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Rapid segregation of heteroplasmic bovine mitodiondria
Open accessAbstract
By following the transmission of a heteroplasmic mitochondrial DNA mutation through four generations of Holstein cows, we have documented that substantial shifts in the levels of heteroplasmy can occur between single mammalian generations, that neutral mitochondrial genotypes can segregate in different directions in offspring of the same female, and that a return to homoplasmy may occur in only two or three generations. This apparently rapid rate of mitochondrial DNA segregation in mammals contrasts to the much slower rates observed previously in insects and suggest fundamental differences between taxa regarding the mechanisms of mitochondrial gene transmission.
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Citations
Cited by
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666
Transcriptional integration of mitochondrial biogenesis
Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.006 · Cited by 798
Jenuth, J. P., Peterson, A. C., Fu, K., & Shoubridge, E. A. (1996) · Nature Genetics · doi:10.1038/ng1096-146 · Cited by 591
Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice
Jenuth, J. P., Peterson, A. C., & Shoubridge, E. A. (1997) · Nature Genetics · doi:10.1038/ng0597-93 · Cited by 415
The Units of Selection on Mitochondrial DNA
Rand, D. M. (2001) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.ecolsys.32.081501.114109 · Cited by 359
Metadata
- Authors
- Ashley, M. V., Laipis, P. J., & Hauswirth, W. W.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 17
- Issue
- 18
- Pages
- 7325-7331
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2028174481
- Cited by
- 232
- References
- 0
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ashley, M. V., Laipis, P. J., & Hauswirth, W. W. (1989). Rapid segregation of heteroplasmic bovine mitodiondria. Nucleic Acids Research. https://doi.org/10.1093/nar/17.18.7325
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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