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The Effect of Allelic Variation in Aldo-Keto Reductase 1C2 on the in Vitro Metabolism of Dihydrotestosterone

Takahashi, R. H., Grigliatti, T. A., Reid, R. E., & Riggs, K. W. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.150995 · Cited by 21 · see citing works

P0188 SRD5B1 (AKR1D1) GENE ANALYSIS IN DELTA4???3-OXOSTEROID 5BETA-REDUCTASE DEFICIENCY: EVIDENCE FOR PRIMARY GENETIC DEFECT

Gonzales, E. M., Cresteil, D., Baussan, C., Dabadie, A., Gerhardt, M., & Jacquemin, E. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200406001-00312 · Cited by 20 · see citing works

Alanine Scanning Mutagenesis of the Testosterone Binding Site of Rat 3α-Hydroxysteroid Dehydrogenase Demonstrates Contact Residues Influence the Rate-Determining Step

Heredia, V. V., Cooper, W. C., Kruger, R. G., Jin, Y., & Penning, T. M. (2004) · Biochemistry · doi:10.1021/bi0499563 · Cited by 19 · see citing works

Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity

Zhang, B., Zhu, D., Hu, X., Zhou, M., Shang, P., & Lin, S. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.01.003 · Cited by 16 · see citing works

The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function

Mindnich, R., Drury, J. E., & Penning, T. M. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.12.020 · Cited by 16 · see citing works

Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis

El-Kabbani, O. A. L., Dhagat, U., Soda, M., Endo, S., Matsunaga, T., & Hara, A. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.01.076 · Cited by 12 · see citing works

In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency

Chen, M., Jin, Y., & Penning, T. M. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00816 · Cited by 12 · see citing works

Kinetic alteration of a human dihydrodiol/3α-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine

Tatuya, O. H. T. A., Ishikura, S., Shintani, S., Usami, N., & Hara, A. (2000) · Biochemical Journal · doi:10.1042/bj3520685 · Cited by 9 · see citing works

Functional Significance May Underlie the Taxonomic Utility of Single Amino Acid Substitutions in Conserved Proteins

Tyler, K. M., Wagner, G. K., Wu, Q., & Huber, K. T. (2010) · Journal of Molecular Evolution · doi:10.1007/s00239-010-9338-y · Cited by 8 · see citing works

A Single Nucleotide Variant in the Promoter Region of 17β-HSD Type 5 Gene Influences External Genitalia Virilization in Females with 21-Hydroxylase Deficiency

Kaupert, L. C., Gomes, L. G., Brito, V. N., de Lemos‐Marini, S. H. V., de Mello, M. P., Longui, C. A., Kochi, C., de Castro, M., Guerra‐Júnior, G., Mendonca, B. B., et al. (2016) · Hormone Research in Paediatrics · doi:10.1159/000445684 · Cited by 7 · see citing works

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works

11-Oxygenated androgens in health and disease

Turcu, A. F., Rege, J., Auchus, R. J., & Rainey, W. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0336-x · Cited by 217 · see citing works

The Biosynthesis of Enzymatically Oxidized Lipids

Hajeyah, A. A., Griffiths, W. J., Wang, Y., Finch, A. J., & O’Donnell, V. B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.591819 · Cited by 192 · see citing works

Aldo-Keto Reductases and Cancer Drug Resistance

Penning, T. M., Jonnalagadda, S. K., Trippier, P. C., & Rižner, T. L. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000122 · Cited by 152 · see citing works

Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega

Doden, H. L., & Ridlon, J. M. (2021) · Microorganisms · doi:10.3390/microorganisms9030469 · Cited by 110 · see citing works

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

Zuo, X., Zeng, H., Wang, B., Yang, X., He, D., Wang, L., Ouyang, H. W., & Yuan, J. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.10.3 · Cited by 109 · see citing works

Conversion of Classical and 11-Oxygenated Androgens by Insulin-Induced AKR1C3 in a Model of Human PCOS Adipocytes

Paulukinas, R. D., Mesaros, C., & Penning, T. M. (2022) · Endocrinology · doi:10.1210/endocr/bqac068 · Cited by 63 · see citing works

Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer

Endo, S., Oguri, H., Segawa, J., Kawai, M., Hu, D., Xia, S., Okada, T., Irie, K., Fujii, S., Gouda, H., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00939 · Cited by 63 · see citing works

Gut feelings about bacterial steroid-17,20-desmolase

Ly, L. K., Doden, H. L., & Ridlon, J. M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111174 · Cited by 43 · see citing works

Pleiotropic Actions of Aldehyde Reductase (AKR1A)

Fujii, J., Homma, T., Miyata, S., & Takahashi, M. (2021) · Metabolites · doi:10.3390/metabo11060343 · Cited by 42 · see citing works

Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer

Sahu, R., Mishra, R., Kumar, R., Salahuddin, S., Majee, C., Mazumder, A., & Kumar, A. (2021) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557521666210614162031 · Cited by 39 · see citing works

AKR1C3 regulated by NRF2/MAFG complex promotes proliferation via stabilizing PARP1 in hepatocellular carcinoma

Pan, D., Yang, W., Zeng, Y., Qin, H., Xu, Y., Gui, Y., Fan, X., Tian, G., Wu, Y., Sun, H., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02379-7 · Cited by 37 · see citing works

Self-cascade deoxynivalenol detoxification by an artificial enzyme with bifunctions of dehydrogenase and aldo/keto reductase from genome mining

Niu, J., Yan, R., Zhou, H., Ma, B., Lu, Z., Meng, F., Lü, F., & Ping, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129512 · Cited by 32 · see citing works

Hormone-linked redox status and its modulation by antioxidants

Sahoo, D. K., & Chainy, G. B. N. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2022.10.007 · Cited by 33 · see citing works

Cytochrome P450 and Other Drug-Metabolizing Enzymes As Therapeutic Targets

Foti, R. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.001011 · Cited by 30 · see citing works

Integration of androgen hormones in endometrial cancer biology

Gjorgoska, M., & Rižner, T. L. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.06.001 · Cited by 27 · see citing works

Targeting sex steroid biosynthesis for breast and prostate cancer therapy

POUTANEN, M. H., Thulin, M. H., & Härkönen, P. L. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00609-y · Cited by 28 · see citing works

Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis

Martin, C., Crastin, A., Sagmeister, M. S., Kalirai, M. S., Turner, J. D., MacDonald, L., Kurowska‐Stolarska, M., Scheel‐Toellner, D., TAYLOR, A. E. R., Gilligan, L. C., et al. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103263 · Cited by 26 · see citing works

AKR1C3 Is Associated with Better Survival of Patients with Endometrial Carcinomas

Hojnik, M., Šuster, N. K., Smrkolj, Š., Grazio, S. F., Verdenik, I., & Rižner, T. L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124105 · Cited by 26 · see citing works

Aldo-keto reductases: Role in cancer development and theranostics

Nagini, S., Kallamadi, P. R., Tanagala, K. K. K., & Reddy, G. B. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.049918 · Cited by 25 · see citing works

The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies

Nikolaou, N., Hodson, L., & Tomlinson, J. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105808 · Cited by 24 · see citing works

Aldo-keto reductase (AKR) superfamily website and database: An update

Huacachino, A. A., Joo, J., Narayanan, N., Tehim, A., Himes, B. E., & Penning, T. M. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111111 · Cited by 25 · see citing works

Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens

Schiffer, L., Bossey, A., Kempegowda, P., TAYLOR, A. E. R., Akerman, İ., Scheel‐Toellner, D., Storbeck, K., & Arlt, W. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1077 · Cited by 22 · see citing works

Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases

Detlefsen, A. J., Paulukinas, R. D., & Penning, T. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031873 · Cited by 23 · see citing works

Bioinformatics analysis of ferroptosis-related gene AKR1C3 as a potential biomarker of asthma and its identification in BEAS-2B cells

Wang, Y., Fan, J., Yu, T., Wang, L., Wang, L., Weng, C., Lai, C., Song, J., & Zhang, W. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106740 · Cited by 21 · see citing works

Progesterone and its receptor signaling in cervical remodeling: Mechanisms of physiological actions and therapeutic implications

Tripathy, S., Nallasamy, S., & Mahendroo, M. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106137 · Cited by 19 · see citing works

Electrochemical Biosensing of Glucose Based on the Enzymatic Reduction of Glucose

Soranzo, T., Tahar, A. B., Chmayssem, A., Zelsmann, M., Vadgama, P. M., Lenormand, J., Cinquin, P., Martin, D. K., & Zebda, A. (2022) · Sensors · doi:10.3390/s22197105 · Cited by 19 · see citing works

Insulin-Induced AKR1C3 Induces Fatty Acid Synthase in a Model of Human PCOS Adipocytes

Paulukinas, R. D., & Penning, T. M. (2023) · Endocrinology · doi:10.1210/endocr/bqad033 · Cited by 19 · see citing works

Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis

Sun, C., Liu, W., Lu, Z., Li, Y., Liu, S., Tang, Z., Yan, Y., Li, Z., Feng, H., Zhang, D., et al. (2021) · Theranostics · doi:10.7150/thno.53624 · Cited by 19 · see citing works

AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin

Badmann, S., Mayr, D. C., Schmoeckel, E., Hester, A., Buschmann, C., Beyer, S., Kolben, T., Kraus, F. B. T., Chelariu-Raicu, A., Burges, A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-05785-9 · Cited by 18 · see citing works

Regulation Network and Prognostic Significance of Aldo-Keto Reductase (AKR) Superfamily Genes in Hepatocellular Carcinoma

Dai, T., Ye, L., Yu, H., Li, K., Li, J., Liu, R., Lü, X. C., Deng, M., Li, R., Liu, W., et al. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s323743 · Cited by 17 · see citing works

X-ray structure of human aldo–keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis

Marinović, M. A., Bekić, S. S., Kugler, M., Brynda, J., Škerlová, J., Škorić, D., Řezáčová, P., Petri, E. T., & Ćelić, A. S. (2022) · RSC Medicinal Chemistry · doi:10.1039/d2md00387b · Cited by 17 · see citing works

Pyridine Moiety: Recent Advances in Cancer Treatment

Sahu, R., Mishra, R., Kumar, R., Majee, C., Salahuddin, S., MAZUMDER, A., & Kumar, A. (2021) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.763 · Cited by 16 · see citing works

Progesterone Metabolism by Human and Rat Hepatic and Intestinal Tissue

Coombes, Z., Plant, K., Freire, C., Basit, A. W., Butler, P. J., Conlan, R. S., & González, D. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101707 · Cited by 16 · see citing works

5β-Dihydrosteroids: Formation and Properties

Penning, T. M., & Covey, D. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168857 · Cited by 15 · see citing works

Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators

Endo, S., Morikawa, Y., Matsunaga, T., Hara, A., & Nishinaka, T. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106113 · Cited by 16 · see citing works

Effects of Pregnanolone Glutamate and Its Metabolites on GABA A and NMDA Receptors and Zebrafish Behavior

Abramova, V., Alvarado, V. L., Hill, M., Smejkalová, T., Malý, M., Valeš, K., Dittert, I., Božíková, P., Kysilov, B., Krausová, B. H., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00131 · Cited by 14 · see citing works

Advances in aldo-keto reductases immobilization for biocatalytic synthesis of chiral alcohols

Zhang, W., Shao, Z.-Q., Wang, Z., Ye, Y., Li, S., & Wang, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133264 · Cited by 14 · see citing works

Transcript Levels of Aldo-Keto Reductase Family 1 Subfamily C (AKR1C) Are Increased in Prostate Tissue of Patients with Type 2 Diabetes

Frankó, A., Berti, L., Hennenlotter, J., Rausch, S., Scharpf, M. O., de Angelis, M. H., Stenzl, A., Birkenfeld, A. L., Peter, A., Lutz, S. Z., et al. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030124 · Cited by 14 · see citing works

The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains

Kudová, E., Mareš, P., Hill, M., Vondráková, K., Tsenov, G., Chodounská, H., Kubová, H., & Valeš, K. (2021) · Pharmaceuticals · doi:10.3390/ph15010049 · Cited by 14 · see citing works

Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3

Möller, G., Temml, V., Cala, A., Gruet, O., Richomme, P., Séraphin, D., Viault, G., Kraus, L., Huber‐Cantonati, P., Schopfhauser, E., et al. (2022) · Metabolites · doi:10.3390/metabo12020099 · Cited by 15 · see citing works

Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model

Krishnaiah, M., Jonnalagadda, S. K., Morsy, A., Duan, L., Chhonker, Y. S., Murry, D. J., Penning, T. M., & Trippier, P. C. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00732 · Cited by 13 · see citing works

4-Deoxy-l-erythro-5-hexoseulose Uronate (DEH) and DEH Reductase: Key Molecule and Enzyme for the Metabolism and Utilization of Alginate

Kawai, S., & Hashimoto, W. (2022) · Molecules · doi:10.3390/molecules27020338 · Cited by 13 · see citing works

Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition

Basit, A., Amory, J. K., Mettu, V. S., Li, C. Y., Heyward, S. A., Jariwala, P. B., Redinbo, M. R., & Prasad, B. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.000975 · Cited by 13 · see citing works

Novel D-modified heterocyclic androstane derivatives as potential anticancer agents: Synthesis, characterization, in vitro and in silico studies

Šestić, T. L., Ajduković, J. J., Bekić, S. S., Ćelić, A. S., Stojanović, S., Najman, S. J., Marinović, M. A., Petri, E. T., Škorić, D., & Savić, M. P. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106362 · Cited by 12 · see citing works

Function, drug resistance and prognostic effect of AKR1C2 in human cancer

Wang, Z., Feng, Y., Song, J., Sun, D., & Zhang, Y. (2023) · Neoplasma · doi:10.4149/neo_2023_230206n66 · Cited by 12 · see citing works

The Role of Prostaglandins as Major Inflammatory Mediators in Colorectal Cancer

Macia-Guardado, M., Lutz, V., Hengstschläger, M., & Dolznig, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412191 · Cited by 15 · see citing works

Genome-wide analysis revealed the stepwise origin and functional diversification of HSDs from lower to higher plant species

Saleem, N., Aziz, U., Ali, M., Liu, X., Alwutayd, K. M., Alshegaihi, R. M., Niedbała, G., Elkelish, A., & Zhang, M. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1159394 · Cited by 11 · see citing works

Differential activity and expression of human 5β-reductase (AKR1D1) splice variants

Appanna, N., Gibson, H., Gangitano, E., Dempster, N. J., Morris, K., George, S., Arvaniti, A., Gathercole, L., Keevil, B. G., Penning, T. M., et al. (2021) · Journal of Molecular Endocrinology · doi:10.1530/jme-20-0160 · Cited by 11 · see citing works

Functional Protein Composition in Femoral Glands of Sand Lizards (Lacerta agilis)

Ibáñez, A., Skupień-Rabian, B., Jankowska, U., Kędracka–Krok, S., Zając, B., & Pabijan, M. (2022) · Molecules · doi:10.3390/molecules27072371 · Cited by 11 · see citing works

Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

Detlefsen, A. J., Wangtrakuldee, P., & Penning, T. M. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106121 · Cited by 12 · see citing works

Investigation of the Potential of Bile Acid Methyl Esters as Inhibitors of Aldo‐keto Reductase 1C2: Insight from Molecular Docking, Virtual Screening, Experimental Assays and Molecular Dynamics

Marinović, M., Petri, E. T., Grbović, L. M., Vasiljević, B., Jovanović-Šanta, S., Bekić, S. S., & Ćelić, A. S. (2022) · Molecular Informatics · doi:10.1002/minf.202100256 · Cited by 11 · see citing works

Synthesis and biological evaluation of novel D-ring fused steroidal N (2)-substituted-1,2,3-triazoles

Tenjović, B., Bekić, S. S., Ćelić, A. S., Petri, E. T., Scholda, J., Kopp, F. B., Sakač, M. N., & Nikolić, A. R. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00297k · Cited by 10 · see citing works

Relationship between cholestasis and altered progesterone metabolism in the placenta-maternal liver tandem

Sanchon-Sanchez, P., Herráez, E., Macı́as, R. I. R., Estiú, M. C., Fortes, P., Monte, M. J., Marı́n, J. J. G., & Romero, M. R. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166926 · Cited by 10 · see citing works

Synthesis and Medicinal Applications of Fenamic Acid Derivatives

Sharma, M., & Prasher, P. (2023) · Current Organic Chemistry · doi:10.2174/1385272827666230914113509 · Cited by 9 · see citing works

AKR1B10 and digestive tumors development: a review

Shen, Y., Qiu, A., Huang, X., Wen, X., Shehzadi, S., He, Y., Hu, Q., Zhang, J., Luo, D., & Yang, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1462174 · Cited by 9 · see citing works

AKR1B10 as a novel prognostic biomarker linking methylation and immune escape in hepatocellular carcinoma

Khan, M. N., Binli, M., Hu, J., Mengjia, S., Shunyao, W., & Li, X. (2025) · Discover Oncology · doi:10.1007/s12672-025-03017-w · Cited by 9 · see citing works

SRSF3-Mediated Ki67 Exon 7-Inclusion Promotes Head and Neck Squamous Cell Carcinoma Progression via Repressing AKR1C2

Liu, M., Lin, C., Huang, Q.-W., Jia, J., Guo, J., & Jia, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043872 · Cited by 9 · see citing works

Role of Human Aldo–Keto Reductases in the Nitroreduction of 1-Nitropyrene and 1,8-Dinitropyrene

Su, A. L., Mesaros, C., Krzeminski, J., El‐Bayoumy, K., & Penning, T. M. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00271 · Cited by 10 · see citing works

5-Hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells

Hardaway, A., Goudarzi, M., Berk, M. P., Chung, Y., Zhang, R., Li, J., Klein, E. A., & Sharifi, N. (2022) · Endocrinology · doi:10.1210/endocr/bqac191 · Cited by 9 · see citing works

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels

Shi, T., Fan, Q., Liu, S., & Zhang, S. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116309 · Cited by 8 · see citing works

Adaptive loss of shortwave-sensitive opsins during cartilaginous fish evolution

Zhang, B., Feng, Y., Lv, M., Jia, L., Liao, Y., Xu, X., Meyer, A., Sun, J., Fan, G., Li, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62544-w · Cited by 8 · see citing works

A dirigent protein redirects extracellular terpenoid metabolism for defense against biotic challenges

Lin, J., Wu, W., Nie, G., Li, J., Fang, X., Sheng, Y.-G., Wang, M., Zheng, Q.-Y., Guo, X., Huang, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64323-z · Cited by 8 · see citing works

Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases

Ding, L., Jin, L., & Huang, W. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100115 · Cited by 9 · see citing works

Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid

Manzella, F. M., Cabrera, O. H., Wilkey, D., Fine-Raquet, B., Klawitter, J., Krishnan, K., Covey, D. F., Jevtović‐Todorović, V., & Todorovic, S. M. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.09.025 · Cited by 8 · see citing works

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue

Oakley, J., Hill, M., Giess, A. P., Tanguy, M., & Elgar, G. S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04711-5 · Cited by 9 · see citing works

Specific and potent inhibition of steroid hormone pre-receptor regulator AKR1C2 by perfluorooctanoic acid: Implications for androgen metabolism

Huacachino, A. A., Chung, A., Sharp, K. A., & Penning, T. M. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106641 · Cited by 8 · see citing works

Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine

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Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study

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Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation

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Combined MD and QM/MM Investigations of Hydride Reduction of 5α-Dihydrotestosterone Catalyzed by Human 3α-Hydroxysteroid Dehydrogenase Type 3: Importance of Noncovalent Interactions

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Switching the chemoselectivity of perakine reductase for selective reduction of α,β-unsaturated ketones by Arg127 mutation

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An integrated RNA‐Seq and network study reveals the effect of nicotinamide on adrenal androgen synthesis

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Phylogenetic and transcriptomic study of aldo-keto reductases in Haemonchus contortus and their inducibility by flubendazole

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Evolutionary dynamics and functional characterization of proximal duplicated sorbitol-6-phosphate dehydrogenase genes in Rosaceae

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Sudan II and IV induce liver carcinogenesis through interactions with AKR1D1 in computational and experimental studies insights from the Taiwan Sudan Red chili pepper incident

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Unlocking the industrial potential of ketoreductase: insights from two decades of discovery, evolution, and global impact.

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Assessment of steroid enzymes action in children and adolescents with obesity

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Cancer to Cataracts: The Mechanistic Impact of Aldo-Keto Reductases in Chronic Diseases

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Reshaping the active pocket of an aldo-keto reductase to enhance its detoxification activity towards 3-keto-deoxynivalenol

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Adipocyte maturation impacts daunorubicin disposition and metabolism

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Discovery of highly potent AKR1Cs pan-inhibitors as chemotherapeutic potentiators to restore breast cancer drug resistance

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Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver

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Unlocking Loop Geometric Remodeling Redirects Aldo-Keto Reductase from Substrate Promiscuity to 3-Keto-Deoxynivalenol Specificity

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Exploring the roles of AKR1C1, AKR1C2, and AKR1C3 in the nervous system: Mechanisms and perspectives

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AKR1B1 bridges metabolic pathways and disease progression

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Enzyme Engineering and Cofactor Recycling Enable Efficient Biosynthesis of Neuroactive 3α-OH-5β-H Steroids with C3 Glycosylation

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Involvement of porcine and human carbonyl reductases in the metabolism of epiandrosterone, 11-oxygenated steroids, neurosteroids, and corticosteroids

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Cloning and characterization of steroid 5β-reductase from the venom gland of Bufo bufo gargarizans

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Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome

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Promiscuity and diversity in 3-ketosteroid reductases

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