The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Whole-mtDNA Genome Sequence Analysis of Ancient African Lineages
Open accessAbstract
Studies of human mitochondrial (mt) DNA genomes demonstrate that the root of the human phylogenetic tree occurs in Africa. Although 2 mtDNA lineages with an African origin (haplogroups M and N) were the progenitors of all non-African haplogroups, macrohaplogroup L (including haplogroups L0-L6) is limited to sub-Saharan Africa. Several L haplogroup lineages occur most frequently in eastern Africa (e.g., L0a, L0f, L5, and L3g), but some are specific to certain ethnic groups, such as haplogroup lineages L0d and L0k that previously have been found nearly exclusively among southern African "click" speakers. Few studies have included multiple mtDNA genome samples belonging to haplogroups that occur in eastern and southern Africa but are rare or absent elsewhere. This lack of sampling in eastern Africa makes it difficult to infer relationships among mtDNA haplogroups or to examine events that occurred early in human history. We sequenced 62 complete mtDNA genomes of ethnically diverse Tanzanians, southern African Khoisan speakers, and Bakola Pygmies and compared them with a global pool of 226 mtDNA genomes. From these, we infer phylogenetic relationships amongst mtDNA haplogroups and estimate the time to most recent common ancestor (TMRCA) for haplogroup lineages. These data suggest that Tanzanians have high genetic diversity and possess ancient mtDNA haplogroups, some of which are either rare (L0d and L5) or absent (L0f) in other regions of Africa. We propose that a large and diverse human population has persisted in eastern Africa and that eastern Africa may have been an ancient source of dispersion of modern humans both within and outside of Africa.
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Citations
Cites
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“In addition, the earliest migrations of modern humans out of Africa are thought to have originated from eastern Africa (Tishkoff et al. 1996; Quintana-Murci et al. 1999; Kivisild et al. 2004).”
BackgroundSelf-citation
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The Genetic Structure and History of Africans and African Americans
Tishkoff, S. A., Reed, F. A., Friedlaender, F. R., Ehret, C., Ranciaro, A., Froment, A., Hirbo, J. B., Awomoyi, A. A., Bodo, J.-M., Doumbo, O., et al. (2009) · Science · doi:10.1126/science.1172257 · Cited by 1,573
Self-citationNew fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens.
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Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
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Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History
Schlebusch, C. M., Skoglund, P., Sjödin, P., Gattepaille, L. M., Hernandez, D., Jay, F., Li, S., De Jongh, M., Singleton, A., Blum, M. G. B., et al. (2012) · Science · doi:10.1126/science.1227721 · Cited by 468
Age of the Association between Helicobacter pylori and Man
Moodley, Y., Linz, B., Bond, R. P., Nieuwoudt, M., Soodyall, H., Schlebusch, C. M., Bernhöft, S., Hale, J., Suerbaum, S., Mugisha, L., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002693 · Cited by 356
Metadata
- Authors
- Gonder, M. K., Mortensen, H. M., Reed, F. A., de Sousa, A., & Tishkoff, S. A.
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12-28
- Volume
- 24
- Issue
- 3
- Pages
- 757-768
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2103468176
- Cited by
- 304
- References
- 9
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gonder, M. K., Mortensen, H. M., Reed, F. A., de Sousa, A., & Tishkoff, S. A. (2007). Whole-mtDNA Genome Sequence Analysis of Ancient African Lineages. Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msl209
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