Cited by 192Prenatal Screening and DiagnosticsReproductive Biology and FertilityAssisted Reproductive Technology and Twin Pregnancy

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Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos

Fragouli, E., Alfarawati, S., Spath, K., Wells, D.·2014·Molecular Human Reproduction

DOI 10.1093/molehr/gat073

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Abstract

Morphological assessments are the main way in which fertility clinics select in vitro generated embryo(s) for transfer to the uterus. However, it is widely acknowledged that the microscopic appearance of an embryo is only weakly correlated with its viability. Furthermore, the extent to which morphology is affected by aneuploidy, a genetic defect common in human preimplantation embryos, remains unclear. Aneuploidy is of great relevance to embryo selection as it represents one of the most important causes of implantation failure and miscarriage. The current study aimed to examine whether morphological appearance can assist in identifying embryos at risk of aneuploidy. Additionally, the data produced sheds light on how chromosomal anomalies impact development from the cleavage to the blastocyst stage. A total of 1213 embryos were examined. Comprehensive chromosome analysis was combined with well-established criteria for the assessment of embryo morphology. At the cleavage stage, chromosome abnormalities were common even amongst embryos assigned the best morphological scores, indicating that aneuploidy has little effect on microscopic appearance at fixed time points up until Day 3 of development. However, at the blastocyst stage aneuploidies were found to be significantly less common among embryos of optimal morphological quality, while such abnormalities were overrepresented amongst embryos considered to be of poor morphology. Despite the link between aneuploidy and blastocyst a…

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Additional file 1 of Whole transcriptome analysis to identify non-coding RNA regulators and hub genes in sperm of non-obstructive azoospermia by microarray, single-cell RNA sequencing, weighted gene co-expression network analysis, and mRNA-miRNA-lncRNA interaction analysis
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Additional file 3 of Whole transcriptome analysis to identify non-coding RNA regulators and hub genes in sperm of non-obstructive azoospermia by microarray, single-cell RNA sequencing, weighted gene co-expression network analysis, and mRNA-miRNA-lncRNA interaction analysis
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Additional file 2 of The impact of clinical and laboratory parameters on clinical pregnancy and live birth rates in fresh cycles: a retrospective study of 9608 high-quality cleavage-stage embryos
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Additional file 1 of Competent blastocyst and receptivity endometrium improved clinical pregnancy in fresh embryo transfer cycles: a retrospective cohort study
Wang, L., Qiu, P., Jiang, L., Li, P., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25591313
Additional file 3 of The impact of clinical and laboratory parameters on clinical pregnancy and live birth rates in fresh cycles: a retrospective study of 9608 high-quality cleavage-stage embryos
Zhao, H., Gan, K., Ji, X., Zheng, L., Ou, S., Mei, M., Zhang, Q., Chen, H., Yuan, P., & Wang, W. (2024) · Figshare · doi:10.6084/m9.figshare.26683912
Additional file 4 of The impact of clinical and laboratory parameters on clinical pregnancy and live birth rates in fresh cycles: a retrospective study of 9608 high-quality cleavage-stage embryos
Zhao, H., Gan, K., Ji, X., Zheng, L., Ou, S., Mei, M., Zhang, Q., Chen, H., Yuan, P., & Wang, W. (2024) · Figshare · doi:10.6084/m9.figshare.26683915
Additional file 1 of Clinical outcome of different embryo transfer strategies after late rescue ICSI procedure: a 10-year total fertilisation failure cohort study
Zhu, X., Tian, T., Jiesisibieke, D., Fang, S., Zhang, N., Ma, J., Xia, Y., Liu, P., Li, R., Qiao, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23812410
Additional file 1 of The impact of clinical and laboratory parameters on clinical pregnancy and live birth rates in fresh cycles: a retrospective study of 9608 high-quality cleavage-stage embryos
Zhao, H., Gan, K., Ji, X., Zheng, L., Ou, S., Mei, M., Zhang, Q., Chen, H., Yuan, P., & Wang, W. (2024) · Figshare · doi:10.6084/m9.figshare.25264337
Additional file 2 of Whole transcriptome analysis to identify non-coding RNA regulators and hub genes in sperm of non-obstructive azoospermia by microarray, single-cell RNA sequencing, weighted gene co-expression network analysis, and mRNA-miRNA-lncRNA interaction analysis
Karoii, D. H., Azizi, H., & Skutella, T. (2024) · Figshare · doi:10.6084/m9.figshare.26011986

Authors: Fragouli, E., Alfarawati, S., Spath, K., & Wells, D.
Affiliations: University of Oxford (GB)
Corresponding author: Fragouli, E.
ORCID: Fragouli, E.
Wells, D.
Venue: Molecular Human Reproduction
Publisher: Oxford University Press (OUP)
Published: 2013-11-01
Volume: 20
Issue: 2
Pages: 117-126
ISSN: 1360-9947 (ISSN-L)
1460-2407
DOI: 10.1093/molehr/gat073
OpenAlex: W2142766753
Cited by: 189
References: 44
Citations by year: 2025: 11 · 2024: 22 · 2023: 22 · 2022: 18 · 2021: 24 · 2020: 15 · 2019: 15 · 2018: 13 · 2017: 17 · 2016: 13 · 2015: 11 · 2014: 8
FWCI: 9.93
Type: journal article
Language: en
Open access: closed
Locations: Molecular Human Reproduction (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords: embryo morphology, aneuploidy, preimplantation embryo, cleavage stage, blastocyst, embryo selection, chromosomal abnormalities, Down syndrome, sex ratio, embryo growth rate, implantation failure
MeSH terms: Aneuploidy, Blastocyst, Chromosomes, Human, Embryo Transfer, Female, Fertilization in Vitro, Humans, Male, Microscopy, Embryo Implantation, Pregnancy, Research Design, In Situ Hybridization, Fluorescence, Preimplantation Diagnosis, Cytogenetic Analysis, Comparative Genomic Hybridization

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Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos

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