., Cho, Y., Kim, K., Roh, J. D., Kim, Y., Yang, E., Kim, S. S., Ahn, S., Kim, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32748-5 · Cited by 19 · see citing works
Animal models and human tissue compared to better understand and treat the epilepsies
Milior, G., Morin‐Brureau, M., Pallud, J., Miles, R., & Huberfeld, G. (2023) · Epilepsia · doi:10.1111/epi.17552 · Cited by 19 · see citing works
Leone, R., Zuglian, C., Brambilla, R., & Morella, I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1407865 · Cited by 19 · see citing works
Cao, P., Liu, Y., Ni, Z., Zhang, M., Wei, H.-R., Liu, A., Guo, J.-R., Yang, Y., Zheng, X., Guo, Y., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq3874 · Cited by 19 · see citing works
The pleiotropic spectrum of proximal 16p11.2 CNVs
Auwerx, C., Kutalik, Z., & Reymond, A. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.08.015 · Cited by 18 · see citing works
Zhou, M., Niu, B., Ma, J., Ge, Y., Han, Y., Wu, W., & Yue, C. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1535455 · Cited by 22 · see citing works
Establishment of animal models and behavioral studies for autism spectrum disorders
Jiao, D., Xu, Y., Tian, F., Zhou, Y., Chen, D., & Wang, Y. (2024) · Journal of International Medical Research · doi:10.1177/03000605241245293 · Cited by 18 · see citing works
Mitchell, E. J., Thomson, D. M., Openshaw, R. L., Bristow, G. C., Dawson, N., Pratt, J. A., & MORRIS, B. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69130-8 · Cited by 18 · see citing works
Corrigan, F. M., & Christie-Sands, J. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109502 · Cited by 17 · see citing works
Lüscher, C., Emiliani, V., Farahany, N. A., Gittis, A., Gradinaru, V., High, K., Roska, B., Sahel, J.-A., Yizhar, O., Zeng, H.-K., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02097-9 · Cited by 17 · see citing works
Self-citation
- Authors
- Walsh, J. J., Christoffel, D. J., Heifets, B. D., Ben-Dor, G. A., Selimbeyoglu, A., Hung, L. W., Deisseroth, K., & Malenka, R. C.
- Affiliations
- Stanford University (US)
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Malenka, Robert C.
- ORCID
- Venue
- Nature
- Published
- 2018-08
- Volume
- 560
- Issue
- 7720
- Pages
- 589-594
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC8164568
- OpenAlex
- W2887399686
- Cited by
- 256
- References
- 50
- Citations by year
- 2026: 26 · 2025: 40 · 2024: 34 · 2023: 35 · 2022: 29 · 2021: 32 · 2020: 30 · 2019: 25 · 2018: 4
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Simons Foundation
- National Institute of Mental Health (K08MH110610, F32MH103949)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- serotonin release, nucleus accumbens, dorsal raphe neurons, sociability, social dysfunction, autism spectrum disorder, 5-HT1B receptor, optogenetic stimulation, serotonergic neurons, mouse model
- MeSH terms
- Autism Spectrum Disorder, Animals, Chromosome Deletion, Chromosomes, Human, Pair 16, Disease Models, Animal, Humans, Male, Neural Pathways, Nucleus Accumbens, Serotonin, Social Behavior, Synteny, Chromosomes, Mammalian, Mice, Optogenetics, Dorsal Raphe Nucleus
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