The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Potential influence of COVID-19/ACE2 on the female reproductive system
Open accessAbstract
The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its physiological functions by modulating the levels of angiotensin II (Ang II) and Ang-(1-7). We reviewed the literature that reported the distribution and function of ACE2 in the female reproductive system, hoping to clarify the potential harm of 2019-nCoV to female fertility. The available evidence suggests that ACE2 is widely expressed in the ovary, uterus, vagina and placenta. Therefore, we believe that apart from droplets and contact transmission, the possibility of mother-to-child and sexual transmission also exists. Ang II, ACE2 and Ang-(1-7) regulate follicle development and ovulation, modulate luteal angiogenesis and degeneration, and also influence the regular changes in endometrial tissue and embryo development. Taking these functions into account, 2019-nCoV may disturb the female reproductive functions through regulating ACE2.
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Cites
1 retracted
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RetractedClinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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Self-citationWang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148
La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Breastfeeding and the use of human milk
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
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Self-citation
Cited by
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 281
The overall impact of COVID ‐19 on healthcare during the pandemic: A multidisciplinary point of view
Sabetkish, N., & Rahmani, A. (2021) · Health Science Reports · doi:10.1002/hsr2.386 · Cited by 68
Metadata
- Authors
- Jing, Y., Run-Qian, L., Hao-Ran, W., Hao-Ran, C., Ya-Bin, L., Yang, G., & Fei, C.
- Venue
- Molecular Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-05-04
- Volume
- 26
- Issue
- 6
- Pages
- 367-373
- ISSN
- 1360-9947 (ISSN-L)
- 1460-2407
- OpenAlex
- W3021809395
- Cited by
- 409
- References
- 104
- FWCI
- 46.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jing, Y., Run-Qian, L., Hao-Ran, W., Hao-Ran, C., Ya-Bin, L., Yang, G., & Fei, C. (2020). Potential influence of COVID-19/ACE2 on the female reproductive system. Molecular Human Reproduction. https://doi.org/10.1093/molehr/gaaa030
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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