Cited by 30Asthma and respiratory diseasesRespiratory viral infections researchChronic Obstructive Pulmonary Disease (COPD) Research

New treatment regimes for virus-induced exacerbations of asthma

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Edwards, Michael R., Kebadze, Tatiana, Johnson, Malcolm W., Johnston, Sebastian L.·2006·Pulmonary Pharmacology & Therapeutics

Abstract

This review will focus on the role of viruses as causes of asthma exacerbations. The article will briefly review the current literature supporting this view, with a special focus on human rhinovirus (RV), the main virus associated with exacerbations of asthma. The review will then refer to possible strategies for treatment, and will include discussion on treatment with specific anti-viral therapy and type I interferon as a treatment for RV. The review will also include a discussion on current therapies for asthma, such as glucocorticosteroid and beta(2) agonist therapy alone and in combination and why this may be relevant to virus-induced exacerbations of asthma. Finally, the potential for future anti-inflammatory/immunomodulatory therapies with a focus on NF-kappaB inhibition will be discussed.

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Crossref · 10.1016/j.pupt.2005.09.005

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  • Early studies demonstrated increased susceptibility of mammalian cells to bacterial adherence as a result of viral infection in vitro and in vivo.

    “Early studies demonstrated increased susceptibility of mammalian cells to bacterial adherence as a result of viral infection in vitro (60, 251) and in vivo (131, 204, 213, 215, 250).”

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Authors
Edwards, M. R., Kebadze, T., Johnson, M. W., & Johnston, S. L.
Affiliations
  • Imperial College London (GB)
  • GlaxoSmithKline (United Kingdom) (GB)
Corresponding author
Edwards, Michael R.
Venue
Pulmonary Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2006-10
Volume
19
Issue
5
Pages
320-334
ISSN
1094-5539 (ISSN-L)
OpenAlex
W2009098577
Cited by
30
References
175
Citations by year
2023: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 1
FWCI
0.21
Type
journal article
Language
en
Open access
Locations
  • Pulmonary Pharmacology & Therapeutics (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
asthma exacerbations, respiratory viral infections, human rhinovirus, antiviral therapy, type I interferon, glucocorticoids, beta2-adrenergic agonists, combination therapy, anti-inflammatory therapy, immunomodulatory therapy, NF-κB inhibition
MeSH terms
Adrenergic beta-Agonists, Anti-Inflammatory Agents, Antiviral Agents, Asthma, Glucocorticoids, Humans, Immunologic Factors, Interferon Type I, Respiratory Syncytial Viruses, Rhinovirus

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