The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Compilation and analysis of eukaryotic POL II promoter sequences
Open accessAbstract
A representative set of 168 eukaryotic POL II promoters has been compiled from the EMBL library and subjected to computer signal search analysis. Application of this technique to E. coli promoters as a control ensemble revealed the well known consensus sequences at -35 and -10 which indicates that the methods are adequate to approach problems of this kind. The results obtained from the eukaryotic promoter set can be summarized as follows: Common sequence features are confined to a region between -50 and +10 relative to the transcriptional initiation site. The only well conserved consensus sequence is TATAAA, centered at -28. A weak motif, CA followed preferentially by pyrimidines, surrounds the cap-site. Two pentanucleotides which have been shown by experiments to stimulate transcription of certain genes, GGGCG and CCAAT, are moderately over-represented in the upstream region (between -129 and -50). However, they occur at highly variable distances from the initiation site.
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Cites
Dynan, W. S., & Tjian, R. (1983) · Cell · doi:10.1016/0092-8674(83)90210-6 · Cited by 1,445
In vivo sequence requirements of the SV40 early promoter region
Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074
Cited by
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
Heinemeyer, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.362 · Cited by 1,451
The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR
Fiorese, C. J., Schulz, A. M., Lin, Y.-F., Rosin, N., Pellegrino, M. W., & Haynes, C. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.002 · Cited by 667
YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro
Seto, E., Shi, Y., & Shenk, T. (1991) · Nature · doi:10.1038/354241a0 · Cited by 447
Cameron, G. N. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.5.1865 · Cited by 316
Wobbe, C. R., & Struhl, K. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.8.3859 · Cited by 283
Metadata
- Authors
- Bucher, P., & Trifonov, E. N.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 14
- Issue
- 24
- Pages
- 10009-10026
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2016923471
- Cited by
- 331
- References
- 2
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bucher, P., & Trifonov, E. N. (1986). Compilation and analysis of eukaryotic POL II promoter sequences. Nucleic Acids Research. https://doi.org/10.1093/nar/14.24.10009
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