The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes
Abstract
Micronucleus (MN) frequency in cytokinesis-blocked peripheral blood lymphocytes (PBL) has become one of the best-established biomarkers for studying DNA damage occurring in vivo in humans. The application of this method in population biomonitoring studies requires a deep understanding of how lifestyle and common host variables may influence MN frequency in PBL. In this mini-review, an update is provided on results from studies reporting on the impact of age, gender, diet and lifestyle factors (e.g. exercise, alcohol, smoking and recreational drugs) on this biomarker. Evidence from these studies shows that each of these factors, either in isolation or in combination, can significantly influence MN frequency. Proper control for these factors is required to enable better measurement of the impact of other conditions, such as environmental exposure to genotoxins or a susceptible genetic background, on MN frequency in PBL.
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Cytokinesis-block micronucleus cytome assay
Fenech, M. (2007) · Nature Protocols · doi:10.1038/nprot.2007.77 · Cited by 2,019
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Self-citationMertz, W. (1981) · Science · doi:10.1126/science.7022654 · Cited by 982
Fenech, M., Holland, N., Chang, W. P., Zeiger, E., & Bonassi, S. (1999) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s1383-5742(99)00053-8 · Cited by 605
Self-citationFenech, M., & Morley, A. A. (1986) · Mutation Research · doi:10.1016/0027-5107(86)90010-2 · Cited by 549
Self-citationMicronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies
Bonassi, S., El-Zein, R., Bolognesi, C., & Fenech, M. (2011) · Mutagenesis · doi:10.1093/mutage/geq075 · Cited by 471
Self-citationThe role of folic acid and Vitamin B12 in genomic stability of human cells
Fenech, M. (2001) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(01)00079-3 · Cited by 470
Self-citationQuantifying the effect of folic acid
Wald, N., Law, M., Morris, J., & Wald, D. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07104-5 · Cited by 434
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Metadata
- Authors
- Fenech, M., & Bonassi, S.
- Venue
- Mutagenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12-16
- Volume
- 26
- Issue
- 1
- Pages
- 43-49
- ISSN
- 0267-8357 (ISSN-L)
- 1464-3804
- OpenAlex
- W2132607882
- Cited by
- 371
- References
- 56
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
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