The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization
Abstract
Capacitation is defined as the series of transformations that spermatozoa normally undergo during their migration through the female genital tract, in order to reach and bind to the zona pellucida, undergo the acrosome reaction, and fertilize the egg. During this process, extensive changes occur in all sperm compartments (head and flagellum; membrane, cytosol, cytoskeleton), factors originating from epididymal fluid and seminal plasma are lost or redistributed and membrane lipids and proteins are reorganized; ion fluxes induce biochemical modifications and controlled amounts of reactive oxygen species are generated; spermatozoa develop hyperactivated motility; and complex signal transduction mechanisms are initiated. The main purpose of capacitation is to ensure that spermatozoa reach the eggs at the appropriate time and in the appropriate state to fertilize these eggs, by finely-controlling the rate of the changes necessary to prime spermatozoa and by activating all the mechanisms needed for the subsequent acrosome reaction. The reversibility of some of the mechanisms leading to sperm capacitation may therefore be a very important aspect of the fine regulation and perfect timing of this process.
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Citations
Cites
Human sperm hyperactivation and capacitation as parts of an oxidative process
de Lamirande, E., & Cagnon, C. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90006-g · Cited by 335
Self-citationLow Levels of Nitric Oxide Promote Human Sperm Capacitation In Vitro
Zini, A., de Lamirande, E., & Gagnon, C. (1995) · Journal of Andrology · doi:10.1002/j.1939-4640.1995.tb00558.x · Cited by 183
Self-citationHydrogen Peroxide is Involved in Hamster Sperm Capacitation in Vitro1
Bize, I., Santander, G., Cabello, P., Driscoll, D., & Sharpe, C. (1991) · Biology of Reproduction · doi:10.1095/biolreprod44.3.398 · Cited by 181
Robertson, L., Wolf, D. P., & Tash, J. S. (1988) · Biology of Reproduction · doi:10.1095/biolreprod39.4.797 · Cited by 171
In Vitro Fertilization and Embryo Transfer in the Rhesus Monkey1
Wolf, D. P., Vandevoort, C. A., Meyer-Haas, G. R., Zelinski-Wooten, M. B., Hess, D. L., Baughman, W. L., & Stouffer, R. L. (1989) · Biology of Reproduction · doi:10.1095/biolreprod41.2.335 · Cited by 166
Uhler, M. L., Leungt, A., Chan, S. Y. W., et al. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55568-x · Cited by 158
Physiology: Sperm numbers and distribution within the human Fallopian tube around ovulation
Williams, M., Hill, C. J., Scudamore, I., Dunphy, B., Cooke, I. D., & Barratt, C. L. R. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137975 · Cited by 148
Kinematics of human spermatozoa
David, G., Serres, C., & Jouannet, P. (1981) · Gamete Research · doi:10.1002/mrd.1120040202 · Cited by 117
Zhu, J., Barratt, C. L. R., Lippes, J., Pacey, A. A., & Cooke, I. D. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56768-5 · Cited by 56
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Cited by
Impacts of Oxidative Stress and Antioxidants on Semen Functions
Bansal, A. K., & Bilaspuri, G. S. (2011) · Veterinary Medicine International · doi:10.4061/2011/686137 · Cited by 756
Calcium Channels in the Development, Maturation, and Function of Spermatozoa
Darszon, A., Nishigaki, T., Beltran, C., & Treviño, C. L. (2011) · Physiological Reviews · doi:10.1152/physrev.00028.2010 · Cited by 364
Infections in the male genital tract and reactive oxygen species
Ochsendorf, F. (1999) · Human Reproduction Update · doi:10.1093/humupd/5.5.399 · Cited by 346
Novel signaling pathways involved in sperm acquisition of fertilizing capacity
Visconti, P. E., Westbrook, V. A., Chertihin, O., Demarco, I., Sleight, S., & Diekman, A. B. (2002) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(01)00103-6 · Cited by 342
O'Flaherty, C., de Lamirande, E., & Gagnon, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.027 · Cited by 260
Self-citation
Metadata
- Authors
- de Lamirande, E.
- Venue
- Molecular Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-03-01
- Volume
- 3
- Issue
- 3
- Pages
- 175-194
- ISSN
- 1360-9947 (ISSN-L)
- 1460-2407
- OpenAlex
- W2130801840
- Cited by
- 484
- References
- 13
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- de Lamirande, E. (1997). Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Molecular Human Reproduction. https://doi.org/10.1093/molehr/3.3.175
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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