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Diversity in G+C content at the third position of codons in vertebrate genes and its cause
Open accessAbstract
Correlation was positive between the G + C content at the codon third position in genes of vertebrates and the G + C content of the genome portion surrounding each gene. Exons of genes with a high G + C% at the codon 3rd position are surrounded by G + C-rich introns and G + C-rich flanking sequences, and those with a low G + C% at the position by A + T-rich introns and flanking sequences. Analysis of G + C content distribution along DNA sequences using a DNA Sequence Data Bank supported the view that the vertebrate genome is a mosaic of regions with clear differences in their G + C content. The biological significance of the variation in G + C content throughout the vertebrate genome is discussed in connection with chromosomal banding.
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Citations
Cited by
The ‘effective number of codons’ used in a gene
Wright, F. (1990) · Gene · doi:10.1016/0378-1119(90)90491-9 · Cited by 2,309
Synonymous codon usage in Drosophila melanogaster: Natural selection and translational accuracy
Akashi, H. (1994) · Genetics · doi:10.1093/genetics/136.3.927 · Cited by 742
Codon usage tabulated from the GenBank Genetic Sequence Data
Aota, S.-I., Gojobori, T., Ishibashi, F., Maruyama, T., & Ikemura, T. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.suppl.r315 · Cited by 600
Self-citationSharp, P. M., Cowe, E., Higgins, D. G., Shields, D. C., Wolfe, K. H., & Wright, F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.17.8207 · Cited by 594
High Guanine and Cytosine Content Increases mRNA Levels in Mammalian Cells
Kudla, G., Lipinski, L., Caffin, F., Helwak, A., & Zylicz, M. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040180 · Cited by 476
Metadata
- Authors
- Aota, S.-I., & Ikemura, T.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 14
- Issue
- 16
- Pages
- 6345-6355
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2033145713
- Cited by
- 199
- References
- 0
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Aota, S.-I., & Ikemura, T. (1986). Diversity in G+C content at the third position of codons in vertebrate genes and its cause. Nucleic Acids Research. https://doi.org/10.1093/nar/14.16.6345
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