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Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields
Open accessAbstract
Excellent resolution of chromosomal DNA molecules from Saccharomyces cerevisiae, Candida albicans and Schizosaccharomyces pombe has been obtained using alternating contour-clamped homogeneous electric field (CHEF) gel electrophoresis. The largest of these molecules is greater than 5 Mb in size and is resolved after 130 hours in a 0.6% agarose gel at a field strength of 1.3 V/cm and a switching interval of 1 hour. Separation of concatamers of phage lambda DNA reveals four regions of resolution in alternating CHEF gel electrophoresis. There are two regions of good resolution in which mobility approximates a linear function of molecular weight. These are separated by a region of lower resolution and bounded at high molecular weights by a region of little or no resolution. The four regions are of practical and possibly theoretical importance.
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Cited by
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Metadata
- Authors
- Vollrath, D., & Davis, R. W.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 15
- Issue
- 19
- Pages
- 7865-7876
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2114633278
- Cited by
- 297
- References
- 0
- FWCI
- 45.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Vollrath, D., & Davis, R. W. (1987). Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields. Nucleic Acids Research. https://doi.org/10.1093/nar/15.19.7865
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