Yeast Adapts to a Changing Stressful Environment by Evolving Cross-Protection and Anticipatory Gene Regulation
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Organisms can protect themselves against future environmental change. An example is cross-protection, where physiological adaptation against a present environmental stressor can protect an organism against a future stressor. Another is anticipation, where an organism uses information about its present environment to trigger gene expression and other physiological changes adaptive in future environments. "Predictive" abilities like this exist in organisms that have been exposed to periodic changes in environments. It is unknown how readily they can evolve. To answer this question, we carried out laboratory evolution experiments in the yeast Saccharomyces cerevisiae. Specifically, we exposed three replicate populations of yeast to environments that varied cyclically between two stressors, salt stress and oxidative stress, every 10 generations, for a total of 300 generations. We evolved six replicate control populations in only one of these stressors for the same amount of time. We analyzed fitness changes and genome-scale expression changes in all these evolved populations. Our populations evolved asymmetric cross protection, where oxidative stress protects against salt stress but not vice versa. Gene expression data also suggest the evolution of anticipation and basal gene expression changes that occur uniquely in cyclic environments. Our study shows that highly complex physiological states that are adaptive in future environments can evolve on very short evolutionary time scales.
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Growth on glucose was established by genetic and evolutionary engineering in a pyruvate carboxylase-negative S. cerevisiae strain, and a point mutation in the recombinant sfcA gene shifted the co-factor preference from NADH to NADPH.
“Similarly, Zelle and co-workers established growth on glucose by genetic- and evolutionary engineering in a pyruvate carboxylase-negative S. cerevisiae strain. The authors identified a point mutation in the recombinant sfcA gene, which shifted the co-factor preference from NADH to NADPH [107].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [107]
Several studies improved the carbon source utilization of S. cerevisiae strains by genetic engineering in combination with evolutionary adaptation.
“For example, several studies improved the carbon source utilization of S. cerevisiae strains by genetic engineering in combination with evolutionary adaptation [104,107-109].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [107]
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- Authors
- Dhar, R., Sägesser, R., Weikert, C., & Wagner, A.
- Affiliations
- SIB Swiss Institute of Bioinformatics (CH)
- Corresponding author
- Wagner, Andreas
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-11-02
- Volume
- 30
- Issue
- 3
- Pages
- 573-588
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2124042800
- Cited by
- 126
- References
- 92
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 23 · 2023: 12 · 2022: 5 · 2021: 4 · 2020: 19 · 2019: 10 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 6 · 2013: 3
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (315230, 129708)
- Universität Zürich
- SystemsX.ch
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- cross-protection, Saccharomyces cerevisiae, salt stress, oxidative stress, experimental evolution, genome-wide gene expression, fitness change, adaptive evolution
- MeSH terms
- Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Oxidative Stress, Evolution, Molecular, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Saccharomyces cerevisiae Proteins, Microbial Viability, Salt Tolerance, Genetic Fitness, Transcriptome, Gene-Environment Interaction
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