5β-Dihydroprogesterone and steroid 5β-reductase decrease in association with human parturition at term

A new mathematical model for relative quantification in real-time RT-PCR

Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works

Prevention of recurrent preterm delivery by 17 alpha–hydroxyprogesterone caproate

Meis, P. J., Klebanoff, M., Thom, E., Dombrowski, M. P., Sibai, B., Moawad, A. H., Spong, C. Y., Hauth, J. C., Miodovnik, M., Varner, M. W., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035140 · Cited by 1,555 · see citing works

Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: A randomized placebo-controlled double-blind study

da Fonseca, E. B., Bittar, R. E., de Carvalho, M. H. B., & Zugaib, M. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.41 · Cited by 785 · see citing works

Inhibition of oxytocin receptor function by direct binding of progesterone

Grazzini, E., Guillon, G., Mouillac, B., & Zingg, H. H. (1998) · Nature · doi:10.1038/33176 · Cited by 466 · see citing works

Progesterone Withdrawal and Estrogen Activation in Human Parturition Are Coordinated by Progesterone Receptor A Expression in the Myometrium

Mesiano, S. A., Chan, E., Fitter, J. T., Kwek, K. Y. C., Yeo, G. S., & Smith, R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8609 · Cited by 427 · see citing works

Interactions between progesterone receptor isoforms in myometrial cells in human labour

Pieber, D. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.9.875 · Cited by 212 · see citing works

Mifepristone for induction of labour

Hapangama, D. K., & Neilson, J. P. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002865.pub2 · Cited by 182 · see citing works

Progestational Agents to Prevent Preterm Birth: A Meta-Analysis of Randomized Controlled Trials

Sanchez‐Ramos, L., Kaunitz, A. M., & Delke, I. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000150559.59531.b2 · Cited by 169 · see citing works

Close kinship of human 20α-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes

Nishizawa, M., Nakajima, T., Yasuda, K., Kanzaki, H., Sasaguri, Y., Watanabe, K., & Ito, S. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00310.x · Cited by 149 · see citing works

Initiation of human parturition

Okita, J. R., MacDonald, P. C., & Johnston, J. M. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)32385-7 · Cited by 142 · see citing works

The ‘See‐Saw’ Theory of Parturition

Csapo, A. I. (1977) · Novartis Foundation symposium · doi:10.1002/9780470720295.ch8 · Cited by 101 · see citing works

The physiological rôles of progesterone, oestradiol-17 and prostaglandin F 2 in the control of ovine parturition.

Liggins, G. C., Sa, G., Kendall, J. Z., & Knox, B. S. (1972) · PubMed · Cited by 79 · see citing works

Mifepristone for induction of labour

Neilson, J. P. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002865 · Cited by 75 · see citing works

Neuroactive Ring A-Reduced Metabolites of Progesterone in Human Plasma during Pregnancy: Elevated Levels of 5α-Dihydroprogesterone in Depressed Patients during the Latter Half of Pregnancy

Murphy, B. E. P., Steinberg, S. I., Hu, F.-Y., & Allison, C. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8122 · Cited by 74 · see citing works

In vitro inhibition of rat uterine contractility induced by 5α and 5β progestins

Kubli‐Garfias, C., Medrano-Conde, L., Beyer, C., & Bondani, A. (1979) · Steroids · doi:10.1016/0039-128x(79)90131-4 · Cited by 64 · see citing works

Recurrent Secretion of Progesterone in Large Amounts: An Endocrine/Metabolic Disorder Unique to Young Women?*

MacDonald, P. C., Dombroski, R. A., & CASEY, M. L. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-4-372 · Cited by 64 · see citing works

Changes in 17β,20α-hydroxysteroid dehydrogenase activity supporting an increase in the estrogen/progesterone ratio of human fetal membranes at parturition

Mitchell, B. F., & Wong, S. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)90768-6 · Cited by 63 · see citing works

Non‐genomic effects of progesterone on the signaling function of G protein‐coupled receptors

Bürger, K., Fahrenholz, F., & Gimpl, G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01668-3 · Cited by 60 · see citing works

Plasma Steroid Concentrations in Maternal and Umbilical Circulation after Spontaneous Onset of Labor*

Mathur, R. S., Landgrebe, S. C., Moody, L. O., POWELL, S., & Williamson, H. O. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-6-1235 · Cited by 55 · see citing works

Genomic organization of a human 5β-reductase and its pseudogene and substrate selectivity of the expressed enzyme

Charbonneau, A., & The, V. L. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00278-5 · Cited by 53 · see citing works

Progesterone, 17-hydroxyprogesterone, estradiol, and estriol in late pregnancy and labor

Mathur, R. S., Landgrebe, S. C., & Williamson, H. O. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90558-x · Cited by 49 · see citing works

Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy?

Mitchell, B. F., Mitchell, J. M., Chowdhury, J., Tougas, M., Engelen, S. M. E., Senff, N., Heijnen, I., Moore, J. T., Goodwin, B., Wong, S., et al. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.01.040 · Cited by 47 · see citing works

Isolation and Characterization of 5α-Pregnane-3, 20-dione and Progesterone in Peripheral Blood of Pregnant Women

Milewich, L., Gómez-Sánchez, C. E., Madden, J. D., & MacDonald, P. C. (2010) · Gynecologic Investigation · doi:10.1159/000301525 · Cited by 47 · see citing works

Inhibition and augmentation of progesterone production during pregnancy: Effects on parturition in rhesus monkeys

Haluska, G. J., Cooka, M. J., & Novy, M. J. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70570-2 · Cited by 44 · see citing works

Tissue Levels of Active and Total Renin, Angiotensinogen, Human Chorionic Gonadotropin, Estradiol, and Progesterone in Human Placentas from Different Methods of Delivery*

Lenz, T., Sealey, J. E., August, P., James, G. D., & Laragh, J. H. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-1-31 · Cited by 42 · see citing works

Progesterone metabolite and spontaneous myometrial contractions in vitro

Thornton, S., Terzidou, V., Clark, A., & Blanks, A. M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05247-7 · Cited by 42 · see citing works

Initiation of human parturition. IX. Progesterone metabolism by placentas of early and late human gestation.

Milewich, L., Gant, N. F., Schwarz, B. E., Chen, G. T., & MacDonald, P. C. (1978) · PubMed · Cited by 39 · see citing works

Initiation of Human Parturition

Milewich, L., Gant, N. F., Schwarz, B. E., CHEN, G. T., & MacDonald, P. C. (1978) · Obstetrics and Gynecology · doi:10.1097/00006250-197803000-00004 · Cited by 39 · see citing works

20α-Hydroxysteroid oxidoreductase activity and 20α-dihydroprogesterone concentration in human placenta before and after parturition

Díaz-Zagoya, J. C., Wiest, W. G., & Arias, F. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90017-6 · Cited by 38 · see citing works

Initiation of human parturition. VIII. Metabolism of progesterone by fetal membranes of early and late human gestation.

Milewich, L., Gant, N. F., Schwarz, B. E., Chen, G. T., & MacDonald, P. C. (1977) · PubMed · Cited by 38 · see citing works

5α-Reductase activity in human placenta

Milewich, L., Gant, N. F., Schwarz, B. E., Chen, G. T., & MacDonald, P. C. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90006-1 · Cited by 36 · see citing works

Progesterone synthesis by human amnion chorion, and decidua at term

Mitchell, B. F., Challis, J. R. G., & Lukash, L. A. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80169-2 · Cited by 35 · see citing works

Progesterone Metabolism in Normal Human Endometrium During the Menstrual Cycle and in Endometrial Carcinoma

Pollow, K., LÜBBERT, H., BOQUOI, E., & Pollow, B. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-4-729 · Cited by 31 · see citing works

Prostaglandin Production during Spontaneous Labor and after Treatment with RU486 in Pregnant Rhesus Macaques1

Haluska, G. J., Kaler, C. A., Cook, M. J., & Novy, M. J. (1994) · Biology of Reproduction · doi:10.1095/biolreprod51.4.760 · Cited by 30 · see citing works

Initiation of Human Parturition. VI. Identification and Quantification of Progesterone Metabolites Produced by the Components of Human Fetal Membranes

Milewich, L., Gant, N. F., Schwarz, B. E., Prough, R. A., Chen, G. T., ATHEY, B., & MacDonald, P. C. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-3-400 · Cited by 29 · see citing works

Steroid hormone changes in fetal blood during labor

Arai, K., & Yanaihara, T. (1977) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(77)90123-5 · Cited by 28 · see citing works

SERUM OESTROGENS AND PROGESTERONE IN MOTHER AND INFANT AT DELIVERY

ANTONIPILLAI, I., & Murphy, B. E. P. (1977) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1977.tb12552.x · Cited by 27 · see citing works

Interrelationships between maternal and cord prolactin, progesterone, estradiol, 13,14-dihydro-15-keto-prostaglandin F2α, and cord cortisol at delivery with respect to initiation of parturition

Haning, R. V., Barrett, D. A., Alberino, S. P., Lynskey, M. T., DONABEDIAN, R. K., & Speroff, L. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90367-8 · Cited by 27 · see citing works

The effects of a progesterone metabolite, 5β‐dihydroprogesterone, on oxytocin receptor binding in human myometrial membranes

Astle, S., Khan, R. N., & Thornton, S. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1046/j.1471-0528.2003.02041.x · Cited by 26 · see citing works

Progesterone metabolism: investigation of the products of metabolism with human liver in vitro

Atherden, L. M. (1959) · Biochemical Journal · doi:10.1042/bj0710411 · Cited by 25 · see citing works

Steroid modulation of pregnenolone to progesterone conversion by human placental cells in vitro

Grimshaw, R. N., Mitchell, B. F., & Challis, J. R. G. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90498-2 · Cited by 25 · see citing works

Plasma estrone, estradiol, estriol, progesterone, and cortisol in normal labor

Okada, D. M., Tulchinsky, D., Ross, J. W., & Hobel, C. J. (1974) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(74)90209-9 · Cited by 24 · see citing works

Simultaneous determination of seven unconjugated steroids in maternal venous and umbilical arterial and venous serum in elective and emergency cesarean section at term

Sippell, W. G., Dörr, H. G., Becker, H., BIDLINGMAIER, F., Mickan, H., & Holzmann, K. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90445-9 · Cited by 23 · see citing works

Isolation and characterization of 5alpha-pregnane-3,20-dione and progesterone in pepipheral blood of pregnant women. measurement throughout pregnancy.

Milewich, L., Gómez-Sánchez, C. E., Jd, M., & Pc, M. (1975) · PubMed · Cited by 20 · see citing works

Genetic Analysis of Fetal Development and Parturition Control in the Mouse

Muglia, L. (2000) · Pediatric Research · doi:10.1203/00006450-200004000-00005 · Cited by 19 · see citing works

Estrogen, progesterone, prolactin, prostaglandin E2, prostaglandin F2α, 13,14-dihydro-15-keto-prostaglandin F2α, and 6-keto-prostaglandin F1α gradients across the uterus in women in labor and not in labor

Davidson, B. J., Murray, R. D., Challis, J. R. G., & Valenzuela, G. J. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80345-9 · Cited by 18 · see citing works

New progesterone metabolites in human myometrium

Junkermann, H., Runnebaum, B., & Lisboa, B. P. (1977) · Steroids · doi:10.1016/0039-128x(77)90131-3 · Cited by 13 · see citing works

Maternal plasma and amniotic fluid cortisol and progesterone concentrations between women with and without term labor. A comparison.

Ohana, E., Mazor, M., Chaim, W., Levy, J., Sharoni, Y., Leiberman, J. R., & Glezerman, M. (1996) · PubMed · Cited by 13 · see citing works

Steroid Sulfohydrolase in Human Chorion and Decidua: Studies Using Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate as Substrate

Chibbar, R., & Mitchell, B. F. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-6-1693 · Cited by 12 · see citing works

Saturated metabolites op progesterone in human myometrium during pregnancy

Mickan, H. (1976) · Steroids · doi:10.1016/0039-128x(76)90069-6 · Cited by 10 · see citing works

High-performance liquid chromatography of progesterone and its metabolites

Walters, D. G., Foster, P. M. D., & Cottrell, R. C. (1981) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)80587-7 · Cited by 10 · see citing works

Peripheral blood concentrations of progesterone and oestradiol during human pregnancy and delivery.

Kauppila, A., & Järvinen, P. A. (1985) · PubMed · Cited by 5 · see citing works

In vitro conversion of pregnenolone to progesterone in human term placenta and fetal membranes before and after onset of labor

Khan‐Dawood, F. S. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80219-3 · Cited by 4 · see citing works

Parturition

Smith, R. (2007) · New England Journal of Medicine · doi:10.1056/nejmra061360 · Cited by 411 · see citing works

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Rižner, T. L., & Penning, T. M. (2014) · Steroids · doi:10.1016/j.steroids.2013.10.012 · Cited by 217 · see citing works

Structural and functional biology of aldo-keto reductase steroid transforming enzymes

Penning, T. M., Wangtrakuldee, P., & Auchus, R. J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00089 · Cited by 164 · see citing works

Progesterone Receptors in the Human Pregnancy Uterus: Do they Hold the Key to Birth Timing?

Mesiano, S. A., Wang, Y., & Norwitz, E. R. (2010) · Reproductive Sciences · doi:10.1177/1933719110382922 · Cited by 161 · see citing works

Steroid hormone control of myometrial contractility and parturition

Mesiano, S. A., & Welsh, T. N. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.05.003 · Cited by 152 · see citing works

The onset of human parturition

Kamel, R. M. A. (2010) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1365-9 · Cited by 120 · see citing works

Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor

Hill, M., Pařı́zek, A., Kancheva, R. L., Dušková, M., Velíková, M., Kříž, L., Klímková, M., Pašková, A., Žižka, Z., Matucha, P., et al. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.10.012 · Cited by 102 · see citing works

Steroid metabolome in fetal and maternal body fluids in human late pregnancy

Hill, M., Pařı́zek, A., Cibula, D., Kancheva, R. L., Jirasek, J. E., Jirkovská, M., Velíková, M., Kubátová, J., Klímková, M., Pašková, A., et al. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.05.007 · Cited by 75 · see citing works

Circulating levels of pregnanolone isomers during the third trimester of human pregnancy

Hill, M., Cibula, D., Havlı́ková, H., Kancheva, L., Fait, T., Kancheva, R. L., Pařı́zek, A., & Stárka, L. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.10.010 · Cited by 69 · see citing works

Neurosteroids in the fetus and neonate: Potential protective role in compromised pregnancies

Hirst, J. J., Palliser, H. K., Yates, D. M., Yawno, T., & Walker, D. W. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.07.018 · Cited by 68 · see citing works

5β-Reduced steroids and human Δ4-3-ketosteroid 5β-reductase (AKR1D1)

Chen, M., & Penning, T. M. (2014) · Steroids · doi:10.1016/j.steroids.2014.01.013 · Cited by 55 · see citing works

Regulation of progesterone signaling during pregnancy: Implications for the use of progestins for the prevention of preterm birth

Byrns, M. C. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.01.015 · Cited by 55 · see citing works

Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)

Chen, M., Drury, J. E., & Penning, T. M. (2011) · Steroids · doi:10.1016/j.steroids.2011.01.003 · Cited by 53 · see citing works

Pathogenesis of Spontaneous Preterm Labor

Romero, R. J., & Lockwood, C. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4224-2.50031-4 · Cited by 50 · see citing works

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo–keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

Jin, Y., Mesaros, A. C., Blair, I. A., & Penning, T. M. (2011) · Biochemical Journal · doi:10.1042/bj20101804 · Cited by 49 · see citing works

Changes in human placental 5a-reductase isoenzyme expression with advancing gestation: effects of fetal sex and glucocorticoid exposure

Vu, T. T. T., Hirst, J. J., Stark, M. J., Wright, I. M. R., Palliser, H. K., Hodyl, N. A., & Clifton, V. L. (2009) · Reproduction Fertility and Development · doi:10.1071/rd08224 · Cited by 46 · see citing works

Relationships of circulating pregnanolone isomers and their polar conjugates to the status of sex, menstrual cycle, and pregnancy

Kancheva, R. L., Hill, M., Cibula, D., Včeláková, H., Kancheva, L., Vrbíková, J., Fait, T., Pařı́zek, A., & Stárka, L. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0192 · Cited by 45 · see citing works

Histone Deacetylase 1 Regulates the Expression of Progesterone Receptor A During Human Parturition by Occupying the Progesterone Receptor A Promoter

Ke, W., Chen, C., Luo, H., Tang, J., Zhang, Y., Gao, W., Yang, X., Tian, Z., Chang, Q., & Liang, Z. (2016) · Reproductive Sciences · doi:10.1177/1933719115625848 · Cited by 38 · see citing works

Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-A promoter

Chai, S., Smith, R., Zakár, T., Mitchell, C., & Madsen, G. (2012) · Molecular Human Reproduction · doi:10.1093/molehr/gas012 · Cited by 36 · see citing works

Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes

Lee, Y. J., Sooranna, S. R., Terzidou, V., Christian, M., Brosens, J. J., Huhtinen, K., POUTANEN, M. H., Barton, G. R., Johnson, M. R., & Bennett, P. R. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01567.x · Cited by 35 · see citing works

Reduced Progesterone Metabolites in Human Late Pregnancy

Hill, M., Pařı́zek, A., Kancheva, R. L., & Jirasek, J. E. (2011) · Physiological Research · doi:10.33549/physiolres.932077 · Cited by 32 · see citing works

The Comparative Physiology of Parturition in Mammals: Hormones and Parturition in Mammals

Young, I. R., Renfree, M. B., Mesiano, S. A., Shaw, G., Jenkin, G., & Smith, R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374928-4.10006-9 · Cited by 33 · see citing works

The Crystal Structure of Human Δ4-3-Ketosteroid 5β-Reductase Defines the Functional Role of the Residues of the Catalytic Tetrad in the Steroid Double Bond Reduction Mechanism

Faucher, F., Cantin, L., Luu-The, V., Labrie, F., & Breton, R. (2008) · Biochemistry · doi:10.1021/bi800572s · Cited by 30 · see citing works

Stress in Pregnancy: A Role for Neuroactive Steroids in Protecting the Fetal and Neonatal Brain

Hirst, J. J., Walker, D. W., Yawno, T., & Palliser, H. K. (2009) · Developmental Neuroscience · doi:10.1159/000232555 · Cited by 30 · see citing works

Conversion of Human Steroid 5β-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H

Chen, M., Drury, J. E., Christianson, D. W., & Penning, T. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338780 · Cited by 26 · see citing works

Crystal Structures of Human Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition,

Faucher, F., Cantin, L., Luu-The, V., Labrie, F., & Breton, R. (2008) · Biochemistry · doi:10.1021/bi801276h · Cited by 27 · see citing works

Is Maternal Progesterone Actually Independent of the Fetal Steroids?

Hill, M., Pařı́zek, A., Jirásek, J. E., Jirkovská, M., Velíková, M., Dušková, M., Klímková, M., Pašková, A., Žižka, Z., Germanová, A., et al. (2010) · Physiological Research · doi:10.33549/physiolres.931807 · Cited by 27 · see citing works

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Jin, Y., Chen, M., & Penning, T. M. (2014) · Biochemical Journal · doi:10.1042/bj20140220 · Cited by 25 · see citing works

The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies

Nikolaou, N., Hodson, L., & Tomlinson, J. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105808 · Cited by 24 · see citing works

Role of Aldo–Keto Reductase Enzymes in Mediating the Timing of Parturition

Byrns, M. C. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00092 · Cited by 24 · see citing works

Progesterone levels in cesarean and normal delivered term placentas

Feinshtein, V., Ben‐Zvi, Z., Sheiner, E., Amash, A., Sheizaf, B., & Holcberg, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1125-x · Cited by 21 · see citing works

Progesterone metabolites, “xenobiotic-sensing” nuclear receptors, and the metabolism of maternal steroids

Paitz, R. T., & Bowden, R. M. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.11.011 · Cited by 20 · see citing works

Decreased DNA Methylations at the Progesterone Receptor Promoter A Induce Functional Progesterone Withdrawal in Human Parturition

Li, X., Chen, C., Luo, H., van Velkinburgh, J. C., Ni, B., & Chang, Q. (2014) · Reproductive Sciences · doi:10.1177/1933719113518982 · Cited by 17 · see citing works

A possible role for progesterone metabolites in human parturition

Sheehan, P. M. (2006) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2006.00548.x · Cited by 17 · see citing works

5β-Dihydrosteroids: Formation and Properties

Penning, T. M., & Covey, D. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168857 · Cited by 15 · see citing works

In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency

Chen, M., Jin, Y., & Penning, T. M. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00816 · Cited by 12 · see citing works

Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid

Chen, M., Wangtrakuldee, P., Zang, T., Duan, L., Gathercole, L., Tomlinson, J., & Penning, T. M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.03.025 · Cited by 10 · see citing works

Treatment with an inhibitor of catechol- O -methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats

Wentz, M. J., Shi, S.-Q., Shi, L., Salama, S. A., Harirah, H. M., Fouad, H. M., Garfield, R. E., & Al-Hendy, A. A. (2007) · Reproduction · doi:10.1530/rep-07-0245 · Cited by 9 · see citing works

The Comparative Physiology of Parturition in Mammals: Hormones and Parturition in Mammals

Young, I. R., Renfree, M. B., Mesiano, S. A., Shaw, G., Jenkin, G., & Smith, R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374932-1.00053-6 · Cited by 5 · see citing works

PROGESTERONE AND THE CONTROL OF HUMAN PREGNANCY AND PARTURITION

Mesiano, S. A., & Welsh, T. N. (2009) · Fetal and Maternal Medicine Review · doi:10.1017/s096553950900240x · Cited by 3 · see citing works

Analysis of Progestagens

Wood, P. J., & Gower, D. B. (2010) · Springer eBooks · doi:10.1023/b135931_7 · Cited by 4 · see citing works

Progesterone metabolism in bovine endometrial cells and the effect of metabolites on the responsiveness of the cells to OT-stimulation of PGF2α

JAMSHIDI, A., GIRARD, D., Beaudry, F., & GOFF, A. K. (2007) · Steroids · doi:10.1016/j.steroids.2007.07.005 · Cited by 3 · see citing works

Mammalian Labor: Variations on a Theme by Amniota

Smith, R., Zakár, T., & Madsen, G. (2013) · Endocrinology · doi:10.1210/en.2012-2262 · Cited by 2 · see citing works

LC-MS/MS quantitation of the primary reduced metabolites of progesterone in serum during the third trimester of human pregnancy reveals a potential role for 20β-hydroxyprogesterone and 5β-dihydroprogesterone in functional progesterone withdrawal

Hinchliffe, E., & Heazell, A. E. P. (2025) · Steroids · doi:10.1016/j.steroids.2025.109724 · Cited by 1 · see citing works

Placental Production of Peptide, Steroid, and Lipid Hormones

Strauss, J. F., & Mesiano, S. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814823-5.00041-6 · Cited by 1 · see citing works

Cloning, expression, and purification of recombinant AKR1D1 for therapeutic applications

Shutevska, K., & Nestorovska, A. K. (2024) · Acta Pharmaceutica · doi:10.2478/acph-2025-0003 · Cited by 1 · see citing works

Physiological Relevance of Pregnanolone Isomers and Their Polar Conjugates with Respect to the Gender, Menstrual Cycle and Pregnancy

Hill, M., Pařı́zek, A., Kancheva, R. L., Cibula, D., Madzarov, N., & Stark, L. (2011) · InTech eBooks · doi:10.5772/16656

The Endocrine Regulation of Human Labor

Smith, R., Smith, J. I., & Bisits, A. M. (2010) · Wiley eBooks · doi:10.1002/9781444317619.ch8 · Cited by 1 · see citing works

Parturition

Bala, R. (2022) · Springer eBooks · doi:10.1007/978-3-319-55065-7_513 · Cited by 1 · see citing works

5β-Dihydroprogesterone and Human Preterm Labor

Sheehan, P. M., Rice, G. E., & Brennecke, S. P. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.45013

Parturition

Bala, R. (2019) · Springer eBooks · doi:10.1007/978-3-319-47829-6_513-1

Hormones and the comparative physiology of parturition in mammals

Young, I. R., Renfree, M. B., Mesiano, S. A., Shaw, G., Jenkin, G., & Smith, R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-443-15986-2.00004-6

in association with human parturition at term

Sheehan, P. M., Rice, G. E., Moses, E. K., & Brennecke, S. P. (2015)

5β-Dihydroprogesterone and Human Preterm Labor

Sheehan, P. M., Rice, G. E., & Brennecke, S. P. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.45013

Progesterone in human parturition : progesterone and 5α-pregnane-3,20-dione in relation to human myometrial activity

Löfgren, M. (1991)

20α-Hydroxysteroid oxidoreductase activity and 20α-dihydroprogesterone concentration in human placenta before and after parturition

Díaz-Zagoya, J. C., Wiest, W. G., & Arias, F. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90017-6 · Cited by 38 · see citing works

Decrease in Serum Concentration of 5α‐Pregnane‐3,20‐Dione Prior to Spontaneous Labor

Löfgren, M., Bäckström, T. C., & Joelsson, I. (1988) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348809004262 · Cited by 16 · see citing works