Cited by 45Carcinogens and Genotoxicity AssessmentExercise and Physiological ResponsesGenetics, Aging, and Longevity in Model Organisms

The effect of six months of elastic band resistance training, nutritional supplementation or cognitive training on chromosomal damage in institutionalized elderly

Franzke, Bernhard, Halper, Barbara, Hofmann, Marlene, Oesen, Stefan, Pierson, Béatrice, Cremer, Ariane, Bacher, Evelyn, Fuchs, Birgit +5 more·2015·Experimental Gerontology

Abstract

Increased DNA and chromosomal damage are linked to aging and age-related diseases like cardiovascular diseases, diabetes or cancer. Physical activity and an optimal status of micro- and macronutrients are known to reduce the incidence of MN, a marker for chromosomal instability and mutagenicity. Once older people reach a certain age they change from a home-living situation to an institutionalized situation, which is often accompanied by malnutrition, depression and inactivity. We conducted the current study to investigate the effect of a six month progressive resistance training (RT), with or without protein and vitamin supplementation (RTS) or cognitive training (CT) only, on chromosomal damage measured by the cytokinesis block micronucleus cytome assay in 97 Austrian institutionalized women and men (65-98years). All three intervention groups demonstrated a tendency of a reduced frequency of cells with MN (-15%) as well as for the total number of MN (-20%), however no significant time-effect was observed. Besides a significant increase in plasma B12 and red blood cell folate status, the six month change of B12 was negatively correlated with the six month change of the MN frequency in the RTS group (r=-0.584, p=0.009). Our results suggest that in this age group either physical or cognitive training may result in similar biochemical changes and therefore enhance resistance against genomic instability. Supplementation with the vitamins B12 and folic acid could contribute to reduced chromosomal damage in institutionalized elderly.

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Crossref · 10.1016/j.exger.2015.03.001

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Authors
Franzke, B., Halper, B., Hofmann, M., Oesen, S., Pierson, B., Cremer, A., Bacher, E., Fuchs, B., Baierl, A., Tosevska, A., Strasser, E.-M., Wessner, B., & Wagner, K.-H.
Affiliations
  • University of Vienna (AT)
  • Kaiser-Franz-Josef-Spital (AT)
Corresponding author
Wagner, Karl-Heinz
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2015-05
Volume
65
Pages
16-22
ISSN
0531-5565 (ISSN-L)
OpenAlex
W2069094259
Cited by
45
References
49
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 2
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Vienna (14541)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
chromosomal damage, micronuclei, resistance training, protein supplementation, vitamin supplementation, cognitive training, institutionalized elderly, genomic instability, vitamin B12, folic acid, aging, physical activity
MeSH terms
Aged, Aged, 80 and over, Aging, Cognition, Diet Therapy, Female, Homes for the Aged, Humans, Lymphocytes, Male, Nursing Homes, Nutritive Value, Vitamins, Geriatric Assessment, Dietary Supplements, Chromosomal Instability, Resistance Training, Compression Bandages

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