Cited by 115DNA Repair MechanismsFungal and yeast genetics researchNuclear Structure and Function

Differential repair of UV damage in Saccharomyces cerevisiae

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Terleth, C, van Sluis, C.A., van de Putte, P.·1989·Nucleic Acids Research

Abstract

Preferential repair of UV-induced damage is a phenomenon by which mammalian cells might enhance their survival. This paper presents the first evidence that preferential repair occurs in the lower eukaryote Saccharomyces cerevisiae. Moreover an unique approach is reported to compare identical sequences present on the same chromosome and only differing in expression. We determined the removal of pyrimidine dimers from two identical alpha-mating type loci and we were able to show that the active MAT alpha locus is repaired preferentially to the inactive HML alpha locus. In a sir-3 mutant, in which both loci are active this preference is not observed.

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Crossref · 10.1093/nar/17.12.4433

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Authors
Terleth, C., van Sluis, C. A., & van de Putte, P.
Affiliations
Leiden University (NL)
Venue
Nucleic Acids Research
Published
1989
Volume
17
Issue
12
Pages
4433-4439
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2090418393
Cited by
115
References
26
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
FWCI
4.51
Type
journal article
Language
en
Open access
Locations
  • Nucleic Acids Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
UV-induced DNA damage, pyrimidine dimers, DNA repair, Saccharomyces cerevisiae, mating-type locus, gene expression
MeSH terms
DNA Damage, DNA Repair, DNA, Fungal, Dose-Response Relationship, Radiation, Genes, Fungal, Mutation, Pyrimidine Dimers, Saccharomyces cerevisiae, Transcription, Genetic, Ultraviolet Rays, Deoxyribonucleases, Type II Site-Specific

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