Transcriptional integration of mitochondrial biogenesis

Immunity, Inflammation, and Cancer

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Brown Adipose Tissue: Function and Physiological Significance

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Why Do Cancers Have High Aerobic Glycolysis?

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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tRNA punctuation model of RNA processing in human mitochondria

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

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NF-κB, Inflammation, and Metabolic Disease

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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Mitochondrial Evolution

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Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works

The mitochondrial genome: structure, transcription, translation and replication

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Towards a molecular understanding of adaptive thermogenesis

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Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice

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Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

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mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

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Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide

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Regulation of pgc-1α, a nodal regulator of mitochondrial biogenesis

Fernandez-Marcos, P. J., & Auwerx, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.001917 · Cited by 1,237 · see citing works

The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1868-1876.2000 · Cited by 1,195 · see citing works

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works

Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism

Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works

Primary response genes induced by growth factors and tumor promoters.

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Fmr1 knockout mice: A model to study fragile X mental retardation

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MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES

Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,059 · see citing works

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal · doi:10.1096/fj.02-0367com · Cited by 1,020 · see citing works

Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1

Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971 · see citing works

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

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Human mitochondrial DNA deletions associated with mutations in the gene encoding twinkle, a phage T7 gene 4-like protein localized in mitochondria

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Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

Nagase, T. (1998) · DNA Research · doi:10.1093/dnares/5.1.31 · Cited by 845 · see citing works

Activation of the human mitochondrial transcriptionfactor A gene by nuclear respiratory factors: a potential regulatory linkbetween nuclear and mitochondrial gene expression in organellebiogenesis.

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SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.023 · Cited by 785 · see citing works

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.014 · Cited by 782 · see citing works

Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

Puigserver, P., Rhee, J., Lin, J., Wu, Z., Yoon, J. C., Zhang, C.-Y., Krauss, S., Mootha, V. K., Lowell, B. B., & Spiegelman, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00390-2 · Cited by 732 · see citing works

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718 · see citing works

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

Gleyzer, N., Vercauteren, K., & Scarpulla, R. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1354-1366.2005 · Cited by 711 · see citing works

Paternal Inheritance of Mitochondrial DNA

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Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

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ERRα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

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The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

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Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

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Senescent cells as a source of inflammatory factors for tumor progression

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Nuclear activators and coactivators in mammalian mitochondrial biogenesis

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Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

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Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

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Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

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The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.

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A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

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Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor

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Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins

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Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells

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Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes.

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CROSSTALK BETWEEN NUCLEAR AND MITOCHONDRIAL GENOMES

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Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals

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EUKARYOTIC DNA POLYMERASES

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Peroxisome Proliferator-activated Receptor Coactivator-1α (PGC-1α) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-α and -γ

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Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis.

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Inflammation and oncogenesis: a vicious connection

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Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

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The Transcriptional Coactivator PGC-1 Regulates the Expression and Activity of the Orphan Nuclear Receptor Estrogen-Related Receptor α (ERRα)

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Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex

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Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos

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Regulation of oxidative phosphorylation in the mammalian cell

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Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer.Preprint

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Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA

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Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ

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Regulation of gene expression by oxygen in Saccharomyces cerevisiae

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Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell

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Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.

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Inflammation and Alzheimer’s disease

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Direct Coupling of Transcription and mRNA Processing through the Thermogenic Coactivator PGC-1

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Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

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Targeted Disruption of Mouse Yin Yang 1 Transcription Factor Results in Peri-Implantation Lethality

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The Orphan Nuclear Receptor Estrogen-Related Receptor α Is a Transcriptional Regulator of the Human Medium-Chain Acyl Coenzyme A Dehydrogenase Gene

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PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells

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Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells.

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