New treatment regimes for virus-induced exacerbations of asthma
Open accessAbstract
This review will focus on the role of viruses as causes of asthma exacerbations. The article will briefly review the current literature supporting this view, with a special focus on human rhinovirus (RV), the main virus associated with exacerbations of asthma. The review will then refer to possible strategies for treatment, and will include discussion on treatment with specific anti-viral therapy and type I interferon as a treatment for RV. The review will also include a discussion on current therapies for asthma, such as glucocorticosteroid and beta(2) agonist therapy alone and in combination and why this may be relevant to virus-induced exacerbations of asthma. Finally, the potential for future anti-inflammatory/immunomodulatory therapies with a focus on NF-kappaB inhibition will be discussed.
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Early studies demonstrated increased susceptibility of mammalian cells to bacterial adherence as a result of viral infection in vitro and in vivo.
“Early studies demonstrated increased susceptibility of mammalian cells to bacterial adherence as a result of viral infection in vitro (60, 251) and in vivo (131, 204, 213, 215, 250).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [60]
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The airway epithelium: soldier in the fight against respiratory viruses
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Self-citation
- Authors
- Edwards, M. R., Kebadze, T., Johnson, M. W., & Johnston, S. L.
- Affiliations
- Imperial College London (GB)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Edwards, Michael R.
- Venue
- Pulmonary Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 19
- Issue
- 5
- Pages
- 320-334
- ISSN
- 1094-5539 (ISSN-L)
- PMC
- PMC7172610
- OpenAlex
- W2009098577
- Cited by
- 30
- References
- 175
- Citations by year
- 2023: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pulmonary Pharmacology & Therapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- asthma exacerbations, respiratory viral infections, human rhinovirus, antiviral therapy, type I interferon, glucocorticoids, beta2-adrenergic agonists, combination therapy, anti-inflammatory therapy, immunomodulatory therapy, NF-κB inhibition
- MeSH terms
- Adrenergic beta-Agonists, Anti-Inflammatory Agents, Antiviral Agents, Asthma, Glucocorticoids, Humans, Immunologic Factors, Interferon Type I, Respiratory Syncytial Viruses, Rhinovirus
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