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Human rhinovirus 2: complete nucleotide sequence and proteolytic processing signals in the capsid protein region

Open access
Skern, Tim, Sommergruber, Wolfgang, Blaas, Dieter, Gruendler, Peter, Fraundorfer, Franz, Pieler, Christian, Fogy, Ingrid, Kuechler, Ernst·1985·Nucleic Acids Research

Abstract

cDNA clones representing the entire genome of human rhinovirus 2 have been obtained and used to determine the complete nucleotide sequence. The genome consists of 7102 nucleotides and possesses a long open reading frame of 6450 nucleotides; this reading frame is initiated 611 nucleotides from the 5' end and stops 42 nucleotides from the polyA tract. The N-terminal sequences of three of the viral capsid proteins have been elucidated, thus defining the positions of three cleavage sites on the polyprotein. The extensive amino acid sequence homology with poliovirus and human rhinovirus 14 enabled the other cleavage sites to be predicted. Cleavages in the 3' half of the molecule appear to take place predominantly at Gln-Gly pairs, whereas those in the 5' half (including the capsid proteins) are more heterogeneous.

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Metadata

Authors
Skern, T., Sommergruber, W., Blaas, D., Gruendler, P., Fraundorfer, F., Pieler, C., Fogy, I., & Kuechler, E.
Venue
Nucleic Acids Research
Published
1985
Volume
13
Issue
6
Pages
2111-2126
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2026066831
Cited by
183
References
0
FWCI
14.80
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Human rhinovirus 2: complete nucleotide sequence and proteolytic processing signals in the capsid protein region. https://app.cochat.ai/papers/10.1093/nar/13.6.2111
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Skern, T., Sommergruber, W., Blaas, D., Gruendler, P., Fraundorfer, F., Pieler, C., Fogy, I., & Kuechler, E. (1985). Human rhinovirus 2: complete nucleotide sequence and proteolytic processing signals in the capsid protein region. Nucleic Acids Research. https://doi.org/10.1093/nar/13.6.2111

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