The effect of six months of elastic band resistance training, nutritional supplementation or cognitive training on chromosomal damage in institutionalized elderly
Abstract
Increased DNA and chromosomal damage are linked to aging and age-related diseases like cardiovascular diseases, diabetes or cancer. Physical activity and an optimal status of micro- and macronutrients are known to reduce the incidence of MN, a marker for chromosomal instability and mutagenicity. Once older people reach a certain age they change from a home-living situation to an institutionalized situation, which is often accompanied by malnutrition, depression and inactivity. We conducted the current study to investigate the effect of a six month progressive resistance training (RT), with or without protein and vitamin supplementation (RTS) or cognitive training (CT) only, on chromosomal damage measured by the cytokinesis block micronucleus cytome assay in 97 Austrian institutionalized women and men (65-98years). All three intervention groups demonstrated a tendency of a reduced frequency of cells with MN (-15%) as well as for the total number of MN (-20%), however no significant time-effect was observed. Besides a significant increase in plasma B12 and red blood cell folate status, the six month change of B12 was negatively correlated with the six month change of the MN frequency in the RTS group (r=-0.584, p=0.009). Our results suggest that in this age group either physical or cognitive training may result in similar biochemical changes and therefore enhance resistance against genomic instability. Supplementation with the vitamins B12 and folic acid could contribute to reduced chromosomal damage in institutionalized elderly.
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Participants with higher attendance or motivation at the training sessions have better performance in mobility.
“participants with higher attendance or motivation at the training sessions have better performance in mobility [50,56]”
From Effects of Protein Supplementation Combined with Exercise Intervention on Frailty Indices, Body Composition, and Physical Function in Frail Older Adults (2018) · cites this paper as [50]
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- Authors
- Franzke, B., Halper, B., Hofmann, M., Oesen, S., Pierson, B., Cremer, A., Bacher, E., Fuchs, B., Baierl, A., Tosevska, A., Strasser, E.-M., Wessner, B., & Wagner, K.-H.
- Affiliations
- University of Vienna (AT)
- Kaiser-Franz-Josef-Spital (AT)
- Corresponding author
- Wagner, Karl-Heinz
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 65
- Pages
- 16-22
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2069094259
- Cited by
- 45
- References
- 49
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Vienna (14541)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- chromosomal damage, micronuclei, resistance training, protein supplementation, vitamin supplementation, cognitive training, institutionalized elderly, genomic instability, vitamin B12, folic acid, aging, physical activity
- MeSH terms
- Aged, Aged, 80 and over, Aging, Cognition, Diet Therapy, Female, Homes for the Aged, Humans, Lymphocytes, Male, Nursing Homes, Nutritive Value, Vitamins, Geriatric Assessment, Dietary Supplements, Chromosomal Instability, Resistance Training, Compression Bandages
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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