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Base-base mismatches. Thermodynamics of double helix formation for dCA3XA3G + dCT3YT3G (X, Y = A,C,G,D
Open accessAbstract
Thermodynamic parameters for double strand formation have been measured for the sixteen double helices of the sequence dCA3XA3G.dCT3YT3G, with each of the bases A, C, G and T at the positions labelled X and Y. The results are analyzed in terms of nearest-neighbors and are compared with thermodynamic parameters for RNA secondary structure. At room temperature the sequence (Formula: see text) is more stable than (Formula: see text) and is similar in stability to (Formula: see text) and (Formula: see text) are least stable. At higher temperatures the sequences containing a G.C base pair become more stable than those containing only A.T. All molecules containing mismatches are destabilized with respect to those with only Watson-Crick pairing, but there is a wide range of destabilization. At room temperature the most stable mismatches are those containing guanine (G.T, G.G, G.A); the least stable contain cytosine (C.A, C.C). At higher temperatures pyrimidine-pyrimidine mismatches become the least stable.
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Citations
Cited by
Predicting DNA duplex stability from the base sequence
Breslauer, K. J., Frank, R., Blöcker, H., & Marky, L. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3746 · Cited by 1,837
Xia, T., SantaLucia, J., Burkard, M. E., Kierzek, R., Schroeder, S. J., Jiao, X., Cox, C., & Turner, D. H. (1998) · Biochemistry · doi:10.1021/bi9809425 · Cited by 1,140
Thermodynamic basis of the enhanced specificity of structured DNA probes
Bonnet, G., Tyagi, S., Libchaber, A., & Kramer, F. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6171 · Cited by 658
Biochemical Basis of DNA Replication Fidelity
Goodman, M. F., Creighton, S., Bloom, L. B., Petruska, J., & Kunkel, T. A. (1993) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239309086792 · Cited by 446
DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.
Boosalis, M. S., Petruska, J., & Goodman, M. F. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47850-7 · Cited by 332
Metadata
- Authors
- Aboul-ela, F., Koh, D., Tinoco, I., & Martin, F. H.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1985
- Volume
- 13
- Issue
- 13
- Pages
- 4811-4824
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2042932259
- Cited by
- 428
- References
- 0
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Base-base mismatches. Thermodynamics of double helix formation for dCA3XA3G + dCT3YT3G (X, Y = A,C,G,D. https://app.cochat.ai/papers/10.1093/nar/13.13.4811
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- Aboul-ela, F., Koh, D., Tinoco, I., & Martin, F. H. (1985). Base-base mismatches. Thermodynamics of double helix formation for dCA3XA3G + dCT3YT3G (X, Y = A,C,G,D. Nucleic Acids Research. https://doi.org/10.1093/nar/13.13.4811
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